☆ 4.8 Review

Native and engineered exosomes for inflamatory disease

NANO RESEARCH (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Nanoscience & Nanotechnology

HACE2-Exosome-Based Nano-Bait for Concurrent SARS-CoV-2 Trapping and Antioxidant Therapy

Xiaoyi Ma et al.

Summary: This study developed a nano-bait strategy using exosome-sheathed polydopamine nanoparticles to inhibit SARS-CoV-2 infection and alleviate inflammation. The nano-bait competes with ACE2-expressing cells for viral binding and reduces inflammatory cytokines through oxidative stress mediation. The HACE2-exosome based nano-bait shows promising potential as a robust antiviral nanotherapeutics for COVID-19.

ACS APPLIED MATERIALS & INTERFACES (2022)

添加到收藏夹

Article Engineering, Biomedical

Exosomes-loaded thermosensitive hydrogels for corneal epithelium and stroma regeneration

Qiaomei Tang et al.

Summary: In this study, a novel approach based on exosomes and a thermosensitive hydrogel was developed for the treatment of corneal diseases. This method effectively reduces scar formation and accelerates the healing process by promoting the repair of damaged corneal epithelium and stromal layer.

BIOMATERIALS (2022)

添加到收藏夹

Article Immunology

Mesenchymal Stem Cells Derived Extracellular Vesicles Alleviate Traumatic Hemorrhagic Shock Induced Hepatic Injury via IL-10/PTPN22-Mediated M2 Kupffer Cell Polarization

Yunwei Zhang et al.

Summary: In this study, it was discovered that mesenchymal stem cells (MSCs) can attenuate hepatic injury and inflammation caused by traumatic hemorrhagic shock (THS). Interleukin 10 (IL-10) plays a crucial role in this protective effect, and it is carried and delivered by MSC-derived extracellular vesicles (MSC-EVs). These EVs containing IL-10 mainly accumulate in the liver during THS, where they are captured by Kupffer cells and induce the expression of PTPN22, shifting Kupffer cells to an anti-inflammatory phenotype and mitigating liver inflammation and injury.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Review Immunology

Pathogenic and Potential Therapeutic Roles of Exosomes Derived From Immune Cells in Liver Diseases

Leyu Zhou et al.

Summary: Liver diseases have a significant impact on patients worldwide, and current treatment options are inadequate and may have strong side effects. Exosomes, small membrane vesicles derived from different immune cells, play an important role in the pathogenesis, diagnosis, prognosis, and treatment of liver diseases.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Young fibroblast-derived exosomal microRNA-125b transfers beneficial effects on aged cutaneous wound healing

Wenzheng Xia et al.

Summary: Aged skin wounds heal poorly due to impaired migration and differentiation of fibroblasts, as well as reduced extracellular matrix deposition. Supplementing wounds with exosomes from young fibroblasts, particularly miR-125b, can promote myofibroblast increase and wound healing in aged individuals, thus counteracting aging.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Increased BMSC exosomal miR-140-3p alleviates bone degradation and promotes bone restoration by targeting Plxnb1 in diabetic rats

Ning Wang et al.

Summary: This study found that exosomes derived from diabetes mellitus BMSCs had lower osteogenic potential in bone defect repair compared to exosomes derived from normal BMSCs. The study also found that the level of miR-140-3p was significantly altered in exosomes derived from BMSCs, ADSCs, and serum from DM rats. Upregulating miR-140-3p promoted the differentiation of DM BMSCs into osteoblasts.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Curcumin primed ADMSCs derived small extracellular vesicle exert enhanced protective effects on osteoarthritis by inhibiting oxidative stress and chondrocyte apoptosis

Chen Xu et al.

Summary: In this study, curcumin was loaded into adipose tissue-derived mesenchymal stem cells-derived small extracellular vesicles (sEV-CUR) to protect and repair articular cartilage in osteoarthritis. The results showed that sEV-CUR effectively reduced oxidative stress and chondrocyte apoptosis in vitro and in an animal model of osteoarthritis, suggesting its potential as a therapeutic option for osteoarthritis.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

添加到收藏夹

Article Biotechnology & Applied Microbiology

GelMA/PEGDA microneedles patch loaded with HUVECs-derived exosomes and Tazarotene promote diabetic wound healing

Meng Yuan et al.

Summary: Clinical work and research on diabetic wound repair are challenging, and conventional wound dressings have limited efficacy. Sustained release of biomolecules from biological wound dressings, such as cell-derived exosomes, shows promise for wound healing. A methacrylate gelatin microneedle patch was developed to achieve transdermal and controlled release of exosomes and tazarotene for diabetic wound repair. The patch demonstrated therapeutic effects by promoting cell migration and angiogenesis.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Triamcinolone acetonide-loaded nanoparticles encapsulated by CD90+ MCSs-derived microvesicles drive anti-inflammatory properties and promote cartilage regeneration after osteoarthritis

Yuanlong Li et al.

