☆ 4.8 Review

Systems toxicology to advance human and environmental hazard assessment: A roadmap for advanced materials

NANO TODAY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Environmental Sciences

Using Machine Learning to make nanomaterials sustainable

Janeck J. Scott-Fordsmand et al.

Summary: Sustainable development is crucial for human survival, and Machine Learning (ML) can play a significant role in supporting more sustainable development by assisting in the Environmental Risk Assessment (ERA) process. ML can be used in various steps of ERA, but there is a lack of guidance and standards for its implementation. To effectively utilize ML in ERA, a strategy should be developed with a focus on data foundations, methodologies, and addressing uncertainties. Historical errors and biases should be acknowledged to prevent their incorporation into ML programming.

SCIENCE OF THE TOTAL ENVIRONMENT (2023)

添加到收藏夹

Article Chemistry, Multidisciplinary

From small to clever: What does the future hold for the safety and sustainability of advanced materials?

Eugenia Valsami-Jones et al.

Summary: This opinion letter discusses the development of a safety framework for new materials and the utilization of nanosafety progress, aiming to engage the wider nanoscience community in addressing these challenges.

NANO TODAY (2022)

添加到收藏夹

Editorial Material Nanoscience & Nanotechnology

Prospects and challenges for FAIR toxicogenomics data

Laura A. Saarimaki et al.

NATURE NANOTECHNOLOGY (2022)

添加到收藏夹

Editorial Material Biotechnology & Applied Microbiology

Nano-pesticides: the lunch-box principle-deadly goodies (semio-chemical functionalised nanoparticles that deliver pesticide only to target species) COMMENT

J. J. Scott-Fordsmand et al.

Summary: The researchers propose a nano-pesticide application approach called the lunch-box or deadly-goodies approach, which aims to attract and kill the target without harming other organisms/species. This method requires a combination of chemical ecological knowledge, nanomaterial techniques, and novel pesticides.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

添加到收藏夹

Article Environmental Sciences

The adverse outcome pathway (AOP) of estrogen interference effect induced by triphenyl phosphate (TPP): Integrated multi-omics and molecular dynamics approaches

Ruining Guan et al.

Summary: This study analyzed the estrogen interference effect of Triphenyl phosphate (TPP) mediated by G protein-coupled estrogen receptor (GPER) using transcriptomic and proteomic methods. The results showed that TPP can regulate the response of key GPER signaling factors and activate downstream pathways, leading to abnormal cell processes and ultimately causing the estrogen interference effect.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

添加到收藏夹

Article Engineering, Environmental

High throughput data-based, toxicity pathway-oriented development of a quantitative adverse outcome pathway network linking AHR activation to lung damages

Yuan Jin et al.

Summary: This study developed a highly reliable AOP model concerning human health, validated and quantitatively evaluated it, and conducted targeted bioassays to further understand cellular responses. Through these research efforts, a comprehensive AOP network was established, providing valuable insights for risk assessment.

JOURNAL OF HAZARDOUS MATERIALS (2022)

添加到收藏夹

Review Genetics & Heredity

Organoids for toxicology and genetic toxicology: applications with drugs and prospects for environmental carcinogenesis

Angela L. Caipa Garcia et al.

Summary: Advances in three-dimensional cell culture technology have allowed the development of organoids, which have proven useful for studying organ development, disease, toxicology, and drug screening. Organoids derived from pluripotent stem cells have greater complexity compared to those derived from adult stem cells. These organoids have been beneficial for pre-clinical testing of personalized treatments and in developing large toxicity and efficacy screens. They have also shown promise in environmental and genetic toxicology studies, providing responses similar to those observed in primary tissues and in vivo models.

MUTAGENESIS (2022)

添加到收藏夹

Review Genetics & Heredity

Human organs-on-chips for disease modelling, drug development and personalized medicine

Donald E. Ingber

Summary: This Review discusses the types of single and multiple human organ-on-a-chip (organ chip) microfluidic devices and their diverse applications for disease modeling, drug development, and personalized medicine. It also addresses the challenges that must be overcome for organ chips to reach their full potential and discusses recent advances in the field.

NATURE REVIEWS GENETICS (2022)

添加到收藏夹

Article Medicine, Legal

R-ODAF: Omics data analysis framework for regulatory application

Marcha C. T. Verheijen et al.

Summary: Despite the widespread use of transcriptomics technologies in toxicology research, the acceptance of the data for regulatory purposes is limited due to the lack of reproducibility and differences in data processing. To address this issue and enhance the credibility of the data, we propose a user-friendly pipeline called R-ODAF for analyzing raw transcriptomics data and also provide additional statistical steps to remove false positives.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Biomarkers of nanomaterials hazard from multi-layer data

Vittorio Fortino et al.

