期刊
MOLECULES
卷 27, 期 23, 页码 -出版社
MDPI
DOI: 10.3390/molecules27238630
关键词
pancreatitis; berberine; polyphenols; pancreatic cancer; in vitro; in vivo
The pancreas plays important roles in maintaining blood glucose homeostasis and digestive enzyme secretion. Pancreatitis can lead to pancreatic dysfunction and increase the risk of pancreatic cancer. Berberine, a natural compound, shows potential effects against pancreatitis and pancreatic cancer, and the underlying mechanisms need further investigation.
The pancreas is a glandular organ with endocrine and exocrine functions necessary for the maintenance of blood glucose homeostasis and secretion of digestive enzymes. Pancreatitis is characterized by inflammation of the pancreas leading to temporary or permanent pancreatic dysfunction. Inflammation and fibrosis caused by chronic pancreatitis exacerbate malignant transformation and significantly increase the risk of developing pancreatic cancer, the world's most aggressive cancer with a 5-year survival rate less than 10%. Berberine (BBR) is a naturally occurring plant-derived polyphenol present in a variety of herbal remedies used in traditional medicine to treat ulcers, infections, jaundice, and inflammation. The current review summarizes the existing in vitro and in vivo evidence on the effects of BBR against pancreatitis and pancreatic cancer with a focus on the signalling mechanisms underlying the effects of BBR.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据