期刊
NANO LETTERS
卷 22, 期 23, 页码 9596-9605出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.2c03732
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类别
资金
- National Natural Science Foundation of China [22275071, 21975098]
- program for JLU Science and Technology Innovative Research Team [2017TD-06]
- State Key Laboratory of Applied Optics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Science
- China Postdoctoral Science Foundation [2020TQ0119, 2020M681046]
- interdisciplinary innovation project of the First Hospital of Jilin University
In this study, a sandwiched plasmonic biosensor was developed for rapid, label-free, and naked-eye detection of targeted biomolecular species, such as SARS-CoV-2 antibodies. The sensor demonstrated a broad dynamic range and low limit of detection.
Clinical serology assays for detecting the antibodies of the virus are time-consuming, are less sensitive/selective, or rely on sophisticated detection instruments. Here, we develop a sandwiched plasmonic biosensor (SPB) for supersensitive thickness-sensing via utilizing the distance dependent electromagnetic coupling in sandwiched plasmonic nanostructures. SPBs quantitatively amplify the thickness changes on the nanoscale range (sensitivity: similar to 2% nm-1) into macroscopically visible signals, thereby enabling the rapid, label-free, and naked-eye detection of targeted biomolecular species (via the thickness change caused by immunobinding events). As a proof of concept, this assay affords a broad dynamic range (7 orders of magnitude) and a low LOD (similar to 0.3 pM), allowing for the extremely accurate SARS-CoV-2 antibody quantification (sensitivity/specificity: 100%/similar to 99%, with a portable optical fiber device). This strategy is suitable for high-throughput multiplexed detection and smartphone-based sensing at the point-of-care, which can be expanded for various sensing applications beyond the fields of viral infections and vaccination.
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