期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 48, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.nano.2022.102643
关键词
Ultrasound; Chemoradiotherapy; Smart drug delivery system; Methotrexate; Perfluorohexane nanodroplets
This study synthesized folic acid-functionalized methotrexate-loaded nanodroplets and found their potential in ultrasound-guided chemoradiotherapy of breast cancer. In vitro and in vivo experiments confirmed the high biocompatibility and low toxicity of the nanodroplets.
Chemoradiotherapy with controlled-release nanocarriers such as sono-sensitive nanodroplets (NDs) can enhance the anticancer activity of chemotherapy medicines and reduces normal tissue side effects. In this study, folic acid-functionalized methotrexate-loaded perfluorohexane NDs with alginate shell (FA-MTX/PFH@alginate NDs) were synthesized, characterized, and their potential for ultrasound-guided chemoradiotherapy of breast cancer was investigated in vitro and in vivo. The cancer cell (4T1) viabilities and surviving fractions after NDs and ultrasound treatments were significantly decreased. However, this reduction was much more significant for ultrasound in combination with Xray irradiation. The in vitro and in vivo results confirmed that MTX-loaded NDs are highly biocompatible and they have no significant hemolytic activity and organ toxicity. Furthermore, the in vivo results indicated that the FA-MTX/PFH@alginate NDs were accumulated selectively in the tumor region. In conclusion, FA-functionalized MTX/PFH@alginate NDs have a great theranostic performance for ultrasound-controlled drug delivery in combination with radiotherapy of breast cancer. (c) 2023 Elsevier Inc. All rights reserved.
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