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CRISPR/Cas9-based genome editing for multimodal synergistic cancer nanotherapy

NANO TODAY (2023)

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Summary: The CRISPR/Cas9 gene editing technology has made significant progress in oncological research, providing a powerful tool for exploring the mechanism of cancer, establishing tumor models, and studying drug targets.

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Hyuna Sung et al.

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Summary: Cancer nanomedicines offer promising treatment strategies, with photothermal therapy identified as a safe modality for achieving photothermal synergistic cancer therapy and significantly improved benefits.

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Programmable Unlocking Nano-Matryoshka-CRISPR Precisely Reverses Immunosuppression to Unleash Cascade Amplified Adaptive Immune Response

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CRISPR/Cas9-2D Silicene Gene-Editing Nanosystem for Remote NIR-II-Induced Tumor Microenvironment Reprogramming and Augmented Photonic Tumor Ablation

Haohao Yin et al.

Summary: This study successfully addressed the issue of reduced efficacy in photothermal ablation due to upregulation of TXNDC5 gene expression following PTT by constructing a NIR-II light-controlled CRISPR/Cas9 nanosystem based on silicene. The system enabled remote reprogramming of the tumor microenvironment, enhancing photonic tumor ablation effect and significantly improving gene editing efficiency. This approach not only offers a solution to the challenges in photothermal tumor therapy, but also demonstrates the wide biomedical application potential of 2D silicene nanosheets.

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Chenya Zhuo et al.

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Qingfei Zhang et al.

Summary: A chain-shattering Pt(IV)-backboned polymeric nanoplatform has been developed for the targeted delivery of EZH2-targeted CRISPR/Cas9 system in prostate cancer treatment, achieving efficient EZH2 gene disruption and significant downregulation of EZH2 protein expression. The system also led to enhanced apoptosis through H3K27me3 downregulation, resulting in substantial inhibition of prostate cancer cell proliferation and growth repression of subcutaneous xenograft tumors. This innovative nanoplatform not only provides a prospective nanocarrier for CRISPR/Cas9 system delivery, but also broadens the potential of combining gene editing-chemo synergistic cancer therapy.

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Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

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