期刊
MOLECULES
卷 27, 期 23, 页码 -出版社
MDPI
DOI: 10.3390/molecules27238280
关键词
antibacterial; anticancer; antimalarial; antiviral; computer-assisted; drug discovery; lead discovery; natural product
Natural products and their derivatives have shown to be effective drug candidates against various diseases. This paper reviews potent anticancer, anti-HIV, antibacterial, and antimalarial drugs or lead compounds discovered mainly from 2016 to 2022, as well as computer-assisted techniques used in designing new structures based on available natural products.
Natural products and their derivatives have been shown to be effective drug candidates against various diseases for many years. Over a long period of time, nature has produced an abundant and prosperous source pool for novel therapeutic agents with distinctive structures. Major natural-product-based drugs approved for clinical use include anti-infectives and anticancer agents. This paper will review some natural-product-related potent anticancer, anti-HIV, antibacterial and antimalarial drugs or lead compounds mainly discovered from 2016 to 2022. Structurally typical marine bioactive products are also included. Molecular modeling, machine learning, bioinformatics and other computer-assisted techniques that are very important in narrowing down bioactive core structural scaffolds and helping to design new structures to fight against key disease-associated molecular targets based on available natural products are considered and briefly reviewed.
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