Smart Pellets for Controlled Delivery of 5-Fluorouracil

Article Polymer Science

Mucilage of Coccinia grandis as an Efficient Natural Polymer-Based Pharmaceutical Excipient

Kumbakonam Balachandran Ilango et al.

Summary: The mucilage extracted from Coccinia grandis shows good physicochemical properties and drug performance, making it a potential material for tablet formulation. It is also a promising disintegrant, performing better than standard disintegrants, and has low cytotoxicity, ensuring safety for human cells.

POLYMERS (2022)

添加到收藏夹

Article

Development and In Vitro Evaluation of a Large-Intestinal Drug Delivery System

Mohammad F. Bayan et al.

Research Journal of Pharmacy and Technology (2022)

添加到收藏夹

Article Engineering, Multidisciplinary

Facile Fabrication of Methyl Gallate Encapsulated Folate ZIF-L Nanoframeworks as a pH Responsive Drug Delivery System for Anti-Biofilm and Anticancer Therapy

Saeed M. M. Marji et al.

Summary: This study highlights the simple synthesis of methyl gallate encapsulated folate-ZIF-L nanoframeworks (MG@Folate ZIF-L) and its potential applications in biomedical field. The nanoframeworks exhibited superior cytotoxic effect and anti-biofilm potential. With the unique physicochemical and biological characteristics, it overcomes the limitations of existing drug delivery systems and shows promising biomedical applications.

BIOMIMETICS (2022)

添加到收藏夹

Article Polymer Science

Development of Polymeric-Based Formulation as Potential Smart Colonic Drug Delivery System

Mohammad F. Bayan et al.

Summary: The study aims to develop a smart drug delivery system based on pH-sensitive polymeric formulations. The system can delay the release of drugs in the stomach and small intestine, while releasing them in the colon, showing promising potential for application.

POLYMERS (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Preparation and Evaluation of Ternary Polymeric Blends for Controlled Release Matrices Containing Weakly Basic Model Drug

Wasfy M. Obeidat et al.

Summary: This study evaluated a ternary mixture of smart polymers for sustained drug release of weakly basic drug, Metronidazole. By adjusting the ratios of sodium alginate and Eudragit (R) polymers, significant modifications in drug release rates were observed, with the potential to control release for up to 12 hours. The findings emphasize the critical role of polymer ratios in determining the controlled release performance.

CURRENT DRUG DELIVERY (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Colon-targeted delivery of tacrolimus using pH-responsive polymeric nanoparticles for murine colitis therapy

Xiaoran Cai et al.

Summary: The study successfully developed an oral nanoparticle delivery system for the effective treatment of inflammatory bowel disease by preparing FK506/HP-β-CD inclusion compounds and adsorbing ES100 and HA onto the nanoparticles loaded with FK506/HP-β-CD through electrostatic interactions. FK506@EHCh NPs displayed promising results in suppressing inflammation and showed potential for targeted treatment of inflammatory bowel disease.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

添加到收藏夹

Article Materials Science, Biomaterials