☆ 4.8 Review

Active therapy based on the byproducts of micro/nanomotors

NANOSCALE (2023)

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Review Pharmacology & Pharmacy

Medical micro- and nanomotors in the body

Huaan Li et al.

Summary: Attributed to their miniaturized body size and active mobility, micro-and nanomotors (MNMs) have displayed significant potential for medical applications. However, addressing critical issues such as cost-effective fabrication, integration of multiple functions, biocompatibility, biodegradability, controlled propulsion, and in vivo navigation requires substantial efforts. In this review, we summarize the advancements of biomedical MNMs over the past two decades, focusing on design, fabrication, propulsion, navigation, as well as their abilities for barrier penetration, biosensing, diagnosis, minimally invasive surgery, and targeted cargo delivery. Future perspectives and challenges are also discussed. This review lays the foundation for the future development of medical MNMs, taking a step forward towards practical theranostics using MNMs.

ACTA PHARMACEUTICA SINICA B (2023)

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Article Chemistry, Multidisciplinary

Magnetic Nanorobots as Maneuverable Immunoassay Probes for Automated and Efficient Enzyme Linked Immunosorbent Assay

Yong Wang et al.

Summary: This study introduces a novel approach using MNRs as maneuverable immunoassay probes to achieve automated and efficient ELISA analysis, significantly reducing assay time and minimizing manpower input.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Nanosized Janus AuNR-Pt Motor for Enhancing NIR-II Photoacoustic Imaging of Deep Tumor and Pt2+ Ion-Based Chemotherapy

Qingqing Li et al.

Summary: A nanosized hydrogen peroxide-driven Janus gold nanorod-platinum nanomotor was developed for deep tissue imaging and tumor treatment, showing enhanced cellular uptake and effective antitumor effects.

ACS NANO (2022)

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Review Chemistry, Multidisciplinary

Functional gold nanoparticles for diagnosis, treatment and prevention of thrombus

Jiatong Lv et al.

Summary: This review highlights the multifunctional roles of gold nanoparticles (AuNPs) in thrombus therapy, including visual diagnosis, thrombolytic therapy, and prevention of thrombosis and re-embolism. The superior optical properties, surface plasmon resonance, and biocompatibility of AuNPs make them effective in all stages of thrombus treatment. The application prospects of AuNPs and optimization strategies of their nanocomposites are also discussed.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Chemistry, Multidisciplinary

Bubble-Propelled Janus Gallium/Zinc Micromotors for the Active Treatment of Bacterial Infections

Zhihua Lin et al.

Summary: This study presents a bubble-propelled Janus gallium/zinc (Ga/Zn) micromotor with good biocompatibility and biodegradability, which can actively target bacteria for treatment. The micromotors exhibit self-propulsion in simulated gastroenteric acid and enhanced antibacterial efficiency against H. pylori compared to passive Ga microparticles. The Ga/Zn micromotors combine self-propulsion, biocompatibility, biodegradability, and Ga-based antibacterial properties, showing promise for active treatment of bacterial infections.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Chemistry, Multidisciplinary

Magnesium-Based Micromotors as Hydrogen Generators for Precise Rheumatoid Arthritis Therapy

Cong Xu et al.

Summary: Hydrogen therapy is a promising strategy for inflammation-related diseases, but its efficacy is limited due to nonpolarity and low solubility. A biocompatible magnesium micromotor coated with hyaluronic acid was developed as a hydrogen generator, showing great potential for rheumatoid arthritis therapy by producing hydrogen bubbles for motion and scavenging reactive oxygen species and inflammation. Through ultrasound-guided intra-articular injection, the micromotors effectively relieved oxidative stress, reduced inflammation cytokines, and ameliorated joint damage, showing prominent therapeutic efficacy.

NANO LETTERS (2021)

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Article Chemistry, Multidisciplinary

Nitric Oxide Nanomotor Driving Exosomes-Loaded Microneedles for Achilles Tendinopathy Healing

Anlong Liu et al.

Summary: The detachable microneedle array designed in this study effectively delivered exosomes modified by a nitric oxide nanomotor to the injury site, enhancing the accumulation of exosomes and demonstrating significant potential in treating Achilles tendinopathy.

ACS NANO (2021)

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Review Engineering, Biomedical

Fundamentals and applications of enzyme powered micro/nano-motors

Hao Yuan et al.

Summary: Micro/nanomotors (MNMs) are miniaturized machines capable of converting various forms of energy into mechanical motion. Enzyme-powered micro/nanomotors (EMNMs) utilize enzymes as biocatalysts to provide driving force, offering great biocompatibility in biomedical applications. EMNMs can be endowed with multiple functionalities to accomplish tasks on demand.