Summary: This study presents a predictive computational framework based on the molecular and phenotypic effects of engineered nanomaterials (ENMs) to predict their toxicity. The researchers identified mRNA-based toxicity markers and validated them in multiple independent datasets.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Insight into 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced disruption of zebrafish spermatogenesis via single cell RNA-seq

Alex Haimbaugh et al.

Summary: This study investigates the potential effects of early-life exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on zebrafish sexual development. Using single-cell RNA-seq, the researchers found that TCDD exposure resulted in changes in the quantity of different cell types in the adult zebrafish testes, supporting the mechanism of TCDD-induced male infertility.

PNAS NEXUS (2022)

添加到收藏夹

Review Immunology

The current landscape of single-cell transcriptomics for cancer immunotherapy

Puneeth Guruprasad et al.

Summary: Emerging single-cell RNA sequencing technologies provide unprecedented insights into the genetic makeup of tumors and immune cells, allowing for a deeper understanding of their roles and interactions during immunotherapy. This knowledge is crucial for identifying new therapeutic targets and improving the efficacy of immunotherapies.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

添加到收藏夹

Article Engineering, Environmental

Con fi rmatory assays for transient changes of omics in soil invertebrates - Copper materials in a multigenerational exposure

Rita C. Bicho et al.

Summary: The environmental risk assessment based on chronic and longer term exposure effects is highly relevant. This study aimed to investigate the long term effects of Cu materials on biological organisms through histology and immunohistochemistry, integrating all levels of biological organization onto an adverse outcome pathway framework. The study revealed both similar and different stress responses caused by CuO NMs and CuCl2 at various levels of biological organization.

JOURNAL OF HAZARDOUS MATERIALS (2021)

添加到收藏夹

Article Environmental Sciences

Nanopharmaceuticals (Au-NPs) after use: Experiences with a complex higher tier test design simulating environmental fate and effect

Kerstin Hund-Rinke et al.

Summary: The study aimed to investigate the realistic exposure scenario for metallic nanoparticles in pharmaceutical products and their release into the environment after treatment in WWTPs. Testing of the ecotoxicological effects of gold nanoparticles in aquatic and soil ecosystems showed that the test approach was suitable for evaluating the toxicity of nanomaterials.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

添加到收藏夹

Article Environmental Sciences

Multiomics assessment in Enchytraeus crypticus exposed to Ag nanomaterials (Ag NM300K) and ions (AgNO3) - Metabolomics, proteomics (& transcriptomics)

Vera L. Maria et al.

Summary: Silver nanomaterials are widely used and studied, and in this study, the differential impact of AgNM300K and AgNO3 on protein and metabolite expression in Enchytraeus crypticus was assessed using high-throughput techniques. Results showed that the two materials elicited different responses in biological pathways, with AgNO3 causing a dose response increase of proteins/metabolites and NM300K causing more upregulation at lower concentrations. This study contributes to understanding the molecular mechanisms underlying the effects of silver nanomaterials on organisms.

ENVIRONMENTAL POLLUTION (2021)

添加到收藏夹

Review Environmental Sciences

Towards safe and sustainable innovation in nanotechnology: State -of -play for smart nanomaterials

Stefania Gottardo et al.

Summary: The European Green Deal and other related policies aim to promote a sustainable, fair, and inclusive EU economy, requiring new materials and products to be safe and sustainable in addition to being functional and cost-effective. Smart nanomaterials, which actively respond to external stimuli, may bring new challenges in safety and sustainability assessment when applied in agriculture, food, and cosmetics industries.

NANOIMPACT (2021)

添加到收藏夹

Article Environmental Sciences

Plastic pollution - A case study with Enchytraeus crypticus - From micro-to nanoplastics

Monica J. B. Amorim et al.

Summary: The concern about microplastic and nanoplastic in the environment highlights the need to reassess the hazard assessment of plastic fragments, suggesting that expanding the scope and duration of tests may increase their value.

ENVIRONMENTAL POLLUTION (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Alternative test methods for (nano)materials hazards assessment: Challenges and recommendations for regulatory preparedness

Susana I. L. Gomes et al.

Summary: The article discusses the work of standardization organizations in hazard assessment, the challenges posed by new materials, and the support from regulatory bodies for developing New Approach Methodologies. It summarizes best practices and test design guidelines for assessing hazards of Nanomaterials in terrestrial environments.