Summary: This study developed CD90(+) MSC-derived micro-vesicle (CD90@MV)-coated nanoparticle (CD90@NP) and validated its chondroprotective effect in rabbit and rat osteoarthritis (OA) models. The results showed that CD90@MV bioactivity was similar to that of CD90(+) MSCs, and T-CD90@NP significantly enhanced cartilage repair compared to TA and CD90(+) MSC treatments in the rabbit OA model. In the rat OA model, T-CD90@NP demonstrated effective anti-inflammatory ability similar to that of TA treatment, and also promoted chondrocyte proliferation, reduced apoptosis, and regulated inflammation through IL-10.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Neutralization of SARS-CoV-2 pseudovirus using ACE2-engineered extracellular vesicles

Canhao Wu et al.

Summary: Developing an effective measure to protect people from COVID-19 is urgent. This study utilized extracellular vesicles with engineered ACE2 receptor to neutralize SARS-CoV-2 and demonstrated its potential in inhibiting viral infection.

ACTA PHARMACEUTICA SINICA B (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Exosomes-Loaded Electroconductive Hydrogel Synergistically Promotes Tissue Repair after Spinal Cord Injury via Immunoregulation and Enhancement of Myelinated Axon Growth

Lei Fan et al.

Summary: Neural tissue-like electroconductive hydrogels loaded with BMSC-exosomes have been developed for the treatment of spinal cord injury, and they show enhanced neural regeneration, reduced inflammation, and improved functional recovery.

ADVANCED SCIENCE (2022)

添加到收藏夹

Article Engineering, Biomedical

Exosomal PD-L1 induces osteogenic differentiation and promotes fracture healing by acting as an immunosuppressant

Ze Lin et al.

Summary: This study demonstrates the use of PD-L1-enriched exosomes for bone fracture repair and highlights the potential of Hydrogel@Exos systems for bone fracture therapy through immune inhibitory effects. The results show that exosomal PD-L1 can inhibit T cell activation and promote osteogenic differentiation of mesenchymal stem cells. Additionally, embedding exosomes in a hydrogel allows for time-released delivery and improves treatment efficacy.

BIOACTIVE MATERIALS (2022)

添加到收藏夹

Review Oncology

Extracellular Vesicles Derived from Mesenchymal Stem Cells: A Potential Biodrug for Acute Respiratory Distress Syndrome Treatment

Hao Sun et al.

Summary: MSC-EVs, derived from mesenchymal stem cells, have shown promise in treating ARDS with therapeutic mechanisms including anti-inflammatory, cell injury repair, alveolar fluid clearance, and microbe clearance. Their potent therapeutic ability and biocompatibility make them an alternative option for treating ARDS.

BIODRUGS (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Human Umbilical Cord Mesenchymal Stem Cell Derived Exosomes Delivered Using Silk Fibroin and Sericin Composite Hydrogel Promote Wound Healing

Chaoshan Han et al.

Summary: Recent research has demonstrated that hydrogels formed by composite biomaterials, particularly those consisting of silk fibroin and silk sericin, exhibit superior performance in tissue repair by promoting wound healing, angiogenesis, and reducing inflammation. These composite hydrogels can serve as an excellent delivery system for exosomes in tissue repair.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

添加到收藏夹

Article Engineering, Biomedical

'Green' nanotherapeutics from tea leaves for orally targeted prevention and alleviation of colon diseases

Menghang Zu et al.

Summary: This study presents a natural nanotherapeutic derived from tea leaves, which possess desirable particle sizes and negative surface charge, and contain a wealth of lipids, functional proteins, and bioactive small molecules. The nanotherapeutics can specifically internalize in macrophages via galactose groups on the surface, showing anti-inflammatory effects and promoting gut microbiota diversity.

BIOMATERIALS (2021)

添加到收藏夹

Article Engineering, Biomedical

High-quality milk exosomes as oral drug delivery system

Jie Zhong et al.

Summary: Exosomes are nano-sized extracellular vesicles secreted by mammalian cells, including milk exosomes which have the potential to cross biological barriers and serve as promising drug delivery tools for oral administration.

BIOMATERIALS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Topical Application of Mesenchymal Stem Cell Exosomes Alleviates the Imiquimod Induced Psoriasis-Like Inflammation

Bin Zhang et al.

Summary: The topical application of MSC exosomes significantly reduced levels of IL-17 and C5b-9 in a mouse model of psoriasis, potentially by inhibiting complement activation and the release of NETs from neutrophils in the stratum corneum.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Review Cell & Tissue Engineering

Advances in mesenchymal stem cell exosomes: a review

Yaya Tang et al.

Summary: Stem cells are valuable in regenerative medicine and disease treatment, but face challenges such as storage limitations and cell senescence. Exosomes, as an alternative, have similar effects to stem cells and offer advantages such as targeted delivery, low immunogenicity, and high repairability.

STEM CELL RESEARCH & THERAPY (2021)

添加到收藏夹

Article Cell & Tissue Engineering

Molecular investigation of adequate sources of mesenchymal stem cells for cell therapy of COVID-19-associated organ failure

Christophe Desterke et al.

Summary: MSCs derived from various sources show different levels of ACE2 expression, with adult bone marrow, adipose tissue, or umbilical cord-derived MSCs having the highest expression. These results are crucial in designing clinical MSC-based stem cell therapies for severe COVID-19 infections in the future.

