Two new isoquinoline alkaloids from Hypecoum leptocarpum Hook. f. et Thoms

Two new isoquinoline alkaloids, hypecocarpinine (1) and leptocaramine (2) along with five known ones including leptopidine (3), corydamine (4), protopine (5), dihydroprotopine (6) and oxohydrastinine (7), were isolated from Hypecoum leptocarpum Hook. f. et Thoms. Structures of the compounds were elucidated using spectroscopic methods, including UV, IR, HR-ESI-MS, 1 D and 2 D NMR. The cytotoxic activities of these compounds were evaluated using MTT assay. The results showed that compounds 2, 4, and 7 have moderate cytotoxicity against human lung cancer (A549) and human gastric carcinoma (MGC-803) cell lines.

Automated summary

Two new isoquinoline alkaloids, along with five known compounds, were isolated from Hypecoum leptocarpum. The structures of these compounds were determined using spectroscopic techniques, and their cytotoxic activities were evaluated. Some of the compounds showed moderate cytotoxicity against lung cancer and gastric carcinoma cell lines.