NANO TODAY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Toxicogenomic Profiling of 28 Nanomaterials in Mouse Airways

Pia A. S. Kinaret et al.

Summary: Toxicogenomics utilizes computational methods to map molecular events and biological processes, and in this study, the transcriptomic and immunopathological changes associated with airway exposure to a variety of engineered nanomaterials (ENM) were investigated. The results show that surface modification and core chemistry of ENM can have varying effects on airway toxicity, and a subset of shared differentially expressed genes can help cluster these ENM according to their toxicity levels. This study provides valuable information for developing predictive models for ENM toxicity.

ADVANCED SCIENCE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Manually curated transcriptomics data collection for toxicogenomic assessment of engineered nanomaterials

Laura Aliisa Saarimaki et al.

Summary: Toxicogenomics is increasingly used to understand the toxicity mechanisms of engineered nanomaterials, but a unified collection of transcriptomics data for ENMs is currently lacking. A curated dataset from human, mouse, and rat exposures to ENMs has been compiled to improve accessibility and reusability of the data.

SCIENTIFIC DATA (2021)

添加到收藏夹

Review Genetics & Heredity

Human Organoids for Predictive Toxicology Research and Drug Development

Toshikatsu Matsui et al.

Summary: Organoids, three-dimensional structures fabricated in vitro, mimic complex microenvironments and physiological functions, bridging the gap between animals and humans in research. In toxicology and drug development, human organoids offer new possibilities by overcoming limitations of current models.

FRONTIERS IN GENETICS (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Foliage adhesion and interactions with particulate delivery systems for plant nanobionics and intelligent agriculture

Renato Grillo et al.

Summary: The constantly increasing global food demand has led to innovative agricultural actions aimed at surpassing current production levels. The predicted near-future food security scenario is alarming, with nano-enabled agriculture expected to increase crop yields and limit losses to pathogens and pests through real-time sensing and controlled delivery.

NANO TODAY (2021)

添加到收藏夹

Article Environmental Sciences

The stochastic association of nanoparticles with algae at the cellular level: Effects of NOM, particle size and particle shape

Fazel Abdolahpur Monikh et al.

Summary: This study found that the association of gold nanoparticles with algal cells follows a random probability and less than 45% of the cell population accumulated nanoparticles on their surface after 72 hours of exposure. The distribution of nanoparticles within algal cells was heterogeneous, with some cells having significantly higher numbers of nanoparticles compared to others. The presence of natural organic matter coating on the nanoparticles decreased the percentage of cells containing nanoparticles, except for one specific size of the nanoparticles.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

添加到收藏夹

Article Veterinary Sciences

Annelid genomes: Enchytraeus crypticus, a soil model for the innate (and primed) immune system

Monica J. B. Amorim et al.

Summary: The Enchytraeus crypticus, a soil-dwelling annelid worm, has been used as an ecotoxicology model for over 20 years. Its first high-quality reference genome reveals significant expansions of gene families related to regeneration, innate immune system, and stress response. The presence of ACE homolog in E. crypticus suggests its potential as a model for studying interactions between regeneration, innate immune system, and aging-dependent decline.

LAB ANIMAL (2021)

添加到收藏夹

Article Nanoscience & Nanotechnology

Towards FAIR nanosafety data

Nina Jeliazkova et al.

Summary: The proposal of a FAIR-aligned Nanosafety Data Interface aims to improve findability, accessibility, and interoperability of nanosafety data, providing a path towards standardized and optimized use of existing data to promote safe and sustainable nanotechnology.

NATURE NANOTECHNOLOGY (2021)

添加到收藏夹

Review Genetics & Heredity

Trends in the Application of Omics to Ecotoxicology and Stress Ecology

Joshua Niklas Ebner

Summary: Understanding how environmental changes impact the Earth's biome is crucial, with ecotoxicology and stress ecology playing key roles. Advancements in high-throughput omics technologies allow for measurement of molecular changes across different levels of biological organization. The literature trends suggest that more stressors are studied each year than species, highlighting the importance of cross-species comparisons in integrating omics information.

GENES (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Analysis of Nanotoxicity with Integrated Omics and Mechanobiology

Tae Hwan Shin et al.

Summary: Nanoparticles in biomedical applications offer advantages due to their small size, but evaluating their potential adverse effects on health is necessary and challenging. Omics approaches, in combination with machine learning techniques, provide a more comprehensive and sensitive way to assess nanotoxicity. Additionally, mechanobiology methods can be applied to evaluate the biophysical changes induced by nanoparticles, enhancing the overall understanding of their safety implications.