BIOACTIVE MATERIALS (2021)

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Review Chemistry, Multidisciplinary

Advanced nitric oxide donors: chemical structure of NO drugs, NO nanomedicines and biomedical applications

Yueqi Yang et al.

Summary: Nitric oxide (NO) plays a key regulatory role in many physiological and pathological processes, and NO gas therapy has attracted increasing attention as a promising treatment method. Despite efforts to develop various NO donors, controlling the long-term release of NO remains challenging. Through support from nanomaterials, spatial and temporal controlled release of NO can be achieved.

NANOSCALE (2021)

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Review Oncology

Clinical development and potential of photothermal and photodynamic therapies for cancer

Xingshu Li et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Review Chemistry, Multidisciplinary

Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer

Yijing Liu et al.

CHEMICAL SOCIETY REVIEWS (2019)

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Article Chemistry, Multidisciplinary

Biomimetic Micromotor Enables Active Delivery of Antigens for Oral Vaccination

Xiaoli Wei et al.

NANO LETTERS (2019)

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Article Chemistry, Multidisciplinary

Real-Time Optoacoustic Tracking of Single Moving Micro-objects in Deep Phantom and Ex Vivo Tissues

Azaam Aziz et al.

NANO LETTERS (2019)

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Article Chemistry, Multidisciplinary

Targeting 3D Bladder Cancer Spheroids with Urease-Powered Nanomotors

Ana C. Hortelao et al.

ACS NANO (2019)

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Article Multidisciplinary Sciences

Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides

Rachel H. Clare et al.

NATURE COMMUNICATIONS (2019)

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Review Medicine, Research & Experimental

Metabolic pathways of L-arginine and therapeutic consequences in tumors

Jaroslaw Szefel et al.

ADVANCES IN MEDICAL SCIENCES (2019)

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Review Chemistry, Multidisciplinary

Fuel-free light-driven micro/nanomachines: artificial active matter mimicking nature

Katherine Villa et al.

CHEMICAL SOCIETY REVIEWS (2019)

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Article Chemistry, Multidisciplinary

Erythrocyte Membrane Modified Janus Polymeric Motors for Thrombus Therapy

Jingxin Shao et al.

ACS NANO (2018)

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Article Chemistry, Multidisciplinary

Noncontinuous Super-Diffusive Dynamics of a Light-Activated Nanobottle Motor

Mingjun Xuan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

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Review Multidisciplinary Sciences

Ureases: Historical aspects, catalytic, and non-catalytic properties - A review

Karine Kappaun et al.

JOURNAL OF ADVANCED RESEARCH (2018)

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Article Chemistry, Multidisciplinary

Micromotor Pills as a Dynamic Oral Delivery Platform

Emil Karshalev et al.

ACS NANO (2018)

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Article Chemistry, Multidisciplinary

Enzyme-Powered Nanobots Enhance Anticancer Drug Delivery

Ana C. Hortelao et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

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Article Chemistry, Multidisciplinary

Glucose-Responsive Sequential Generation of Hydrogen Peroxide and Nitric Oxide for Synergistic Cancer Starving-Like/Gas Therapy

Wenpei Fan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

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Article Multidisciplinary Sciences

Rotiferan Hox genes give new insights into the evolution of metazoan bodyplans

Andreas C. Froebius et al.

NATURE COMMUNICATIONS (2017)

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Article Robotics

Multifunctional biohybrid magnetite microrobots for imaging-guided therapy

Xiaohui Yan et al.

SCIENCE ROBOTICS (2017)

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Review Chemistry, Multidisciplinary

Light-driven micro/nanomotors: from fundamentals to applications

Leilei Xu et al.

CHEMICAL SOCIETY REVIEWS (2017)

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Review Chemistry, Multidisciplinary

Micro/nanomotors towards in vivo application: cell, tissue and biofluid

Fei Peng et al.

CHEMICAL SOCIETY REVIEWS (2017)

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Article Chemistry, Multidisciplinary

Highly Efficient Light-Driven TiO2-Au Janus Micromotors

Renfeng Dong et al.

ACS NANO (2016)

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Article Chemistry, Multidisciplinary

Medibots: Dual-Action Biogenic Microdaggers for Single-Cell Surgery and Drug Release

Sarvesh Kumar Srivastava et al.

ADVANCED MATERIALS (2016)

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Article Chemistry, Multidisciplinary

Superfast Near-Infrared Light-Driven Polymer Multilayer Rockets

Zhiguang Wu et al.

