☆ 4.6 Review

Recent Progress in Type I Aggregation-Induced Emission Photosensitizers for Photodynamic Therapy

MOLECULES (2023)

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Summary: Research has constructed a all-in-one phototheranostic AlEgen with potential advantages in phototherapy, including high photothermal conversion efficiency and ROS generation. The nanoparticles exhibit outstanding ROS generation properties, with the unique structure and spin-orbit coupling facilitating the phototherapeutic effects.

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Summary: Phototheranostic agents, integrating sensitive in situ fluorescence imaging and effective multi-model synergistic therapy, have emerged as promising tools for cancer theranostics. However, balancing the competitive radiative and nonradiative processes in photon energy transfer remains challenging. In this study, three simple molecules with electron donating-accepting structures were developed. The introduction of an acridinium unit as an electron acceptor led to the formation of TPEDCAc with aggregation-induced second near-infrared emission, high reactive oxygen species generation capability, and excellent photothermal conversion efficiency. The key factors for achieving NIR-II emission and balanced photodynamic/photothermal conversion were found to be large torsional angle and strong electron-withdrawing ability of the acridinium unit. Impressively, TPEDCAc exhibited mitochondria-targeting capability and high performance in in vivo multi-modal cancer theranostics under NIR laser irradiation. This work not only provides a single NIR-II AIE-based multi-modal cancer theranostic system but also inspires new insights into the development of theranostic platforms in the future.

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Summary: In this study, a cationization molecular engineering strategy was used to enhance the generation of reactive oxygen species (ROS) for efficient photodynamic therapy (PDT). The cationization process improved the aggregation-induced emission (AIE) feature, promoted intersystem crossing (ISC) processes, and increased charge transfer and separation ability, leading to the efficient production of ROS, particularly hydroxyl and superoxide radicals. Additionally, the cationic AIE photosensitizers also exhibited specific cancer cell mitochondrial targeting capability, which further improved the efficacy of PDT.

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Xiuli Xu et al.

Summary: The biomimetic aggregation-induced emission (AIE) photosensitizers with antigen-presenting and hitchhiking abilities (DC@AIEdots) were developed by coating dendritic cell (DC) membranes on the nanoaggregates of the AIEgens. This technique can enhance tumor delivery efficiency by about 1.6 times and stimulate in vivo proliferation and activation of T cells. Additionally, a potential application of therapeutic agents targeting lipid droplets for immunotherapy is indicated, providing a new hitchhiking approach for drug delivery.

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