NANOMATERIALS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Machine learning and materials modelling interpretation of in vivo toxicological response to TiO2 nanoparticles library (UV and non-UV exposure)

Susana I. L. Gomes et al.

Summary: The study aimed to evaluate the effects of Fe-doped TiO2 NPs on soil invertebrates and investigate the influence of different NPs characteristics on their effects. The findings revealed that toxicity of TiO2 NPs decreased under UV exposure conditions, and short-term water exposure induced lasting biological responses even after longer-term recovery.

NANOSCALE (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Toxicokinetics of Ag (nano)materials in the soil model Enchytraeus crypticus (Oligochaeta) - impact of aging and concentration

Fatima C. F. Santos et al.

Summary: This study assessed the kinetics of Ag nanomaterials and AgNO3 in soil invertebrates, finding that the uptake of Ag increased with time in enchytraeids but decreased when they were transferred to clean soil.

ENVIRONMENTAL SCIENCE-NANO (2021)

添加到收藏夹

Article Environmental Sciences

Embryotoxicity of silver nanomaterials (Ag NM300k) in the soil invertebrate Enchytraeus crypticus - Functional assay detects Ca channels shutdown

Rita C. Bicho et al.

Summary: The study revealed that silver affects the embryonic development of the soil invertebrate E. crypticus, especially during the blastula stage. Silver impacts calcium metabolism during embryonic development, with different effects for silver nitrate and Ag NM300K, leading to irreversible consequences and termination of embryonic development.

NANOIMPACT (2021)

添加到收藏夹

Article Nanoscience & Nanotechnology

Corona of Thorns: The Surface Chemistry-Mediated Protein Corona Perturbs the Recognition and Immune Response of Macrophages

Rong Cai et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

添加到收藏夹

Review Toxicology

Prospects and challenges of multi-omics data integration in toxicology

Sebastian Canzler et al.

ARCHIVES OF TOXICOLOGY (2020)

添加到收藏夹

Article Biochemical Research Methods

BMDx: a graphical Shiny application to perform Benchmark Dose analysis for transcriptomics data

Angela Serra et al.

BIOINFORMATICS (2020)

添加到收藏夹

Article Environmental Sciences

Epigenetic effects of (nano)materials in environmental species - Cu case study in Enchytraeus crypticus

Rita C. Bicho et al.

ENVIRONMENT INTERNATIONAL (2020)

添加到收藏夹

Article Environmental Sciences

Novel understanding of toxicity in a life cycle perspective - The mechanisms that lead to population effect - The case of Ag (nano) materials

Natalia P. Rodrigues et al.

ENVIRONMENTAL POLLUTION (2020)

添加到收藏夹

Review Zoology

The Promises and the Challenges of Integrating Multi-Omics and Systems Biology in Comparative Stress Biology

Tonia S. Schwartz

INTEGRATIVE AND COMPARATIVE BIOLOGY (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Carbon Nanomaterials Promote M1/M2 Macrophage Activation

Pia Anneli Sofia Kinaret et al.

SMALL (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Transcriptomics in Toxicogenomics, Part III: Data Modelling for Risk Assessment

Angela Serra et al.

NANOMATERIALS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Multigenerational Exposure to WCCo Nanomaterials-Epigenetics in the Soil Invertebrate Enchytraeus crypticus

Rita C. Bicho et al.

NANOMATERIALS (2020)

添加到收藏夹

Article Biology

TinderMIX: Time-dose integrated modelling of toxicogenomics data

Angela Serra et al.

GIGASCIENCE (2020)

添加到收藏夹

Review Toxicology

Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale

Sabina Halappanavar et al.

PARTICLE AND FIBRE TOXICOLOGY (2020)

添加到收藏夹

Article Environmental Sciences

Environmental hazard testing of nanobiomaterials

M. J. B. Amorim et al.

ENVIRONMENTAL SCIENCES EUROPE (2020)

添加到收藏夹

Article Biochemical Research Methods

Proteomics in Non-model Organisms: A New Analytical Frontier

Michelle Heck et al.

JOURNAL OF PROTEOME RESEARCH (2020)

添加到收藏夹

Review Cell Biology

Human organoids: model systems for human biology and medicine

Jihoon Kim et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

添加到收藏夹

Article Environmental Sciences

Developing an epigenetics model species-From blastula to mature adult, life cycle methylation pro file of Enchytraeus crypticus (Oligochaete)

Rita C. Bicho et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Your Spreadsheets Can Be FAIR: A Tool and FAIRification Workflow for the eNanoMapper Database

Nikolay Kochev et al.

