Isolation of Various Flavonoids with TRAIL Resistance-Overcoming Activity from Blumea lacera

Eighteen compounds, including fourteen flavonoids (1-14), one steroid (15), two fatty acids (16,17), and one nitrogen-containing compound (18), were isolated from the methanol extract of the whole Blumea lacera plant collected in Thailand. Compounds 1-11 and 15-17 exhibited tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance-overcoming activity. Among them, bonanzin (2) and cirsilineol (7) had particularly strong TRAIL resistance-overcoming activity, where the IC50 values against the human gastric adenocarcinoma cell line AGS in the presence of TRAIL (100 ng/mL) were 10.7 mu M and 5.9 mu M, respectively.

Automated summary

Eighteen compounds, including fourteen flavonoids, one steroid, two fatty acids, and one nitrogen-containing compound, were isolated from the whole Blumea lacera plant collected in Thailand. Compounds 1-11 and 15-17 showed activity in overcoming tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance. Among them, bonanzin (2) and cirsilineol (7) exhibited particularly strong TRAIL resistance-overcoming activity, with IC50 values of 10.7 μM and 5.9 μM, respectively, against the human gastric adenocarcinoma cell line AGS in the presence of TRAIL (100 ng/mL).