☆ 4.6 Article

Neuropeptides, New Ligands of SARS-CoV-2 Nucleoprotein, a Potential Link between Replication, Inflammation and Neurotransmission

MOLECULES (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Infectious Diseases

Home as the new frontier for the treatment of COVID-19: the case for anti-inflammatory agents

Norberto Perico et al.

Summary: COVID-19 exhibits varying degrees of symptom severity, requiring different levels of care at different stages of the disease. Intervening early with anti-inflammatory drugs, especially NSAIDs, in the outpatient setting could prevent disease progression and long-term complications. Observational studies have shown promising results regarding the use of NSAIDs for early outpatient treatment of COVID-19.

LANCET INFECTIOUS DISEASES (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Selective G protein signaling driven by substance P-neurokinin receptor dynamics

Julian A. Harris et al.

Summary: The neuropeptide substance P activates the neurokinin-1 receptor through interactions deep within the receptor, while interactions between the neuropeptide and the receptor extracellular loops regulate G protein signaling selectivity. This study sheds light on how different stimuli can lead to distinct G protein signaling at the same receptor.

NATURE CHEMICAL BIOLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Dimerization of SARS-CoV-2 nucleocapsid protein affects sensitivity of ELISA based diagnostics of COVID-19

Wajihul Hasan Khan et al.

Summary: This study demonstrates the significant impact of dimerization of the nucleocapsid protein on sensitivity of COVID-19 diagnostic assays. The dimeric form shows higher recognition by specific monoclonal antibodies and exhibits greater stability and antigenicity compared to the monomeric form. Manufacturers should maintain the monomer-dimer composition for accurate and robust diagnostics.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

添加到收藏夹

Article Biochemical Research Methods

ColabFold: making protein folding accessible to all

Milot Mirdita et al.

Summary: ColabFold combines fast homology search and optimized model utilization to offer accelerated prediction of protein structures and complexes, with a processing speed that is 40-60 times faster. It serves as a free and accessible platform for protein folding, capable of predicting close to 1,000 structures per day.

NATURE METHODS (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates

Ibolya Rutkai et al.

Summary: COVID-19 infection can lead to neurological manifestations, and animal models can provide insights into the underlying mechanisms. In this study, neuroinflammation, microhemorrhages, and brain hypoxia were observed in SARS-CoV-2 infected non-human primates, even in those without severe respiratory disease. These findings are important for understanding the neuropathogenesis of SARS-CoV-2 infection and may help explain the neurological symptoms associated with long COVID.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Review Biology

Post-COVID-19 Condition: Where Are We Now?

Paula Boaventura et al.

Summary: COVID-19 is a systemic infection that can cause chronic complications, including fatigue, dyspnea, sleep difficulties, anxiety or depression, and reduced lung capacity. The virus may also affect the thyroid gland, potentially contributing to long-term symptoms.

LIFE-BASEL (2022)

添加到收藏夹

Article Cell Biology

SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery

Justin J. Frere et al.

Summary: This study compared the short- and long-term systemic responses after SARS-CoV-2 and influenza A virus (IAV) infection, and found that SARS-CoV-2 caused more severe and lasting lung and kidney damage compared to IAV. It also uniquely affected the olfactory bulb and olfactory epithelium. Despite viral clearance, the olfactory bulb and epithelium showed sustained transcriptional changes and correlated with behavioral changes, providing insights into the persistent symptoms of COVID-19.

SCIENCE TRANSLATIONAL MEDICINE (2022)

添加到收藏夹

Article Virology

Photodynamic Inactivation of SARS-CoV-2 Infectivity and Antiviral Treatment Effects In Vitro

Svitlana Ziganshyna et al.

Summary: Despite available vaccines, antibodies and antiviral agents, novel treatments and preventive measures are urgently needed to combat the ongoing SARS-CoV-2 pandemic. This study explored the potential of photodynamic inactivation (PDI) using a photosensitizer called THPTS to treat clinical SARS-CoV-2 isolates. The results showed that THPTS-based PDI could effectively reduce viral RNA levels and improve mitochondrial activity. Further testing is needed to determine its efficacy in vivo.

VIRUSES-BASEL (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records

Ellen J. Thompson et al.

Summary: The frequency and risk factors of long COVID in community-based individuals are unclear. A study analyzing data from 10 UK population-based studies and electronic health records found wide variation in the frequency of long COVID between studies, but identified some consistent risk factors.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Correction Multidisciplinary Sciences

An open label randomized clinical trial of Indomethacin for mild and moderate hospitalised Covid-19 patients (Apr, 10.1038/s41598-022-10370-1, 2022)

Rajan Ravichandran et al.