NANOMATERIALS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Semi-Automated Workflow for FAIR Maturity Indicators in the Life Sciences

Ammar Ammar et al.

NANOMATERIALS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Metadata Stewardship in Nanosafety Research: Community-Driven Organisation of Metadata Schemas to Support FAIR Nanoscience Data

Anastasios G. Papadiamantis et al.

NANOMATERIALS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Multiparametric Profiling of Engineered Nanomaterials: Unmasking the Surface Coating Effect

Audrey Gallud et al.

ADVANCED SCIENCE (2020)

添加到收藏夹

Article Biochemical Research Methods

multiGSEA: a GSEA-based pathway enrichment analysis for multi-omics data

Sebastian Canzler et al.

BMC BIOINFORMATICS (2020)

添加到收藏夹

Article Plant Sciences

Transcriptome analysis and differential gene expression profiling of two contrasting quinoa genotypes in response to salt stress

Pibiao Shi et al.

BMC PLANT BIOLOGY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Systematic Review of Multi-Omics Approaches to Investigate Toxicological Effects in Macrophages

Isabel Karkossa et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Article Environmental Sciences

Toxicogenomics analysis of dynamic dose-response in macrophages highlights molecular alterations relevant for multi-walled carbon nanotube-induced lung fibrosis

Laura A. Saarimaki et al.

NANOIMPACT (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Interaction between a nano-formulation of atrazine and rhizosphere bacterial communities: atrazine degradation and bacterial community alterations

Yujia Zhai et al.

ENVIRONMENTAL SCIENCE-NANO (2020)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Eleven grand challenges in single-cell data science

David Laehnemann et al.

GENOME BIOLOGY (2020)

添加到收藏夹

Article Environmental Sciences

High-throughput transcriptomics: Insights into the pathways involved in (nano) nickel toxicity in a key invertebrate test species

Susana I. L. Gomes et al.

ENVIRONMENTAL POLLUTION (2019)

添加到收藏夹

Article Nanoscience & Nanotechnology

Multigenerational exposure to cobalt (CoCl2) and WCCo nanoparticles in Enchytraeus crypticus

Maria J. Ribeiro et al.

NANOTOXICOLOGY (2019)

添加到收藏夹

Review Environmental Sciences

Building and Applying Quantitative Adverse Outcome Pathway Models for Chemical Hazard and Risk Assessment

Edward J. Perkins et al.

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2019)

添加到收藏夹

Review Genetics & Heredity

Single-Cell RNA-Seq Technologies and Related Computational Data Analysis

Geng Chen et al.

FRONTIERS IN GENETICS (2019)

添加到收藏夹

Article Multidisciplinary Sciences

De novo transcriptomes of 14 gammarid individuals for proteogenomic analysis of seven taxonomic groups

Yannick Cogne et al.

SCIENTIFIC DATA (2019)

添加到收藏夹

Article Biochemical Research Methods

uap: reproducible and robust HTS data analysis

Christoph Kaempf et al.

BMC BIOINFORMATICS (2019)

添加到收藏夹

Article Gastroenterology & Hepatology

Generation of hepatobiliary organoids from human induced pluripotent stem cells

Fenfang Wu et al.

JOURNAL OF HEPATOLOGY (2019)

添加到收藏夹

Article Pharmacology & Pharmacy

Development of organoid-based drug metabolism model

Enoch Park et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2019)

添加到收藏夹

Article Environmental Sciences

Silver (nano)materials Cause Genotoxicity In Enchytraeus crypticus, As Determined By the Comet Assay

Vera L. Maria et al.

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2018)

添加到收藏夹

Review Toxicology

Benchmark dose (BMD) modeling: current practice, issues, and challenges

Lynne T. Haber et al.

CRITICAL REVIEWS IN TOXICOLOGY (2018)

添加到收藏夹

Article Engineering, Environmental

Interactions of Soil Species Exposed to CuO NMs are Different From Cu Salt: A Multispecies Test

Luis A. Mendes et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2018)

添加到收藏夹

Article Engineering, Environmental

Environmental Impacts by Fragments Released from Nanoenabled Products: A Multiassay, Multimaterial Exploration by the SUN Approach

Monica J. B. Amorim et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2018)

添加到收藏夹

Article Environmental Sciences

Toxicity of silver nanoparticles to Lumbriculus variegatus is a function of dissolved silver and promoted by low sediment pH

Juho E. Rajala et al.

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2018)

添加到收藏夹

Article Nanoscience & Nanotechnology

High-throughput tool to discriminate effects of NMs (Cu-NPs, Cu-nanowires, CuNO3, and Cu salt aged): transcriptomics in Enchytraeus crypticus

Susana I. L. Gomes et al.