SMALL (2016)

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Article Chemistry, Multidisciplinary

Ultrasound-Triggered Nitric Oxide Release Platform Based on Energy Transformation for Targeted Inhibition of Pancreatic Tumor

Kun Zhang et al.

ACS NANO (2016)

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Article Biophysics

Self-propelled affinity biosensors: Moving the receptor around the sample

J. Wang

BIOSENSORS & BIOELECTRONICS (2016)

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Article Chemistry, Multidisciplinary

Near Infrared Light-Powered Janus Mesoporous Silica Nanoparticle Motors

Mingjun Xuan et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

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Review Computer Science, Interdisciplinary Applications

Implantable neurotechnologies: electrical stimulation and applications

Sudip Nag et al.

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING (2016)

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Article Chemistry, Physical

Near-infrared light-driven Janus capsule motors: Fabrication, propulsion, and simulation

Yingjie Wu et al.

NANO RESEARCH (2016)

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Article Chemistry, Physical

Relief from vascular occlusion using photothermal ablation of thrombus with a multimodal perspective

Nitesh Singh et al.

NANO RESEARCH (2016)

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News Item Chemistry, Multidisciplinary

2016 NOBEL PRIZE IN CHEMISTRY Molecular machines

Victoria Richards

NATURE CHEMISTRY (2016)

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Article Chemistry, Multidisciplinary

Single Cell Real-Time miRNAs Sensing Based on Nanomotors

Berta Esteban-Fernandez de Avila et al.

ACS NANO (2015)

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Review Chemistry, Multidisciplinary

Fabrication of Micro/Nanoscale Motors

Hong Wang et al.

CHEMICAL REVIEWS (2015)

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Article Chemistry, Multidisciplinary

Chemically Powered Micro- and Nanomotors

Samuel Sanchez et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

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Review Engineering, Biomedical

Recent advances on the development of magnesium alloys for biodegradable implants

Yongjun Chen et al.

ACTA BIOMATERIALIA (2014)

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Review Chemistry, Multidisciplinary

Nonredox Nickel Enzymes

Michael J. Maroney et al.

CHEMICAL REVIEWS (2014)

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Review Chemistry, Multidisciplinary

Nano/Micromotors in (Bio)chemical Science Applications

Maria Guix et al.

CHEMICAL REVIEWS (2014)

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Article Chemistry, Multidisciplinary

Biopsy with Thermally-Responsive Untethered Microtools

Evin Gultepe et al.

ADVANCED MATERIALS (2013)

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Article Engineering, Biomedical

Toward in vivo detection of hydrogen peroxide with ultrasound molecular imaging

Emilia S. Olson et al.

BIOMATERIALS (2013)

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Article Chemistry, Multidisciplinary

Rolled-up magnetic microdrillers: towards remotely controlled minimally invasive surgery

Wang Xi et al.

NANOSCALE (2013)

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Article Chemistry, Multidisciplinary

Water-Driven Micromotors

Wei Gao et al.

ACS NANO (2012)

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Article Chemistry, Analytical

Quantitative analysis of urea in human urine and serum by H-1 nuclear magnetic resonance

Lingyan Liu et al.

ANALYST (2012)

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Article Chemistry, Multidisciplinary

Hydrogen-Bubble-Propelled Zinc-Based Microrockets in Strongly Acidic Media

Wei Gao et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

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Article Multidisciplinary Sciences

Motion-based DNA detection using catalytic nanomotors

Jie Wu et al.

NATURE COMMUNICATIONS (2010)

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Editorial Material Oncology

Fantastic voyage

Enrique Garcia Jorda

CLINICAL & TRANSLATIONAL ONCOLOGY (2009)

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Review Oncology

Drug resistance and the solid tumor microenvironment

Olivier Tredan et al.

JOURNAL OF THE NATIONAL CANCER INSTITUTE (2007)

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Article Biochemistry & Molecular Biology

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

Ikuroh Ohsawa et al.

NATURE MEDICINE (2007)

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Article Pharmacology & Pharmacy

Nitric oxide and the endothelium: History and impact on cardiovascular disease

Gunay Yetik-Anacak et al.

VASCULAR PHARMACOLOGY (2006)

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Article Chemistry, Multidisciplinary

Catalytic nanomotors: Autonomous movement of striped nanorods

WF Paxton et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)

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Review Chemistry, Multidisciplinary

Nitric oxide donors: Chemical activities and biological applications

PG Wang et al.

CHEMICAL REVIEWS (2002)

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