SCIENTIFIC REPORTS (2022)

添加到收藏夹

Editorial Material Biology

Locked in a pro-inflammatory state

Chiu Wang Chau et al.

Summary: Macrophages fail to transition into an anti-inflammatory state after engulfing viable SARS-CoV-2 particles, potentially contributing to damaging immune reactions associated with severe COVID-19.

ELIFE (2022)

添加到收藏夹

Article Biology

Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells

Ana C. G. Salina et al.

Summary: This study reveals that the engulfment of SARS-CoV-2-infected apoptotic cells by macrophages exacerbates inflammatory cytokine production and impairs the ability of macrophages to perform continual efferocytosis. Lung monocytes and macrophages from severe COVID-19 patients also show compromised efferocytic capacity.

ELIFE (2022)

添加到收藏夹

Article Microbiology

Nucleocapsid mutations R203K/G204R increase the infectivity, fitness, and virulence of SARS-CoV-2

Haibo Wu et al.

Summary: The study found that the co-occurring mutations R203K/G204R on the SARS-CoV-2 nucleocapsid protein contribute to the emergence of high-transmissibility variants with replication advantages. These variants show increased infectivity in human lung cells and hamsters, with a positive association observed between increased COVID-19 severity and sample frequency of these mutations.

CELL HOST & MICROBE (2021)

添加到收藏夹

Article Clinical Neurology

Neuropathological explanation of minimal COVID-19 infection rate in newborns, infants and children - a mystery so far. New insight into the role of Substance P

Riffat Mehboob et al.

Summary: COVID-19 has become a global challenge, impacting elderly population significantly while sparing infants and children, possibly due to alterations in neurotransmitters like Substance P. Further research is needed to understand the protective mechanisms in children and the varying infection rates among different age groups worldwide.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2021)

添加到收藏夹

Article Virology

Nonsteroidal Anti-inflammatory Drugs Dampen the Cytokine and Antibody Response to SARS-CoV-2 Infection

Jennifer S. Chen et al.

Summary: Research has shown that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the inflammatory response and antibody production in SARS-CoV-2 infection treatment, without affecting susceptibility to infection or viral replication.

JOURNAL OF VIROLOGY (2021)

添加到收藏夹

Article Clinical Neurology

Proenkephalin Decreases in Cerebrospinal Fluid with Symptom Progression of Huntington's Disease

Valter Niemela et al.

Summary: Identifying molecular changes in Huntington's disease is crucial for therapy development. Mass-spectrometry analysis revealed differences in protein expression between HD patients and controls, with PENK levels potentially serving as a marker for the state of medium spiny neurons in HD.

MOVEMENT DISORDERS (2021)

添加到收藏夹

Article Virology

SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-beta Production

Keli Chen et al.

Summary: The nucleocapsid (N) protein of SARS-CoV-2 plays a crucial role in inhibiting interferon beta production by interacting with the key component RIG-I in the RNA recognition pathway, potentially affecting the host's immune response.

VIRUSES-BASEL (2021)

添加到收藏夹

Article Multidisciplinary Sciences

The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein

Shan Lu et al.

Summary: The SARS-CoV-2 nucleocapsid (N) protein binds viral RNA and undergoes liquid-liquid phase separation driven by its central intrinsically-disordered region, modulated by phosphorylation. Additionally, the N protein interacts with the membrane protein M to form mutually exclusive compartments in a three-component mixture with RNA.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Immunology

Chemokine CCL2 prevents opioid-induced inhibition of nociceptive synaptic transmission in spinal cord dorsal horn

Mario Heles et al.

Summary: The study revealed that elevated levels of CCL2 may severely weaken the opioid-induced inhibition of excitatory synaptic transmission through a microglia activation mechanism, while the delayed enhancement of neurotransmission after mu OR activation is dependent on TRPV1 receptor activation.

JOURNAL OF NEUROINFLAMMATION (2021)

添加到收藏夹

Article Biophysics

1H, 13C and 15N Backbone chemical shift assignments of the n-terminal and central intrinsically disordered domains of SARS-CoV-2 nucleoprotein

Serafima Guseva et al.

Summary: The nucleoprotein (N) from SARS-CoV-2 plays an important role in the viral replication transcription complex and in protecting the viral genome from the host immune system. N is a 419 amino acid multidomain protein with two folded domains and a predicted intrinsically disordered region, for which atomic resolution information is currently lacking.

BIOMOLECULAR NMR ASSIGNMENTS (2021)

添加到收藏夹

Article Immunology

SARS-CoV-2 N Protein Induces Acute Lung Injury in Mice via NF-κB Activation

Jie Xia et al.