STEM CELLS TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Review Multidisciplinary Sciences

The spectrum of inflammatory responses

Ruslan Medzhitov

Summary: Inflammation plays a crucial role in maintaining homeostasis and structural integrity of tissues and organs in animals. Recent research has revealed a wide range of biological processes involving inflammatory control, urging for a new framework beyond its traditional roles in defense against infection and injury. New perspectives and research directions are discussed to address the current gaps in understanding inflammation biology.

SCIENCE (2021)

添加到收藏夹

Review Medicine, General & Internal

Therapeutic Features and Updated Clinical Trials of Mesenchymal Stem Cell (MSC)-Derived Exosomes

Byung-Chul Lee et al.

Summary: This article discusses the properties and clinical applications of mesenchymal stem cell-derived exosomes, which exhibit therapeutic features similar to MSCs and hold potential for inducing cell differentiation, immunoregulation, angiogenesis, and tumor suppression.

JOURNAL OF CLINICAL MEDICINE (2021)

添加到收藏夹

Review Gastroenterology & Hepatology

Evidence-based clinical practice guidelines for inflammatory bowel disease 2020

Hiroshi Nakase et al.

Summary: Inflammatory bowel disease (IBD) encompasses chronic or remitting/relapsing inflammatory diseases of the intestinal tract, including ulcerative colitis (UC) and Crohn's disease (CD). The etiology of IBD involves disease susceptibility genes, environmental factors, and intestinal bacteria. Optimal management depends on evidence-based interventions tailored by physicians.

JOURNAL OF GASTROENTEROLOGY (2021)

添加到收藏夹

Review Immunology

Extracellular vesicles in immunomodulation and tumor progression

Carolyn Marar et al.

Summary: Extracellular vesicles play a crucial role in regulating the immune response during tumor progression, serving as mediators of communication between cancer and immune cells. Their diverse molecular cargo can shed light on tumor progression mechanisms, offering diagnostic and prognostic tools for immunologists.

NATURE IMMUNOLOGY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Nitric Oxide Nanomotor Driving Exosomes-Loaded Microneedles for Achilles Tendinopathy Healing

Anlong Liu et al.

Summary: The detachable microneedle array designed in this study effectively delivered exosomes modified by a nitric oxide nanomotor to the injury site, enhancing the accumulation of exosomes and demonstrating significant potential in treating Achilles tendinopathy.

ACS NANO (2021)

添加到收藏夹

Article Engineering, Biomedical

Mononuclear phagocyte system blockade using extracellular vesicles modified with CD47 on membrane surface for myocardial infarction reperfusion injury treatment

Zilun Wei et al.

Summary: The study demonstrated that enhancing the biodistribution of CD47-EVs in the heart could potentially serve as a therapeutic approach to alleviate myocardial ischemia-reperfusion injury.

BIOMATERIALS (2021)

添加到收藏夹

Review Cell Biology

The application of umbilical cord-derived MSCs in cardiovascular diseases

Yueqiu Chen et al.

Summary: Umbilical cord-derived mesenchymal stem cells (UC-MSCs) have advantageous characteristics such as differentiation ability, secretion function, immunoregulatory properties, and low immunogenicity. However, challenges like low survivability and tissue retention in application remain to be addressed.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

添加到收藏夹

Review Nanoscience & Nanotechnology

Extracellular vesicles as a next-generation drug delivery platform

Inge Katrin Herrmann et al.

Summary: Extracellular vesicles play a crucial role in cell-to-cell communication and can serve as drug carriers with advantages over synthetic carriers. However, clinical translation of extracellular vesicle-based therapies remains challenging, requiring further research and development efforts.

NATURE NANOTECHNOLOGY (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Artificial exosomes for translational nanomedicine

Yong-Jiang Li et al.

Summary: Artificial exosomes, produced through nanobiotechnology, have emerged as effective drug delivery carriers and include various types such as nanovesicles, exosome-mimetic, and hybrid exosomes. These artificial exosomes offer solutions to overcome limitations of natural exosomes and are considered powerful alternatives for drug delivery.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Metabolically engineered stem cell-derived exosomes to regulate macrophage heterogeneity in rheumatoid arthritis

Dong Gil You et al.

Summary: Metabolically engineered exosomes have been shown to effectively reprogram macrophages' immune phenotype, demonstrating potential therapeutic efficacy in treating rheumatoid arthritis.

SCIENCE ADVANCES (2021)

添加到收藏夹

Review Cell Biology

Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine

Mangesh D. Hade et al.

Summary: Exosomes are extracellular vesicles secreted by almost all cell types to aid in various cellular functions, including intercellular communication and immune signaling. They carry a multitude of signaling moieties, making them potential candidates for tissue engineering and regenerative medicine. The review highlights the emerging roles and potential applications of exosomes in regenerative medicine, particularly in brain injuries, cardiovascular disease, and COVID-19.

CELLS (2021)

添加到收藏夹

Article Critical Care Medicine

Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury

Yang Jiao et al.

