Synthesis, Chiral Resolution and Enantiomers Absolute Configuration of 4-Nitropropranolol and 7-Nitropropranolol

Article Andrology

6-nitrodopamine is a major endogenous modulator of human vas deferens contractility

Jose Britto-Junior et al.

Summary: 6-nitrodopamine (6-ND) is the major catecholamine released from the human vas deferens and its release is inhibited by nitric oxide (NO) inhibition. It plays a pivotal role in the contractility of the vas deferens and is selectively antagonized by tricyclic antidepressants and alpha(1)-adrenergic receptor antagonists.

ANDROLOGY (2022)

添加到收藏夹

Article Medicine, Research & Experimental

6-NitroDopamine is an endogenous modulator of rat heart chronotropism

Jose Britto-Junior et al.

Summary: The study reveals that 6-nitrodopamine (6-ND) is a major modulator of heart rate in rats, and its release is antagonized by certain drugs. The reduction in heart rate caused by beta 1-blockers is due to selective blockade of the 6-ND receptor.

LIFE SCIENCES (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

6-Nitrodopamine is an endogenous mediator of rat isolated epididymal vas deferens contractions induced by electric-field stimulation

Jose Britto-Junior et al.

Summary: 6-ND is released from rat isolated vas deferens, and its effect on tissue contractility is modulated by various pharmacological agents. SCH-23390 causes a leftward shift in the concentration-response curve to 6-ND, while haloperidol and sonepiprazole induce rightward shifts in dopamine concentration-response curves without affecting 6-ND responses. Tricyclic compounds like desipramine, clomipramine, amitriptyline, cyclobenzaprine, and carbamazepine act as selective 6-ND receptor antagonists.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

添加到收藏夹

Article Biochemical Research Methods

Quantification of 6-nitrodopamine in Krebs-Henseleit's solution by LC-MS/MS for the assessment of its basal release from Chelonoidis carbonaria aortae in vitro

Rafael Campos et al.

Summary: This study describes the development and validation of a method for quantification of 6-nitrodopamine in Krebs-Henseleit's solution using LC-MS/MS technology. The results indicate that tortoise aortae display a basal endothelium-derived 6-nitrodopamine release, with mean concentrations of 0.44 +/- 0.06 ng/mL and 0.18 +/- 0.05 ng/mL for endothelium-intact and denuded aortae, respectively.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2021)

添加到收藏夹

Article Medicine, Research & Experimental

6-Nitrodopamine is released by human umbilical cord vessels and modulates vascular reactivity

Jose Britto-Junior et al.

Summary: This study revealed that 6-nitrodopamine (6-ND) is released by human umbilical cord vessels (HUCV) and acts as a selective dopamine D2-receptor antagonist in this tissue. This represents a novel mechanism by which NO may modulate vascular reactivity independently of cGMP production.

LIFE SCIENCES (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary