Molecular Aspects and Therapeutic Implications of Herbal Compounds Targeting Different Types of Cancer

Due to genetic changes in DNA (deoxyribonucleic acid) sequences, cancer continues to be the second most prevalent cause of death. The traditional target-directed approach, which is confronted with the importance of target function in healthy cells, is one of the most significant challenges in anticancer research. Another problem with cancer cells is that they experience various mutations, changes in gene duplication, and chromosomal abnormalities, all of which have a direct influence on the potency of anticancer drugs at different developmental stages. All of these factors combine to make cancer medication development difficult, with low clinical licensure success rates when compared to other therapy categories. The current review focuses on the pathophysiology and molecular aspects of common cancer types. Currently, the available chemotherapeutic drugs, also known as combination chemotherapy, are associated with numerous adverse effects, resulting in the search for herbal-based alternatives that attenuate resistance due to cancer therapy and exert chemo-protective actions. To provide new insights, this review updated the list of key compounds that may enhance the efficacy of cancer treatment.

Automated summary

Due to genetic changes, cancer remains a major cause of death. Anticancer research faces challenges in targeting healthy cells while addressing the importance of target function. Cancer cells undergo various mutations and abnormalities that affect the efficacy of anticancer drugs. With low clinical success rates, finding alternative herbal-based therapies to attenuate resistance and protect against chemotherapy side effects is crucial. This review updates the understanding of common cancer types and presents key compounds that may enhance cancer treatment efficacy.