期刊
MOLECULES
卷 28, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/molecules28020615
关键词
absolute configurations; biological activity; chiral derivatizing agent; chiral stationary phase; liquid chromatography; Marfey's method; marine resources; cyclopeptides; stereochemistry
Cyclopeptides derived from marine sources are important due to their structural diversity and biological activities. The determination of their absolute configurations is challenging, but can be achieved through acidic hydrolysis and liquid chromatography (LC) analysis. Recent works have identified 91 previously unreported marine-derived cyclopeptides, with many displaying anticancer or antimicrobial activities. LC analysis using Marfey's method was the most frequently employed technique for absolute stereochemical assignment.
Cyclopeptides are considered as one of the most important classes of compounds derived from marine sources, due to their structural diversity and a myriad of their biological and pharmacological activities. Since marine-derived cyclopeptides consist of different amino acids, many of which are non-proteinogenic, they possess various stereogenic centers. In this respect, the structure elucidation of new molecular scaffolds obtained from natural sources, including marine-derived cyclopeptides, can become a very challenging task. The determination of the absolute configurations of the amino acid residues is accomplished, in most cases, by performing acidic hydrolysis, followed by analyses by liquid chromatography (LC). In a continuation with the authors' previous publication, and to analyze the current trends, the present review covers recently published works (from January 2018 to November 2022) regarding new cyclopeptides from marine organisms, with a special focus on their biological/pharmacological activities and the absolute stereochemical assignment of the amino acid residues. Ninety-one unreported marine-derived cyclopeptides were identified during this period, most of which displayed anticancer or antimicrobial activities. Marfey's method, which involves LC, was found to be the most frequently used for this purpose.
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