Summary: The study demonstrated that exosomal miR-30d-5p from PMNs contributed to sepsis-related ALI by inducing M1 macrophage polarization and priming macrophage pyroptosis through activating NF-kappa B signaling. These findings suggest a novel mechanism of PMN-M phi interaction in sepsis-related ALI, which may provide new therapeutic strategies in sepsis patients.

CRITICAL CARE (2021)

添加到收藏夹

Article Engineering, Biomedical

Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles

Dhanu Gupta et al.

Summary: This study optimized the loading of two different therapeutic protein receptors onto extracellular vesicles through genetic engineering and protein moiety screening, leading to alleviation of inflammation-related diseases.

NATURE BIOMEDICAL ENGINEERING (2021)

添加到收藏夹

Article Medicine, Research & Experimental

TGF-β loaded exosome enhances ischemic wound healing in vitro and in vivo

Ao Shi et al.

Summary: This study developed a clinical-grade platelet exosome product (PEP) combined with injectable surgical fibrin sealant (TISSEEL) to promote chronic wound healing and skin regeneration. The PEP showed promising results in stimulating cellular activities and enhancing wound healing capacity.

THERANOSTICS (2021)

添加到收藏夹

Review Medicine, Research & Experimental

Engineering exosomes for targeted drug delivery

Yujie Liang et al.

Summary: Exosomes can be engineered through genetic and chemical methods for targeted drug delivery, increasing the local concentration of therapeutics and minimizing side effects.

THERANOSTICS (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

HLSC-Derived Extracellular Vesicles Attenuate Liver Fibrosis and Inflammation in a Murine Model of Non-alcoholic Steatohepatitis

Stefania Bruno et al.

MOLECULAR THERAPY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Mesenchymal stem cell-derived extracellular vesicles alone or in conjunction with a SDKP-conjugated self-assembling peptide improve a rat model of myocardial infarction

Saman Firoozi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

添加到收藏夹

Article Immunology

Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 polarization

Wei Liu et al.

JOURNAL OF NEUROINFLAMMATION (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

The significance of exosomes in the development and treatment of hepatocellular carcinoma

Xin Li et al.

MOLECULAR CANCER (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Extracellular Vesicles Derived from Epidural Fat-Mesenchymal Stem Cells Attenuate NLRP3 Inflammasome Activation and Improve Functional Recovery After Spinal Cord Injury

Jiang-Hu Huang et al.

NEUROCHEMICAL RESEARCH (2020)

添加到收藏夹

Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

Phuong-Uyen C. Dinh et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Cell Biology

Extracellular Vesicles From Hepatocytes Are Therapeutic for Toxin-Mediated Fibrosis and Gene Expression in the Liver

Xinlei Li et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer

Gaofeng Liang et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Transplantation of Human Mesenchymal Stem-Cell-Derived Exosomes Immobilized in an Adhesive Hydrogel for Effective Treatment of Spinal Cord Injury

Liming Li et al.

NANO LETTERS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Exosome-based delivery of super-repressor I kappa B alpha relieves sepsis-associated organ damage and mortality

Hojun Choi et al.

SCIENCE ADVANCES (2020)

添加到收藏夹

Article Cell Biology

Mesenchymal Stromal Cell Secretome for Severe COVID-19 Infections: Premises for the Therapeutic Use

Elia Bari et al.

CELLS (2020)

添加到收藏夹

Article Cell Biology

Exosomes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Promote Epidermal Barrier Repair by Inducing de Novo Synthesis of Ceramides in Atopic Dermatitis

Kyong-Oh Shin et al.

CELLS (2020)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Native and bioengineered extracellular vesicles for cardiovascular therapeutics

Ricardo Cerqueira de Abreu et al.

NATURE REVIEWS CARDIOLOGY (2020)

添加到收藏夹

Article Nanoscience & Nanotechnology

Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy

Yujie Liang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

添加到收藏夹

Review Oncology

Biology and therapeutic potential of mesenchymal stem cell-derived exosomes

Zhou Xunian et al.

CANCER SCIENCE (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Neuron-derived exosomes-transmitted miR-124-3p protect traumatically injured spinal cord by suppressing the activation of neurotoxic microglia and astrocytes

Dongdong Jiang et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Transport of Extracellular Vesicles across the Blood-Brain Barrier: Brain Pharmacokinetics and Effects of Inflammation

William A. Banks et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Article Medicine, General & Internal

Atopic dermatitis

Sinéad M Langan et al.

LANCET (2020)

添加到收藏夹

Article Engineering, Biomedical

MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system

Tian Wang et al.

BIOMATERIALS (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Macrophage-derived extracellular vesicles regulate concanavalin A-induced hepatitis by suppressing macrophage cytokine production

Reo Kawata et al.

TOXICOLOGY (2020)

添加到收藏夹

Article Cell Biology

Small extracellular vesicles derived from human MSCs prevent allergic airway inflammation via immunomodulation on pulmonary macrophages

Shu-Bin Fang et al.

CELL DEATH & DISEASE (2020)

添加到收藏夹

Article Cell & Tissue Engineering

Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis

Lei He et al.

