期刊
MOLECULES
卷 27, 期 24, 页码 -出版社
MDPI
DOI: 10.3390/molecules27248859
关键词
glycosylation; proteins; erythropoietin; monoclonal antibodies
资金
- National Key R & D Program of China
- CAMS Innovation Fund for Medical Sciences (CIFMS) [2018YFE0111400]
- Training Program of the Major Research Plan of National Natural Science Foundation of China [2021-I2M-1-026]
- National Major Scientific and Technological Special Project of China [91853120]
- NIH [2018ZX09711001-005, 2018ZX09711001-013]
- [R01 EB025892]
Therapeutic proteins are increasingly valued for their unique advantages in the treatment of various diseases, but their intrinsic limitations often restrict their wider applications. Glycosylation, as a crucial post-translational modification, has positive effects on protein properties. Glycoengineering, involving changing glycosylation patterns, is expected to be an effective means of improving the performance of therapeutic proteins.
Therapeutic proteins have unique advantages over small-molecule drugs in the treatment of various diseases, such as higher target specificity, stronger pharmacological efficacy and relatively low side effects. These advantages make them increasingly valued in drug development and clinical practice. However, although highly valued, the intrinsic limitations in their physical, chemical and pharmacological properties often restrict their wider applications. As one of the most important post-translational modifications, glycosylation has been shown to exert positive effects on many properties of proteins, including molecular stability, and pharmacodynamic and pharmacokinetic characteristics. Glycoengineering, which involves changing the glycosylation patterns of proteins, is therefore expected to be an effective means of overcoming the problems of therapeutic proteins. In this review, we summarize recent efforts and advances in the glycoengineering of erythropoietin and IgG monoclonal antibodies, with the goals of illustrating the importance of this strategy in improving the performance of therapeutic proteins and providing a brief overview of how glycoengineering is applied to protein-based drugs.
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