期刊
MOLECULES
卷 28, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/molecules28010049
关键词
modified glassy carbon; ibuprofen; bovine serum albumin; inflammation
In this study, a sensitive, selective, cost-effective, and environmentally benign electrochemical probe was developed for the detection of ibuprofen (IBP) using a glassy carbon electrode modified with Ag-ZnO and MWCNTs. The designed sensing platform was able to detect IBP down to a limit of detection of 28 nM under optimized conditions. The interaction between IBP and bovine serum albumin (BSA) was also investigated, revealing a strong complex formation with a binding constant of 8.7 x 10(13). This is the first reported example of IBP detection and its complexation with BSA.
The current work presents a sensitive, selective, cost-effective, and environmentally benign protocol for the detection of ibuprofen (IBP) by an electrochemical probe made of a glassy carbon electrode modified with Ag-ZnO and MWCNTs. Under optimized conditions, the designed sensing platform was found to sense IBP up to a 28 nM limit of detection. The interaction of IBP with bovine serum albumin (BSA) was investigated by differential pulse voltammetry. IBP-BSA binding parameters such as the binding constant and the stoichiometry of complexation were calculated. The results revealed that IBP and BSA form a single strong complex with a binding constant value of 8.7 x 10(13). To the best of our knowledge, this is the first example that reports not only IBP detection but also its BSA complexation.
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