STEM CELL RESEARCH & THERAPY (2020)

添加到收藏夹

Article Cell & Tissue Engineering

Intranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease

Morris Losurdo et al.

STEM CELLS TRANSLATIONAL MEDICINE (2020)

添加到收藏夹

Article Cell Biology

The RNA binding protein FMR1 controls selective exosomal miRNA cargo loading during inflammation

Ann L. Wozniak et al.

JOURNAL OF CELL BIOLOGY (2020)

添加到收藏夹

Review Cell Biology

The COVID-19 pandemic: a global health crisis

Casey A. Pollard et al.

PHYSIOLOGICAL GENOMICS (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Mesenchymal Stem Cell Immunomodulation: Mechanisms and Therapeutic Potential

Na Song et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2020)

添加到收藏夹

Article Nutrition & Dietetics

Cow and Human Milk-Derived Exosomes Ameliorate Colitis in DSS Murine Model

Shimon Reif et al.

NUTRIENTS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

hADSCs derived extracellular vesicles inhibit NLRP3inflammasome activation and dry eye

Chaoqun Yu et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Article Cell Biology

PPARα Inhibition Overcomes Tumor-Derived Exosomal Lipid-Induced Dendritic Cell Dysfunction

Xiaozhe Yin et al.

CELL REPORTS (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Magnetic targeting enhances the cutaneous wound healing effects of human mesenchymal stem cell-derived iron oxide exosomes

Xiuying Li et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells Protect Liver Ischemia/Reperfusion Injury by Reducing CD154 Expression on CD4+T Cells via CCT2

Jun Zheng et al.

ADVANCED SCIENCE (2020)

添加到收藏夹

Review Environmental Sciences

Exosome engineering: Current progress in cargo loading and targeted delivery

Shengyang Fu et al.

NANOIMPACT (2020)

添加到收藏夹

Review Cell Biology

Development of therapeutic antibodies for the treatment of diseases

Ruei-Min Lu et al.

JOURNAL OF BIOMEDICAL SCIENCE (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Milk-Derived Extracellular Vesicles in Inter-Organism, Cross-Species Communication and Drug Delivery

Rahul Sanwlani et al.

PROTEOMES (2020)

添加到收藏夹

Article Biology

Mast cells-derived MiR-223 destroys intestinal barrier function by inhibition of CLDN8 expression in intestinal epithelial cells

Musheng Li et al.

BIOLOGICAL RESEARCH (2020)

添加到收藏夹

Article Cell Biology

Small extracellular vesicles from human adipose-derived stem cells attenuate cartilage degeneration

Chang Hee Woo et al.

JOURNAL OF EXTRACELLULAR VESICLES (2020)

添加到收藏夹

Article Cell Biology

Lactobacillus plantarum-derived extracellular vesicles induce anti-inflammatory M2 macrophage polarization in vitro

Wanil Kim et al.

JOURNAL OF EXTRACELLULAR VESICLES (2020)

添加到收藏夹

Article Geriatrics & Gerontology

Transplantation of ACE2(-) Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia

Zikuan Leng et al.

AGING AND DISEASE (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate rat hepatic ischemia-reperfusion injury by suppressing oxidative stress and neutrophil inflammatory response

Jia Yao et al.

FASEB JOURNAL (2019)

添加到收藏夹

Article Engineering, Biomedical

Mesenchymal stem cell-derived extracellular vesicles and retinal ischemia-reperfusion

Biji Mathew et al.

BIOMATERIALS (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Immune Cell-Derived Extracellular Vesicles - Functions and Therapeutic Applications

Rosanne E. Veerman et al.

TRENDS IN MOLECULAR MEDICINE (2019)

添加到收藏夹

Article Cell & Tissue Engineering

Exosomes derived from umbilical cord mesenchymal stem cells reduce microglia-mediated neuroinflammation in perinatal brain injury

Gierin Thomi et al.

STEM CELL RESEARCH & THERAPY (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Exosomes: biogenesis, biologic function and clinical potential

Yuan Zhang et al.

CELL AND BIOSCIENCE (2019)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Exosome origin determines cell targeting and the transfer of therapeutic nanoparticles towards target cells

Maria Sancho-Albero et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

添加到收藏夹

Article Physiology

Mesenchymal Stromal Cell Derived Extracellular Vesicles Reduce Hypoxia-lschaemia Induced Perinatal Brain Injury

Claudia Sisa et al.

FRONTIERS IN PHYSIOLOGY (2019)

添加到收藏夹

Article Engineering, Biomedical

MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis

Shipin Zhang et al.

BIOMATERIALS (2019)

添加到收藏夹

Review Cell Biology

Mesenchymal stem cell therapy for the treatment of inflammatory diseases: Challenges, opportunities, and future perspectives

Shobha Regmi et al.

EUROPEAN JOURNAL OF CELL BIOLOGY (2019)

添加到收藏夹

Review Cell Biology

Advances in therapeutic applications of extracellular vesicles

Oscar P. B. Wiklander et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

添加到收藏夹

Article Cell Biology

Neural stem cell-derived small extracellular vesicles attenuate apoptosis and neuroinflammation after traumatic spinal cord injury by activating autophagy

Yuluo Rong et al.