Summary: The research indicates that the SARS-CoV-2 nucleocapsid protein (N-protein) appears early in body fluids and directly contributes to lung injury; N-protein may induce acute lung injury by triggering phosphorylation of NF-kappa B pathway.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Virology

Do fever-relieving medicines have anti-COVID activity: an in silico insight

Fahad Hassan Shah et al.

Summary: The study demonstrates that acetaminophen and naproxen have inhibitory activity against SARS-CoV-2 essential proteins, showing anti-inflammatory, antiviral, and immunostimulant properties.

FUTURE VIROLOGY (2021)

添加到收藏夹

Article Medicine, General & Internal

Substance P/Neurokinin-1 Receptor, Trigeminal Ganglion, Latency, and Coronavirus Infection-Is There Any Link?

Riffat Mehboob et al.

Summary: SARS-CoV-2 infection induces inflammation possibly through the release of Substance P in the trigeminal ganglion, which can be treated with neurokinin-1 receptor antagonists and glucocorticoids.

FRONTIERS IN MEDICINE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

DCcov: Repositioning of drugs and drug combinations for SARS-CoV-2 infected lung through constraint-based modeling

Ali Kishk et al.

Summary: The study uses flux balance analysis to analyze human lung cells infected with SARS-CoV-2, in order to reposition metabolic drugs and drug combinations to inhibit virus replication.

ISCIENCE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Antiviral Properties of the NSAID Drug Naproxen Targeting the Nucleoprotein of SARS-CoV-2 Coronavirus

Olivier Terrier et al.

Summary: The study investigates the efficacy of naproxen as an antiviral drug against SARS-CoV-2, finding that it can inhibit viral replication in infected cells and protect respiratory epithelium from damage. Compared to other tested drugs, naproxen combines antiviral and anti-inflammatory properties.

MOLECULES (2021)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication

Yuchen Zhang et al.

Summary: The study demonstrates that SARS-CoV-2 infection alters host cell metabolism to support viral replication, with a clear sensitivity to inhibitors of folate and one-carbon metabolism. Targeted therapy focusing on host metabolism may be a valuable tool in fighting future coronavirus outbreaks.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA

Jasmine Cubuk et al.

Summary: The study reveals that SARS-CoV-2 nucleocapsid (N) protein undergoes liquid-liquid phase separation with RNA, and provides molecular details of N protein through single-molecule spectroscopy with all-atom simulations, showing its multivalent RNA-binding nature and interactions that may drive RNA compaction.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Virology

Direct Activation of Endothelial Cells by SARS-CoV-2 Nucleocapsid Protein Is Blocked by Simvastatin

Yisong Qian et al.

Summary: Evidence suggests that SARS-CoV-2's NP significantly activates human endothelial cells through TLR2/NF-κB and MAPK signaling pathways, with simvastatin identified as a potential inhibitor. This study provides insights on COVID-19-induced vasculopathy and coagulopathy, emphasizing the importance of understanding the mechanistic role of vasculature in these patients.

JOURNAL OF VIROLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Highly accurate protein structure prediction with AlphaFold

John Jumper et al.

Summary: Proteins are essential for life, and accurate prediction of their structures is a crucial research problem. Current experimental methods are time-consuming, highlighting the need for accurate computational approaches to address the gap in structural coverage. Despite recent progress, existing methods fall short of atomic accuracy in protein structure prediction.

NATURE (2021)

添加到收藏夹

Review Oncology

SARS-CoV-2, hemoglobin and protoporphyrin IX: Interactions and perspectives

Lilia Coronato Courrol et al.

Summary: Patients with Covid-19 show decreased hemoglobin levels and increased PpIX levels; Using PpIX fluorescence as a sensor can monitor the presence of SARS-CoV-2 and assess disease severity; Fluorescence spectroscopy can be used as a low-cost, high sensitivity diagnostic technique for Covid-19.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease

Melanie Ricke-Hoch et al.

Summary: The study found that SARS-CoV-2, male sex, old age, and sedentary lifestyle increase PGE2 levels, which may reduce early antiviral defenses and promote severe disease courses and multiple infections.

PLOS ONE (2021)

添加到收藏夹

Review Virology

The SARS-CoV-2 Nucleocapsid Protein and Its Role in Viral Structure, Biological Functions, and a Potential Target for Drug or Vaccine Mitigation

Zhihua Bai et al.

Summary: The N protein of SARS-CoV-2 shares high homology with other coronavirus N proteins, indicating its potential significance as a drug target or vaccine candidate. Further research is needed to explore the functional aspects of this protein in controlling the spread of the virus.

VIRUSES-BASEL (2021)

添加到收藏夹

Article Cell Biology

Long-term SARS-CoV-2-specific immune and inflammatory responses in individuals recovering from COVID-19 with and without post-acute symptoms

Michael J. Peluso et al.

