Investigating the Mechanisms of Bisdemethoxycurcumin in Ulcerative Colitis: Network Pharmacology and Experimental Verification

Article Medicine, Research & Experimental

Osteoinductive activity of bisdemethoxycurcumin and its synergistic protective effect with human amniotic mesenchymal stem cells against ovariectomy-induced osteoporosis mouse model

Jin-Xing Wei et al.

Summary: Bisdeme-thoxycurcumin (BDMC) can stimulate the differentiation of human amniotic mesenchymal stem cells (hAMSCs) into osteoblasts, potentially serving as an effective adjuvant therapy for osteoporosis.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Environmental Sciences

Bisdemethoxycurcumin suppresses human brain glioblastoma multiforme GBM 8401 cell migration and invasion via affecting NF-κB and MMP-2 and MMP-9 signaling pathway in vitro

Chiung-Ju Chen et al.

Summary: We evaluated the antimetastasis activity of Bisdemethoxycurcumin (BDMC) in human glioblastoma (GBM) cells and found that BDMC may have the potential to inhibit cell migration and invasion in GBM by suppressing key signaling pathways involved in cell proliferation, uptake, and motility.

ENVIRONMENTAL TOXICOLOGY (2022)

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Article Gastroenterology & Hepatology

Fibrinogen/AKT/Microfilament Axis Promotes Colitis by Enhancing Vascular Permeability

Chong Zhang et al.

Summary: The study found that fibrinogen is upregulated in the colon of DSS-treated mice and in patients with ulcerative colitis. Inhibition of fibrinogen significantly alleviated DSS-induced colitis. Fibrinogen regulates colitis by modulating vascular permeability through activating AKT and depolymerizing microfilament, suggesting it as a potential target for anti-colitis treatment.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Article Integrative & Complementary Medicine

Network pharmacology based research into the effect and mechanism of Yinchenhao Decoction against Cholangiocarcinoma

Zhiqiang Chen et al.

Summary: According to network pharmacology strategy and experimental results, Yinchenhao decoction exerts anti-tumor effects through multiple components, targets, and pathways, providing novel ideas for the development of preparations and the treatment of cholangiocarcinoma.

CHINESE MEDICINE (2021)

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Article Plant Sciences

Network pharmacology and pharmacokinetics integrated strategy to investigate the pharmacological mechanism of Xianglian pill on ulcerative colitis

Chang-Shun Liu et al.

Summary: This study evaluated the pharmacological mechanism of Xianglian pill (XLP) in treating ulcerative colitis (UC) through a combination of network pharmacology and pharmacokinetics analysis. The results showed that XLP mainly alleviates UC inflammation by regulating key pathways of the immune system and inhibiting Th17 cell differentiation. Pharmaceutical studies also confirmed the exposure of XLP ingredients in plasma and colon tissue, demonstrating its therapeutic effect on UC.

PHYTOMEDICINE (2021)

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Article Immunology

Efficacy of a Standardized Turmeric Extract Comprised of 70% Bisdemothoxy-Curcumin (REVERC3) Against LPS-Induced Inflammation in RAW264.7 Cells and Carrageenan-Induced Paw Edema

Kuluvar Gouthannchandra et al.

Summary: In this study, bisdemethoxycurcumin (BDMC) was enriched to 70% and named as REVERC3 for the first time, showing significant anti-inflammatory activity in comparison to regular turmeric extract. The results demonstrated that REVERC3 effectively inhibited inflammation processes in both in vitro and in vivo models.

JOURNAL OF INFLAMMATION RESEARCH (2021)

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Article Environmental Sciences

Demethoxycurcumin induces apoptosis in HER2 overexpressing bladder cancer cells through degradation of HER2 and inhibiting the PI3K/Akt pathway

Chien-Chang Kao et al.

Summary: Curcuminoids have shown inhibitory effects on HER2-overexpressing bladder cancer cells, and can be used in combination with chemotherapeutic agents to exhibit additive activity, indicating their potential as a new candidate for anti-tumor drug development.

ENVIRONMENTAL TOXICOLOGY (2021)

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Article Medicine, General & Internal