CELL DEATH & DISEASE (2019)

添加到收藏夹

Article Engineering, Biomedical

miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis

Jiangyi Wu et al.

BIOMATERIALS (2019)

添加到收藏夹

Article Oncology

Exosomes derived from microRNA-30b-3p-overexpressing mesenchymal stem cells protect against lipopolysaccharide-induced acute lung injury by inhibiting SAA3

Xiaomeng Yi et al.

EXPERIMENTAL CELL RESEARCH (2019)

添加到收藏夹

Article Immunology

Extracellular vesicles derived from bone marrow mesenchymal stem cells attenuate dextran sodium sulfate-induced ulcerative colitis by promoting M2 macrophage polarization

Li Cao et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Calcium chloride enhances the delivery of exosomes

Hyoeun Kim et al.

PLOS ONE (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Needle-Free Injection of Exosomes Derived from Human Dermal Fibroblast Spheroids Ameliorates Skin Photoaging

Shiqi Hu et al.

ACS NANO (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Route to Rheumatoid Arthritis by Macrophage-Derived Microvesicle-Coated Nanoparticles

Ruixiang Li et al.

NANO LETTERS (2019)

添加到收藏夹

Article Medicine, Research & Experimental

Exosomes from mesenchymal stromal cells reduce murine colonic inflammation via a macrophage-dependent mechanism

Huashan Liu et al.

JCI INSIGHT (2019)

添加到收藏夹

Article Medicine, Research & Experimental

Mesenchymal stem cell-derived exosomes as a nanotherapeutic agent for amelioration of inflammation-induced astrocyte alterations in mice

Panpan Xian et al.

THERANOSTICS (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Engineering Extracellular Vesicles with the Tools of Enzyme Prodrug Therapy

Gregor Fuhrmann et al.

ADVANCED MATERIALS (2018)

添加到收藏夹

Review Cell & Tissue Engineering

Mesenchymal Stromal Cells: Clinical Challenges and Therapeutic Opportunities

Jacques Galipeau et al.

CELL STEM CELL (2018)

添加到收藏夹

Article Oncology

Mesenchymal stem cell exosomes promote immunosuppression of regulatory T cells in asthma

Du Yu-mo et al.

EXPERIMENTAL CELL RESEARCH (2018)

添加到收藏夹

Review Immunology

Role of T cell-derived exosomes in immunoregulation

Jian Lu et al.

IMMUNOLOGIC RESEARCH (2018)

添加到收藏夹

Article Cell Biology

Extracellular vesicles derived from human embryonic stem cell-MSCs ameliorate cirrhosis in thioacetamide-induced chronic liver injury

Soura Mardpour et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

添加到收藏夹

Review Chemistry, Multidisciplinary

Microneedles as the technique of drug delivery enhancement in diverse organs and tissues

Alexey S. Rzhevskiy et al.

JOURNAL OF CONTROLLED RELEASE (2018)

添加到收藏夹

Article Biochemical Research Methods

Microfluidic engineering of exosomes: editing cellular messages for precision therapeutics

Qingfu Zhu et al.

LAB ON A CHIP (2018)

添加到收藏夹

Article Materials Science, Biomaterials

hucMSC derived exosomes promote functional recovery in spinal cord injury mice via attenuating inflammation

Guodong Sun et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Aging-associated modifications of collagen affect its degradation by matrix metalloproteinases

Preety Panwar et al.

MATRIX BIOLOGY (2018)

添加到收藏夹

Article Nanoscience & Nanotechnology

Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: in vitro and in vivo evaluations

Myung Soo Kim et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2018)

添加到收藏夹

Article Cell & Tissue Engineering

Exosomes derived from human adipose tissue-derived mesenchymal stem cells alleviate atopic dermatitis

Byong Seung Cho et al.

STEM CELL RESEARCH & THERAPY (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Mesenchymal Stromal/stem Cell-derived Extracellular Vesicles Promote Human Cartilage Regeneration In Vitro

Lucienne A. Vonk et al.

THERANOSTICS (2018)

添加到收藏夹

Article Medicine, Research & Experimental

miR-93-5p-Containing Exosomes Treatment Attenuates Acute Myocardial Infarction-Induced Myocardial Damage

Jiwen Liu et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2018)

添加到收藏夹

Review Immunology

Anti-Inflammatory MicroRNAs and Their Potential for Inflammatory Diseases Treatment

Alireza Tahamtan et al.

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Exosomes Isolated From Human Umbilical Cord Mesenchymal Stem Cells Alleviate Neuroinflammation and Reduce Amyloid-Beta Deposition by Modulating Microglial Activation in Alzheimer's Disease

Mao Ding et al.

NEUROCHEMICAL RESEARCH (2018)

添加到收藏夹

Review Multidisciplinary Sciences

Resolution of chronic inflammatory disease: universal and tissue-specific concepts

Georg Schett et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Article Allergy

Lactobacillus plantarum-derived Extracellular Vesicles Protect Atopic Dermatitis Induced by Staphylococcus aureus-derived Extracellular Vesicles

Min-Hye Kim et al.

