Azomethine Ylides-Versatile Synthons for Pyrrolidinyl-Heterocyclic Compounds

Azomethine ylides are nitrogen-based three-atom components commonly used in [3+2]-cycloaddition reactions with various unsaturated 2 pi-electron components. These reactions are highly regio- and stereoselective and have attracted the attention of organic chemists with respect to the construction of diverse heterocycles potentially bearing four new contiguous stereogenic centers. This review article complies the most important [3+2]-cycloaddition reactions of azomethine ylides with various olefinic, unsaturated 2 pi-electron components (acyclic, alicyclic, heterocyclic, and exocyclic ones) reported over the past two decades.

Automated summary

Azomethine ylides are frequently used three-atom components in nitrogen-based [3+2]-cycloaddition reactions with a variety of unsaturated 2 pi-electron components. These reactions demonstrate remarkable regio- and stereoselectivity and have attracted organic chemists' interest in constructing diverse heterocycles with four contiguous stereogenic centers. This review article summarizes the significant [3+2]-cycloaddition reactions of azomethine ylides with various olefinic, unsaturated 2 pi-electron components (acyclic, alicyclic, heterocyclic, and exocyclic ones) reported in the past two decades.