Summary: In this study, 70 individuals with PCR-confirmed SARS-CoV-2 infection were longitudinally observed for T cell responses, inflammation markers, antibody levels, and neutralization capacity. The study found that T cell responses remain stable for up to 9 months and that CD4(+) T cell responses in the early stage correlate with the severity of infection. Pre-existing lung disease is independently associated with higher long-term CD8(+) T cell responses, and individuals with PASC showed a more rapid decline in specific CD8(+) T cell responses.

CELL REPORTS (2021)

添加到收藏夹

Article Microbiology

Recombinant SARS-CoV-2 Nucleocapsid Protein: Expression, Purification, and Its Biochemical Characterization and Utility in Serological Assay Development to Assess Immunological Responses to SARS-CoV-2 Infection

Da Di et al.

Summary: This study demonstrated the expression and purification of two forms of SARS-CoV-2 nucleocapsid protein N for the development of serological assays to detect SARS-CoV-2 infection, showcasing that the RNA-free form of N exhibits slightly higher sensitivity in specific detection. Furthermore, it was shown that N preferentially binds ssRNA in a sequence-independent manner and that both NTD and CTD of N contribute to RNA-binding activity.

PATHOGENS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

Yan Gao et al.

SCIENCE (2020)

添加到收藏夹

Letter Biology

SARS-CoV-2-encoded nucleocapsid protein acts as a viral suppressor of RNA interference in cells

Jingfang Mu et al.

SCIENCE CHINA-LIFE SCIENCES (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites

Sisi Kang et al.

ACTA PHARMACEUTICA SINICA B (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Biochemical characterization of SARS-CoV-2 nucleocapsid protein

Weihong Zeng et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Architecture and self-assembly of theSARS-CoV-2 nucleocapsid protein

Qiaozhen Ye et al.

PROTEIN SCIENCE (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Food-Derived Opioid Peptides in Human Health: A Review

Akanksha Tyagi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography

Steffen Klein et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Neurosciences

Cervical sympathectomy modulates the neurogenic inflammatory neuropeptides following experimental subarachnoid hemorrhage in rats

Yasar Dagistan et al.

BRAIN RESEARCH (2019)

添加到收藏夹

Article Biochemical Research Methods

MMseqs2 desktop and local web server app for fast, interactive sequence searches

Milot Mirdita et al.

BIOINFORMATICS (2019)

添加到收藏夹

Review Neurosciences

Endogenous and Exogenous Opioids in Pain

Gregory Corder et al.

ANNUAL REVIEW OF NEUROSCIENCE, VOL 41 (2018)

添加到收藏夹

Article Chemistry, Medicinal

From Naproxen Repurposing to Naproxen Analogues and Their Antiviral Activity against Influenza A Virus

Sebastien Dilly et al.

JOURNAL OF MEDICINAL CHEMISTRY (2018)

添加到收藏夹

Article Critical Care Medicine

Serum substance P levels are associated with severity and mortality in patients with severe traumatic brain injury

Leonardo Lorente et al.

CRITICAL CARE (2015)

添加到收藏夹

Article Neurosciences

Substance P Exacerbates Dopaminergic Neurodegeneration through Neurokinin-1 Receptor-Independent Activation of Microglial NADPH Oxidase

Qingshan Wang et al.

JOURNAL OF NEUROSCIENCE (2014)

添加到收藏夹

Article Microbiology

Structure-Based Discovery of the Novel Antiviral Properties of Naproxen against the Nucleoprotein of Influenza A Virus

Nathalie Lejal et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Influence of Physiologic Folate Deficiency on Human Papillomavirus Type 16 (HPV16)-harboring Human Keratinocytes in Vitro and in Vivo

Suhong Xiao et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

添加到收藏夹

Article Respiratory System

Plasma Substance P Levels in Patients with Persistent Cough

Kojiro Otsuka et al.

RESPIRATION (2011)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Mechanistic insights into folic acid-dependent vascular protection: Dihydrofolate reductase (DHFR)-mediated reduction in oxidant stress in endothelial cells and angiotensin II-infused mice: A novel HPLC-based fluorescent assay for DHFR activity

Ling Gao et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2009)

添加到收藏夹

Article Endocrinology & Metabolism

Attenuation of angiotensin II signaling recouples eNOS and inhibits nonendothelial NOX activity in diabetic mice

Jeong-Ho Oak et al.

DIABETES (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

Nucleocapsid protein of SARS-CoV activates the expression of cyclooxygenase-2 by binding directly to regulatory elements for nuclear factor-kappa B and CCAAT/enhancer binding protein

Xiaohong Yan et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2006)

添加到收藏夹

Article Immunology

Immune response to influenza vaccine in healthy adults and the elderly: association with nutritional status

M Hara et al.

VACCINE (2005)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.