☆ 4.8 Article

Preventing acute lung injury from progressing to pulmonary fibrosis by maintaining ERS homeostasis through a multistage targeting nanomicelle

NANO TODAY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Editorial Material Nanoscience & Nanotechnology

Nanomedicine hitchhikes on neutrophils to the inflamed lung

Jeonghwan Kim et al.

NATURE NANOTECHNOLOGY (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Reactivation of dysfunctional dendritic cells by a stress-relieving nanosystem resets anti-tumor immune landscape

Yichao Lu et al.

Summary: This study demonstrates that co-inhibiting hyperactivated XBP1 and redundant intracellular ROS through KT-NE can effectively reduce lipid accumulation in dysfunctional lipid-laden TIDCs, leading to the reactivation of TIDCs and restoration of their capacity to expand and stimulate tumor-specific T cells. Additionally, both KT-NE-treated TIDCs (adoptive transfer) and KT-NE itself can significantly improve the efficacy of DC-mediated immunotherapy and reduce tumor burden in malignant ovarian cancer (OvCa)-bearing mice.

NANO TODAY (2022)

添加到收藏夹

Article Respiratory System

Effects of tocilizumab and dexamethasone on the downregulation of proinflammatory cytokines and upregulation of antioxidants in the lungs in oleic acid-induced ARDS

Funda Terzi et al.

Summary: This study aimed to investigate the effects of tocilizumab and dexamethasone on oxidative stress, antioxidant parameters, and cytokine storms in acute lung injury caused by oleic acid. The results showed that tocilizumab and dexamethasone effectively prevented cytokine storms by downregulating the expression of proinflammatory cytokines. They also upregulated antioxidant parameters and exhibited protective effects against cell damage caused by oleic acid.

RESPIRATORY RESEARCH (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Collagen XV Promotes ER Stress-Induced Inflammation through Activating Integrin β1/FAK Signaling Pathway and M1 Macrophage Polarization in Adipose Tissue

Changxing Li et al.

Summary: Collagen XV is highly expressed in adipose tissue and is related to extracellular matrix remodeling, fibrosis, and inflammation in adipose tissue. Overexpression of Col XV in mice leads to infiltration of macrophages into white adipose tissue, exacerbating inflammation and ER stress. Inhibition of the Integrin beta 1/FAK pathway can reverse the effects of Col XV on ER stress and inflammation in adipocytes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Review Cell Biology

Macrophages in Lung Injury, Repair, and Fibrosis

Peiyong Cheng et al.

Summary: Fibrosis progression in the lung can lead to impaired gas exchange, respiratory failure, or even death. Macrophages play a crucial role in response to lung injury, repair, and fibrosis, with their activation and polarization being key factors in the process. Targeting macrophages may offer potential benefits in alleviating pulmonary fibrosis.

CELLS (2021)

添加到收藏夹

Article Engineering, Biomedical

Targeted regulation of lymphocytic ER stress response with an overall immunosuppression to alleviate allograft rejection

Yingying Shi et al.

Summary: Regulating lymphocytic ER unfolded protein response (UPR) could be a potential therapeutic breakthrough in alleviating graft rejection. These findings suggest that lymphocytic IRE1 alpha inactivation attenuates transplant rejection and prolongs graft survival, with limited effector function and memory commitment of host T-8. The combination of IRE1 alpha inhibition with immunosuppressant tacrolimus (FK506) shows an even higher immunosuppressive effect through synergistic regulation of inflammatory transcription factors.

BIOMATERIALS (2021)

添加到收藏夹

Review Nanoscience & Nanotechnology

Nanomedicine-Based Therapeutics to Combat Acute Lung Injury

Shuai Bian et al.

Summary: ALI and ARDS can cause life-threatening respiratory failure with a high mortality rate. Despite some clinical interventions, there is still no completely effective treatment for ALI. Recent advances in nanotechnology may provide new possibilities for the pharmacotherapy of ALI.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Endoplasmic reticulum stress sensor IRE1α propels neutrophil hyperactivity in lupus

Gautam Sule et al.

Summary: The study reveals a role for IRE1 alpha in the hyperactivity of lupus neutrophils, with its inhibition potentially mitigating disease activity and reducing mitochondrial ROS levels. This suggests that targeting NETosis through the IRE1 alpha pathway could be a novel strategy for neutralizing inflammation in lupus.

JOURNAL OF CLINICAL INVESTIGATION (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Dual Inhibition of Endoplasmic Reticulum Stress and Oxidation Stress Manipulates the Polarization of Macrophages under Hypoxia to Sensitize Immunotherapy

Mengshi Jiang et al.

Summary: By inhibiting both ER stress and oxidative stress, M2-tumor associated macrophages (TAMs) can be effectively repolarized, providing significant implications for anti-tumor therapy.

ACS NANO (2021)

添加到收藏夹

Letter Biochemistry & Molecular Biology

A mouse model for SARS-CoV-2-induced acute respiratory distress syndrome

Weiqi Hong et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

添加到收藏夹

Review Immunology

Transforming growth factor-beta in tissue fibrosis

Nikolaos G. Frangogiannis

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Tumor Targeting by αvβ3-Integrin-Specific Lipid Nanoparticles Occurs via Phagocyte Hitchhiking

Alexandros Marios Sofias et al.

ACS NANO (2020)

添加到收藏夹

Article Critical Care Medicine

Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial

Jesus Villar et al.

LANCET RESPIRATORY MEDICINE (2020)

添加到收藏夹

Article Respiratory System

Inhibition of the endoplasmic reticulum (ER) stress-associated IRE-1/XBP-1 pathway alleviates acute lung injury via modulation of macrophage activation

Yanfeng Zhao et al.

