Design and Synthesis of Novel Helix Mimetics Based on the Covalent H-Bond Replacement and Amide Surrogate

A novel hydrogen bond surrogate-based (HBS) alpha-helix mimetic was designed by the combination of covalent H-bond replacement and the use of an ether linkage to substitute an amide bond within a short peptide sequence. The new helix template could be placed in position other than the N-terminus of a short peptide, and the CD studies demonstrate that the template adopts stable conformations in aqueous buffer at exceptionally high temperatures.

Automated summary

A novel hydrogen bond surrogate-based alpha-helix mimetic was designed using covalent H-bond replacement and an ether linkage to substitute an amide bond. CD studies showed that the mimetic maintained stable conformations in aqueous buffer at high temperatures.