NANOTOXICOLOGY (2018)

添加到收藏夹

Article Nanoscience & Nanotechnology

The Enchytraeus crypticus stress metabolome - CuO NM case study

Vera L. Maria et al.

NANOTOXICOLOGY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

A hybrid gene selection approach to create the S1500+targeted gene sets for use in high-throughput transcriptomics

Deepak Mav et al.

PLOS ONE (2018)

添加到收藏夹

Article Environmental Sciences

Joining the Dots Between Omics and Environmental Management

Kenneth M. Y. Leung

INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT (2018)

添加到收藏夹

Article Environmental Sciences

High-throughput gene expression in soil invertebrate embryos - Mechanisms of Cd toxicity in Enchytraeus crypticus

Susana I. L. Gomes et al.

CHEMOSPHERE (2018)

添加到收藏夹

Article Engineering, Environmental

Fate and Effect of Nano Tungsten Carbide Cobalt (WCCo) in the Soil Environment: Observing a Nanoparticle Specific Toxicity in Enchytraeus crypticus

Maria J. Ribeiro et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2018)

添加到收藏夹

Article Biochemical Research Methods

An Integrated, High-Throughput Strategy for Multiomic Systems Level Analysis

Danielle B. Gutierrez et al.

JOURNAL OF PROTEOME RESEARCH (2018)

添加到收藏夹

Article Biochemical Research Methods

The Proteome of Enchytraeus crypticus-Exposure to CuO Nanomaterial and CuCl2-in Pursue of a Mechanistic Interpretation

Vera L. Maria et al.

PROTEOMICS (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Computational workflow to study the seasonal variation of secondary metabolites in nine different bryophytes

Kristian Peters et al.

SCIENTIFIC DATA (2018)

添加到收藏夹

Article Genetics & Heredity

A Comparison of the TempO-Seq S1500+Platform to RNA-Seq and Microarray Using Rat Liver Mode o Action Samples

Pierre R. Bushel et al.

FRONTIERS IN GENETICS (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Mechanisms of (photo)toxicity of TiO2 nanomaterials (NM103, NM104, NM105): using high-throughput gene expression in Enchytraeus crypticus

Susana I. L. Gomes et al.

NANOSCALE (2018)

添加到收藏夹

Review Environmental Sciences

Nanomaterial exposures for worker, consumer and the general public

Thomas A. J. Kuhlbusch et al.

NANOIMPACT (2018)

添加到收藏夹

Article Environmental Sciences

Multi-omics analysis of ten carbon nanomaterials effects highlights cell type specific patterns of molecular regulation and adaptation

Giovanni Scala et al.

NANOIMPACT (2018)

添加到收藏夹

Review Environmental Sciences

From the exposome to mechanistic understanding of chemical-induced adverse effects

Beate I. Escher et al.

ENVIRONMENT INTERNATIONAL (2017)

添加到收藏夹

Article Environmental Sciences

Effects of copper oxide nanomaterials (CuONMs) are life stage dependent - full life cycle in Enchytraeus crypticus

Rita C. Bicho et al.

ENVIRONMENTAL POLLUTION (2017)

添加到收藏夹

Article Environmental Sciences

Hazard assessment of nickel nanoparticles in soilThe use of a full life cycle test with Enchytraeus crypticus

Fatima C. F. Santos et al.

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2017)

添加到收藏夹

Article Cell Biology

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

Pedro M. Quiros et al.

JOURNAL OF CELL BIOLOGY (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Nanomaterials to microplastics: Swings and roundabouts

J. J. Scott-Fordsmand et al.

NANO TODAY (2017)

添加到收藏夹

Letter Biotechnology & Applied Microbiology

Discovering and linking public omics data sets using the Omics Discovery Index

Yasset Perez-Riverol et al.

NATURE BIOTECHNOLOGY (2017)

添加到收藏夹

Article Medicine, Legal

A generic Transcriptomics Reporting Framework (TRF) for 'omics data processing and analysis

Timothy W. Gant et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2017)

添加到收藏夹

Article Medicine, Legal

The challenge of the application of 'omics technologies in chemicals risk assessment: Background and outlook

Ursula G. Sauer et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2017)

添加到收藏夹

Article Medicine, Legal

Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop

Roland Buesen et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2017)

添加到收藏夹

Article Environmental Sciences

A mixture toxicity approach to predict the toxicity of Ag decorated ZnO nanomaterials

S. L. Azevedo et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2017)

添加到收藏夹

Article Toxicology

The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment

Erica K. Brockmeier et al.