ALLERGY ASTHMA & IMMUNOLOGY RESEARCH (2018)

添加到收藏夹

Article Medicine, General & Internal

Extracellular Vesicles Secreted by Human Adipose-derived Stem Cells (hASCs) Improve Survival Rate of Rats with Acute Liver Failure by Releasing lncRNA H19

Yinpeng Jin et al.

EBIOMEDICINE (2018)

添加到收藏夹

Article Cell & Tissue Engineering

Extracellular Vesicles from Amnion-Derived Mesenchymal Stem Cells Ameliorate Hepatic Inflammation and Fibrosis in Rats

Masatsugu Ohara et al.

STEM CELLS INTERNATIONAL (2018)

添加到收藏夹

Review Neurosciences

Inhibition of NF-κB Signaling Pathway by Resveratrol Improves Spinal Cord Injury

Luyao Xu et al.

FRONTIERS IN NEUROSCIENCE (2018)

添加到收藏夹

Article Materials Science, Biomaterials

Erythrocyte-platelet hybrid membranes coating polypyrrol nanoparticles for enhanced delivery and photothermal therapy

Yao Liu et al.

JOURNAL OF MATERIALS CHEMISTRY B (2018)

添加到收藏夹

Review Chemistry, Multidisciplinary

Exosomes: new molecular targets of diseases

Saheli Samanta et al.

ACTA PHARMACOLOGICA SINICA (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Exosome as a Vehicle for Delivery of Membrane Protein Therapeutics, PH20, for Enhanced Tumor Penetration and Antitumor Efficacy

Yeonsun Hong et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

添加到收藏夹

Article Urology & Nephrology

Mesenchymal stem cell-derived extracellular vesicles attenuate kidney inflammation

Alfonso Eirin et al.

KIDNEY INTERNATIONAL (2017)

添加到收藏夹

Article Nanoscience & Nanotechnology

Milk-derived exosomes for oral delivery of paclitaxel

Ashish K. Agrawal et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2017)

添加到收藏夹

Review Cell Biology

Mast cell secretome: Soluble and vesicular components

Krisztina V. Vukman et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Extracellular vesicles derived from T regulatory cells suppress T cell proliferation and prolong allograft survival

Sistiana Aiello et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Bovine milk-derived exosomes from colostrum are enriched with proteins implicated in immune response and growth

Monisha Samuel et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Article Engineering, Biomedical

Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain

Dongfen Yuan et al.

BIOMATERIALS (2017)

添加到收藏夹

Article Engineering, Biomedical

Enhanced photothermal therapy of biomimetic polypyrrole nanoparticles through improving blood flow perfusion

Xuejun Wang et al.

BIOMATERIALS (2017)

添加到收藏夹

Review Chemistry, Multidisciplinary

Engineering exosomes as refined biological nanoplatforms for drug delivery

Xin Luan et al.

ACTA PHARMACOLOGICA SINICA (2017)

添加到收藏夹

Review Respiratory System

Global burden of COPD

Jose Luis Lopez-Campos et al.

RESPIROLOGY (2016)

添加到收藏夹

Article Oncology

DNA in serum extracellular vesicles is stable under different storage conditions

Yang Jin et al.

BMC CANCER (2016)

添加到收藏夹

Review Biochemistry & Molecular Biology

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

Mercedes Tkach et al.

CELL (2016)

添加到收藏夹

Review Chemistry, Multidisciplinary

Good things come in small packages: Overcoming challenges to harness extracellular vesicles for therapeutic delivery

Dominique Ingato et al.

JOURNAL OF CONTROLLED RELEASE (2016)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Exosomes derived from dendritic cells improve cardiac function via activation of CD4+ T lymphocytes after myocardial infarction

Haibo Liu et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2016)

添加到收藏夹

Article Nanoscience & Nanotechnology

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

Myung Soo Kim et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2016)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Resolution of inflammation: a new therapeutic frontier

James N. Fullerton et al.

NATURE REVIEWS DRUG DISCOVERY (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Donor-derived exosomes induce specific regulatory T cells to suppress immune inflammation in the allograft heart

Jiangping Song et al.

SCIENTIFIC REPORTS (2016)

添加到收藏夹

Article Cell Biology

Mesenchymal Stem Cell-Derived Exosomes Improve the Microenvironment of Infarcted Myocardium Contributing to Angiogenesis and Anti-Inflammation

Xiaomei Teng et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

Exosomes as drug delivery vehicles for Parkinson's disease therapy

Matthew J. Haney et al.

JOURNAL OF CONTROLLED RELEASE (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins

Gregor Fuhrmann et al.

JOURNAL OF CONTROLLED RELEASE (2015)

添加到收藏夹

Article Immunology

Immature dendritic cell exosomes suppress experimental autoimmune myasthenia gravis

Ning Bu et al.