JOURNAL OF THORACIC DISEASE (2020)

添加到收藏夹

Article Critical Care Medicine

Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy

Peter M. George et al.

LANCET RESPIRATORY MEDICINE (2020)

添加到收藏夹

Review Cell Biology

Macrophage polarization and its role in the pathogenesis of acute lung injury/acute respiratory distress syndrome

Xuxin Chen et al.

INFLAMMATION RESEARCH (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Appropriate Delivery of the CRISPR/Cas9 System through the Nonlysosomal Route: Application for Therapeutic Gene Editing

Hang Yin et al.

ADVANCED SCIENCE (2020)

添加到收藏夹

Article Medicine, General & Internal

Unfolded Protein Response in Lung Health and Disease

Nektarios Barabutis

FRONTIERS IN MEDICINE (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival

Alyssa Batista et al.

PLOS BIOLOGY (2020)

添加到收藏夹

Review Critical Care Medicine

Pharmacological principles guiding prolonged glucocorticoid treatment in ARDS

Gianfranco Umberto Meduri et al.

INTENSIVE CARE MEDICINE (2020)

添加到收藏夹

Review Urology & Nephrology

Macrophages: versatile players in renal inflammation and fibrosis

Patrick Ming-Kuen Tang et al.

NATURE REVIEWS NEPHROLOGY (2019)

添加到收藏夹

Article Medicine, General & Internal

Acute respiratory distress syndrome

Michael A. Matthay et al.

NATURE REVIEWS DISEASE PRIMERS (2019)

添加到收藏夹

Review Critical Care Medicine

Pathogenesis of Acute Respiratory Distress Syndrome

Laura A. Huppert et al.

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

添加到收藏夹

Article Pharmacology & Pharmacy

MKP-1 promotes anti-inflammatory M(IL-4/IL-13) macrophage phenotype and mediates the anti-inflammatory effects of glucocorticoids

Antti Pemmari et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2019)

添加到收藏夹

Article Engineering, Biomedical

Suppress orthotopic colon cancer and its metastasis through exact targeting and highly selective drug release by a smart nanomicelle

Chunqi Zhu et al.

BIOMATERIALS (2018)

添加到收藏夹

Review Medicine, General & Internal

Acute Respiratory Distress Syndrome Advances in Diagnosis and Treatment

Eddy Fan et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)

添加到收藏夹

Review Respiratory System

Macrophages: friend or foe in idiopathic pulmonary fibrosis?

Lei Zhang et al.

RESPIRATORY RESEARCH (2018)

添加到收藏夹

Article Nanoscience & Nanotechnology

Specifically Increased Paclitaxel Release in Tumor and Synergetic Therapy by a Hyaluronic Acid-Tocopherol Nanomicelle

Hanbo Zhang et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

添加到收藏夹

Article Critical Care Medicine

Preadmission Oral Corticosteroids Are Associated With Reduced Risk of Acute Respiratory Distress Syndrome in Critically Ill Adults With Sepsis

Andrew C. McKown et al.

CRITICAL CARE MEDICINE (2017)

添加到收藏夹

Article Immunology

The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity

Bo Shan et al.

NATURE IMMUNOLOGY (2017)

添加到收藏夹

Article Immunology

Endoplasmic Reticulum Stress of Neutrophils Is Required for Ischemia/Reperfusion-Induced Acute Lung Injury

Rong Hu et al.

JOURNAL OF IMMUNOLOGY (2015)

添加到收藏夹

Article Immunology

Transcription Factors STAT6 and KLF4 Implement Macrophage Polarization via the Dual Catalytic Powers of MCPIP

Nidhi Kapoor et al.

JOURNAL OF IMMUNOLOGY (2015)

添加到收藏夹

Review Medicine, Research & Experimental

PPARγ and the Innate Immune System Mediate the Resolution of Inflammation

Amanda Croasdell et al.

PPAR RESEARCH (2015)

添加到收藏夹

Review Chemistry, Multidisciplinary

Cell-mediated delivery of nanoparticles: Taking advantage of circulatory cells to target nanoparticles

Aaron C. Anselmo et al.

JOURNAL OF CONTROLLED RELEASE (2014)

添加到收藏夹

Article Oncology

Targeting ER stress induced apoptosis and inflammation in cancer

Tom Verfaillie et al.

CANCER LETTERS (2013)

添加到收藏夹

Article Respiratory System

Dexamethasone in patients with acute lung injury from acute monocytic leukaemia

E. Azoulay et al.

EUROPEAN RESPIRATORY JOURNAL (2012)

添加到收藏夹

Article Medicine, General & Internal

Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000

Li Liu et al.

LANCET (2012)

添加到收藏夹

Article Chemistry, Multidisciplinary

Cell-Based Drug Delivery Devices Using Phagocytosis-Resistant Backpacks

Nishit Doshi et al.

ADVANCED MATERIALS (2011)

添加到收藏夹

Article Multidisciplinary Sciences

Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs

William E. Lawson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

添加到收藏夹

Article Physiology

Modulation of glucocorticoid receptor expression, inflammation, and cell apoptosis in septic guinea pig lungs using methylprednisolone

Koki Kamiyama et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2008)

添加到收藏夹

Article Biochemistry & Molecular Biology

XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

Arthur Kaser et al.

CELL (2008)

添加到收藏夹

Article Cell Biology

Differentiation of human monocytes in vitro with granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor produces distinct changes in cGMP phosphodiesterase expression

AT Bender et al.

CELLULAR SIGNALLING (2004)

添加到收藏夹

Article Multidisciplinary Sciences

Resolution of lung inflammation by CD44

P Teder et al.

SCIENCE (2002)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.