TOXICOLOGICAL SCIENCES (2017)

添加到收藏夹

Article Pharmacology & Pharmacy

Moving into advanced nanomaterials. Toxicity of rutile TiO2 nanoparticles immobilized in nanokaolin nanocomposites on HepG2 cell line

Maria Joao Bessa et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Multigenerational effects of copper nanomaterials (CuONMs) are different of those of CuCl2: exposure in the soil invertebrate Enchytraeus crypticus

Rita C. Bicho et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Review Food Science & Technology

Forthcoming Challenges in Mycotoxins Toxicology Research for Safer Food-A Need for Multi-Omics Approach

Luca Dellafiora et al.

TOXINS (2017)

添加到收藏夹

Article Genetics & Heredity

More Is Better: Recent Progress in Multi-Omics Data Integration Methods

Sijia Huang et al.

Frontiers in Genetics (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Singularity: Scientific containers for mobility of compute

Gregory M. Kurtzer et al.

PLOS ONE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Variation-preserving normalization unveils blind spots in gene expression profiling

Carlos P. Roca et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Article Pharmacology & Pharmacy

Crypt Organoid Culture as an in Vitro Model in Drug Metabolism and Cytotoxicity Studies

Wenqi Lu et al.

DRUG METABOLISM AND DISPOSITION (2017)

添加到收藏夹

Article Oncology

Chromatin Accessibility Landscape of Cutaneous T Cell Lymphoma and Dynamic Response to HDAC Inhibitors

Kun Qu et al.

CANCER CELL (2017)

添加到收藏夹

Article Chemistry, Medicinal

Systems Toxicology: Real World Applications and Opportunities

Thomas Hartung et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

The power of OMICs

Igor Stagljar

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

添加到收藏夹

Article Biochemical Research Methods

Methods for the integration of multi-omics data: mathematical aspects

Matteo Bersanelli et al.

BMC BIOINFORMATICS (2016)

添加到收藏夹

Article Environmental Sciences

Effect assessment of engineered nanoparticles in solid media - Current insight and the way forward

Monica J. B. Amorim et al.

ENVIRONMENTAL POLLUTION (2016)

添加到收藏夹

Article Engineering, Environmental

Effects of Ag nanomaterials (NM300K) and Ag salt (AgNO3) can be discriminated in a full life cycle long term test with Enchytraeus crypticus

Rita C. Bicho et al.

JOURNAL OF HAZARDOUS MATERIALS (2016)

添加到收藏夹

Article Multidisciplinary Sciences

The landscape of accessible chromatin in mammalian preimplantation embryos

Jingyi Wu et al.

NATURE (2016)

添加到收藏夹

Editorial Material Multidisciplinary Sciences

IS THERE A REPRODUCIBILITY CRISIS?

Monya Baker

NATURE (2016)

添加到收藏夹

Article Biology

Systems biology, emergence and antireductionism

Srdjan Kesic

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Authentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1

Edwin Garcia et al.

SCIENTIFIC REPORTS (2016)

添加到收藏夹

Article Environmental Sciences

Cu-nanoparticles ecotoxicity - Explored and explained?

Susana I. L. Gomes et al.

CHEMOSPHERE (2015)

添加到收藏夹

Article Ecology

Enchytraeid Reproduction TestPLUS: hatching, growth and full life cycle test-an optional multi-endpoint test with Enchytraeus crypticus

Rita C. Bicho et al.

ECOTOXICOLOGY (2015)

添加到收藏夹

Article Environmental Sciences

Effect of 10 different TiO2 and ZrO2 (nano)materials on the soil invertebrate Enchytraeus crypticus

Susana I. L. Gomes et al.

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2015)

添加到收藏夹

Review Biochemical Research Methods

Recent findings and technological advances in phosphoproteomics for cells and tissues

Louise von Stechow et al.

EXPERT REVIEW OF PROTEOMICS (2015)

添加到收藏夹

Article Nanoscience & Nanotechnology

The eNanoMapper database for nanomaterial safety information

Nina Jeliazkova et al.

BEILSTEIN JOURNAL OF NANOTECHNOLOGY (2015)

添加到收藏夹

Article Environmental Sciences

Oxidative Stress Mechanisms Caused by Ag Nanoparticles (NM300K) are Different from Those of AgNO3: Effects in the Soil Invertebrate Enchytraeus crypticus

Maria J. Ribeiro et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

Bioinspired Porous ZnO Nanomaterials from Fungal Polysaccharides: Advanced Materials with Unprecedented Low Toxicity in Vitro for Human Cells

Chunping Xu et al.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2015)

添加到收藏夹

Article Mathematical & Computational Biology

eNanoMapper: harnessing ontologies to enable data integration for nanomaterial risk assessment

Janna Hastings et al.

