To Affinity and Beyond: A Personal Reflection on the Design and Discovery of Drugs

Faced with new and as yet unmet medical need, the stark underperformance of the pharmaceutical discovery process is well described if not perfectly understood. Driven primarily by profit rather than societal need, the search for new pharmaceutical products-small molecule drugs, biologicals, and vaccines-is neither properly funded nor sufficiently systematic. Many innovative approaches remain significantly underused and severely underappreciated, while dominant methodologies are replete with problems and limitations. Design is a component of drug discovery that is much discussed but seldom realised. In and of itself, technical innovation alone is unlikely to fulfil all the possibilities of drug discovery if the necessary underlying infrastructure remains unaltered. A fundamental revision in attitudes, with greater reliance on design powered by computational approaches, as well as a move away from the commercial imperative, is thus essential to capitalise fully on the potential of pharmaceutical intervention in healthcare.

Automated summary

The underperformance of the pharmaceutical discovery process is mainly due to profit-driven rather than society-driven search for new pharmaceutical products. Insufficient funding and lack of systematic approaches result in underuse of innovative methods and limitations of dominant methodologies. To fully capitalize on the potential of pharmaceutical intervention, a fundamental shift in attitude towards reliance on computational approaches and moving away from commercial imperatives is essential.