4.6 Article

Development of a Proton-Enhanced ESI UPLC-MS/MS Method for the Determination of Tetrodotoxin

期刊

MOLECULES
卷 27, 期 24, 页码 -

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MDPI
DOI: 10.3390/molecules27248967

关键词

tetrodotoxin; proton-enhanced; UPLC-MS; MS; puffer fish

资金

  1. National Key Research and Development Program of China
  2. [2019YFC1604702]

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The study established a method for accurate and rapid determination of TTX, with good peak shapes, high sensitivity, and low coeluted interferences. It was successfully applied to determine TTX in puffer fish tissue samples.
Tetrodotoxin (TTX) is a kind of low-molecular-weight non-protein neurotoxin. It is one of the most potent neurotoxins found in nature, and it is found in puffer fish and various marine biota. The low sensitivity of previous analytical methods limited their application in puffer fish organ samples. This study established a method for the accurate and fast determination of TTX by reversed ultra-performance liquid chromatography coupled with proton-enhanced electron spray ionization-tandem mass spectrometry. The method yields good peak shapes, high sensitivity and low coeluted interferences. The method was successfully applied to determine TTX in puffer fish tissue samples of about 0.2 g.

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