JOURNAL OF BIOMEDICAL SEMANTICS (2015)

添加到收藏夹

Article Multidisciplinary Sciences

How Many Genes Are Expressed in a Transcriptome? Estimation and Results for RNA-Seq

Luis Fernando Garcia-Ortega et al.

PLOS ONE (2015)

添加到收藏夹

Article Biotechnology & Applied Microbiology

A novel ATAC-seq approach reveals lineage-specific reinforcement of the open chromatin landscape via cooperation between BAF and p63

Xiaomin Bao et al.

GENOME BIOLOGY (2015)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Transcriptome assembly and microarray construction for Enchytraeus crypticus, a model oligochaete to assess stress response mechanisms derived from soil conditions

Marta P. Castro-Ferreira et al.

BMC GENOMICS (2014)

添加到收藏夹

Article Chemistry, Medicinal

Systems Toxicology: From Basic Research to Risk Assessment

Shana J. Sturla et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2014)

添加到收藏夹

Review Environmental Sciences

A Framework for the Next Generation of Risk Science

Daniel Krewski et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2014)

添加到收藏夹

Review Biochemical Research Methods

Non-model organisms, a species endangered by proteogenomics

Jean Armengaud et al.

JOURNAL OF PROTEOMICS (2014)

添加到收藏夹

Editorial Material Toxicology

The elephant in the room: reproducibility in toxicology

Craig A. Poland et al.

PARTICLE AND FIBRE TOXICOLOGY (2014)

添加到收藏夹

Article Toxicology

Adverse Outcome Pathway (AOP) Development I: Strategies and Principles

Daniel L. Villeneuve et al.

TOXICOLOGICAL SCIENCES (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Protein Corona Mediates the Impact of Nanomaterials and Slows Amyloid Beta Fibrillation

Morteza Mahmoudi et al.

CHEMBIOCHEM (2013)

添加到收藏夹

Article Engineering, Environmental

Species Differences Take Shape at Nanoparticles: Protein Corona Made of the Native Repertoire Assists Cellular Interaction

Yuya Hayashi et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Challenges and strategies in transcriptome assembly and differential gene expression quantification. A comprehensive in silico assessment of RNA-seq experiments

Nagarjun Vijay et al.

MOLECULAR ECOLOGY (2013)

添加到收藏夹

Review Biochemistry & Molecular Biology

Annotated genes and nonannotated genomes: cross-species use of Gene Ontology in ecology and evolution research

C. R. Primmer et al.

MOLECULAR ECOLOGY (2013)

添加到收藏夹

Article Biochemical Research Methods

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

Jason D. Buenrostro et al.

NATURE METHODS (2013)

添加到收藏夹

Article Pharmacology & Pharmacy

Applying quantitative structure-activity relationship approaches to nanotoxicology: Current status and future potential

David A. Winkler et al.

TOXICOLOGY (2013)

添加到收藏夹

Article Public, Environmental & Occupational Health

Biochemical and histopathological studies of the PTU-induced hypothyroid rat kidney with reference to the ameliorating role of folic acid

Afrah F. Salama et al.

TOXICOLOGY AND INDUSTRIAL HEALTH (2013)

添加到收藏夹

Article Multidisciplinary Sciences

The Ecoresponsive Genome of Daphnia pulex

John K. Colbourne et al.

SCIENCE (2011)

添加到收藏夹

Article Biochemical Research Methods

Transcriptomics in ecotoxicology

Kristin Schirmer et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2010)

添加到收藏夹

Article Endocrinology & Metabolism

Propylthiouracil-Induced Acute Liver Failure: Role of Liver Transplantation

Andres F. Carrion et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2010)

添加到收藏夹

Article Biochemical Research Methods

mRNA-Seq whole-transcriptome analysis of a single cell

Fuchou Tang et al.

NATURE METHODS (2009)

添加到收藏夹

Article Environmental Sciences

Daphnia magna and ecotoxicogenomics:: Gene expression profiles of the anti-ecdysteroidal fungicide fenarimol using energy-, molting- and life stage-related cDNA libraries

Anneleen Soetaert et al.

CHEMOSPHERE (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

Development and application of a brain-specific cDNA microarray for effect evaluation of neuro-active pharmaceuticals in zebrafish (Danio rerio)

K van der Ven et al.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY (2005)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.