JOURNAL OF NEUROIMMUNOLOGY (2015)

添加到收藏夹

Article Urology & Nephrology

AKI Recovery Induced by Mesenchymal Stromal Cell-Derived Extracellular Vesicles Carrying MicroRNAs

Federica Collino et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)

添加到收藏夹

Article Cell Biology

Dendritic-cell exosomes cross-present Toll-like receptor-ligands and activate bystander dendritic cells

Andrea Sobo-Vujanovic et al.

CELLULAR IMMUNOLOGY (2014)

添加到收藏夹

Article Immunology

Exosomes derived from human macrophages suppress endothelial cell migration by controlling integrin trafficking

Hee Doo Lee et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2014)

添加到收藏夹

Article Anesthesiology

Functional significance of macrophage-derived exosomes in inflammation and pain

Marguerite K. McDonald et al.

PAIN (2014)

添加到收藏夹

Review Immunology

Regulatory T cell-derived exosomes: possible therapeutic and diagnostic tools in transplantation

Akansha Agarwal et al.

FRONTIERS IN IMMUNOLOGY (2014)

添加到收藏夹

Review Immunology

Extracellular vesicle profiling and their use as potential disease specific biomarker

Henrike Julich et al.

FRONTIERS IN IMMUNOLOGY (2014)

添加到收藏夹

Article Cell Biology

CD4+CD25+ regulatory T cells-derived exosomes prolonged kidney allograft survival in a rat model

Xuesong Yu et al.

CELLULAR IMMUNOLOGY (2013)

添加到收藏夹

Article Cell Biology

Immature Dendritic Cell-Derived Exosomes: a Promise Subcellular Vaccine for Autoimmunity

Weifan Yin et al.

INFLAMMATION (2013)

添加到收藏夹

Review Cell Biology

Extracellular vesicles: Exosomes, microvesicles, and friends

Graca Raposo et al.

JOURNAL OF CELL BIOLOGY (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor

Xing-Yi Ge et al.

NATURE (2013)

添加到收藏夹

Review Immunology

Regulation of intestinal homeostasis and immunity with probiotic lactobacilli

Peter van Baarlen et al.

TRENDS IN IMMUNOLOGY (2013)

添加到收藏夹

Article Cell Biology

Extracellular membrane vesicles from umbilical cord blood-derived MSC protect against ischemic acute kidney injury, a feature that is lost after inflammatory conditioning

Lotta Kilpinen et al.

JOURNAL OF EXTRACELLULAR VESICLES (2013)

添加到收藏夹

Article Gastroenterology & Hepatology

Circulating Microparticles as Disease-Specific Biomarkers of Severity of Inflammation in Patients With Hepatitis C or Nonalcoholic Steatohepatitis

Miroslaw Kornek et al.

GASTROENTEROLOGY (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Immune-related MicroRNAs are Abundant in Breast Milk Exosomes

Qi Zhou et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2012)

添加到收藏夹

Article Biochemical Research Methods

Bovine milk exosome proteome

Timothy A. Reinhardt et al.

JOURNAL OF PROTEOMICS (2012)

添加到收藏夹

Review Cell & Tissue Engineering

Same or Not the Same? Comparison of Adipose Tissue-Derived Versus Bone Marrow-Derived Mesenchymal Stem and Stromal Cells

Marius Strioga et al.

STEM CELLS AND DEVELOPMENT (2012)

添加到收藏夹

Review Hematology

Adipose-derived stromal cells (ASCs)

Giulio Bassi et al.

TRANSFUSION AND APHERESIS SCIENCE (2012)

添加到收藏夹

Article Immunology

CD4(+) T cell-released exosomes inhibit CD8(+) cytotoxic T-lymphocyte responses and antitumor immunity

Haifeng Zhang et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2011)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Lydia Alvarez-Erviti et al.

NATURE BIOTECHNOLOGY (2011)

添加到收藏夹

Article Multidisciplinary Sciences

Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform

Che-Ming J. Hu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

添加到收藏夹

Article Cell Biology

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

Sonja I. Buschow et al.

IMMUNOLOGY AND CELL BIOLOGY (2010)

添加到收藏夹

Review Cell & Tissue Engineering

Human Bone Marrow and Adipose Tissue Mesenchymal Stem Cells: A User's Guide

Federico Mosna et al.

STEM CELLS AND DEVELOPMENT (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

Mesenchymal stem cells: A promising candidate in regenerative medicine

Ye Chen et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2008)

添加到收藏夹

Article Multidisciplinary Sciences

Mesenchymal Stem Cell-Derived Molecules Reverse Fulminant Hepatic Failure

Biju Parekkadan et al.

PLOS ONE (2007)

添加到收藏夹

Article Cell & Tissue Engineering

Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement

M. Dominici et al.

CYTOTHERAPY (2006)

添加到收藏夹

Article Medicine, General & Internal

Derivation of multipotent mesenchymal precursors from human embryonic stem cells

T Barberi et al.

PLOS MEDICINE (2005)

添加到收藏夹

Article Immunology

Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo

D Skokos et al.

JOURNAL OF IMMUNOLOGY (2003)

添加到收藏夹

Article Hematology

Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli

M Di Nicola et al.

BLOOD (2002)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.