Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes (vol 27, 3944, 2022)

Summary: The development of oligonucleotide conjugates for in vivo targeting, particularly GalNAc-oligonucleotides, is an exciting area in oligonucleotide therapeutics. In this study, the authors explore the use of G-rich sequences functionalized with GalNAc to form tetrameric nanostructures that can bind to ASGPR. The study demonstrates the feasibility and potential benefits of using parallel G-quadruplexes for targeting hepatocytes.