期刊
MOLECULES
卷 27, 期 21, 页码 -出版社
MDPI
DOI: 10.3390/molecules27217558
关键词
Maerua siamensis; Capparaceae; indole alkaloids; nitric oxide inhibition
资金
- 100th Anniversary Chulalongkorn University Fund
- CU Graduate school thesis grant
- Natural Products and Nanoparticles Research Unit, Chulalongkorn University
Eight new indole alkaloids were isolated from Maerua siamensis roots, showing anti-inflammatory activity, with maeruabisindole B exhibiting the most significant inhibition of nitric oxide production.
Maerua siamensis (Capparaceae) roots are used for treating pain and inflammation in traditional Thai medicine. Eight new indole alkaloids, named maeruanitriles A and B, maeroximes A-C, and maeruabisindoles A-C, were isolated from them. Spectroscopic methods and computational analysis were applied to determine the structure of the isolated compounds. Maeroximes A-C possesses an unusual O-methyloxime moiety. The bisindole alkaloid maeruabisindoles A and B possess a rare azete ring, whereas maeruabisindole C is the first indolo[3,2-b]carbazole derivative found in this plant family. Five compounds [maeruanitriles A and B, maeroxime C, maeruabisindoles B, and C] displayed anti-inflammatory activity by inhibiting nitric oxide (NO) production in the lipopolysaccharide-induced RAW 264.7 cells. Maeruabisindole B was the most active inhibitor of NO production, with an IC50 of 31.1 +/- 1.8 mu M compared to indomethacin (IC50 = 150.0 +/- 16.0 mu M) as the positive control.
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