4.6 Article

Molecular Mechanisms of Aggregation of Canine SOD1 E40K Amyloidogenic Mutant Protein

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Novel oxindole compounds inhibit the aggregation of amyloidogenic proteins associated with neurodegenerative diseases

Shintaro Kimura et al.

Summary: In neurodegenerative disorders, the aggregation of amyloidogenic proteins plays a crucial role in disease progression. Several novel compounds have been found to effectively inhibit aggregate formation of mutant superoxide dismutase 1 (cSOD1 E40K) in dogs and prion protein (hPrP) in humans, suggesting their potential as therapeutic candidates for amyloidogenic neurodegenerative disorders.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2022)

Review Cell Biology

Gene Therapy in Amyotrophic Lateral Sclerosis

Ton Fang et al.

Summary: Over 50 genes have been identified as either cause or modifier in ALS and ALS/FTD spectrum disease, with significant global efforts made to reveal biological pathways underlying the pathogenesis of these gene mutations. Various gene therapies targeting etiologic genes have been investigated and promising results have led to the application of some strategies into ALS clinical trials.
Article Veterinary Sciences

The Long-Term Clinical Course of Canine Degenerative Myelopathy and Therapeutic Potential of Curcumin

Yui Kobatake et al.

Summary: This study investigated the long-term clinical course of canine degenerative myelopathy, finding that urinary incontinence and respiratory disorders were common symptoms, while some dogs exhibited signs of brainstem dysfunction in the terminal stage. The therapeutic effect of curcumin in slowing the progression of the disease was also highlighted.

VETERINARY SCIENCES (2021)

Article Biochemistry & Molecular Biology

Species-specific consequences of an E40K missense mutation in superoxide dismutase 1 (SOD1)

Alexandra C. E. Draper et al.

FASEB JOURNAL (2020)

Article Veterinary Sciences

Changes in respiratory function in Pembroke Welsh Corgi dogs with degenerative myelopathy

Kanae Oyake et al.

JOURNAL OF VETERINARY MEDICAL SCIENCE (2016)

Article Veterinary Sciences

Breed Distribution of SOD1 Alleles Previously Associated with Canine Degenerative Myelopathy

R. Zeng et al.

JOURNAL OF VETERINARY INTERNAL MEDICINE (2014)

Article Veterinary Sciences

Degenerative Myelopathy in a Bernese Mountain Dog with a Novel SOD1 Missense Mutation

F.A. Wininger et al.

JOURNAL OF VETERINARY INTERNAL MEDICINE (2011)

Article Medicine, General & Internal

Amyotrophic lateral sclerosis

Matthew C. Kiernan et al.

LANCET (2011)

Review Clinical Neurology

Clinical genetics of amyotrophic lateral sclerosis: what do we really know?

Peter M. Andersen et al.

NATURE REVIEWS NEUROLOGY (2011)

Article Veterinary Sciences

Canine Degenerative Myelopathy

Joan R. Coates et al.

VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE (2010)

Review Genetics & Heredity

Genetics of motor neuron disorders: new insights into pathogenic mechanisms

Patrick A. Dion et al.

NATURE REVIEWS GENETICS (2009)

Article Multidisciplinary Sciences

Structural and dynamic aspects related to oligomerization of apo SOD1 and its mutants

Lucia Banci et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis

Tomoyuki Awano et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Neurosciences

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS

Bradley J. Turner et al.

PROGRESS IN NEUROBIOLOGY (2008)

Article Multidisciplinary Sciences

Common dynamical signatures of familial amyotrophic lateral sclerosis-associated structurally diverse Cu, Zn superoxide dismutase mutants

SD Khare et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

Relative influence of hydrophobicity and net charge in the aggregation of two homologous proteins

M Calamai et al.

BIOCHEMISTRY (2003)

Article Multidisciplinary Sciences

Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases

F Chiti et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Multidisciplinary Sciences

Natural β-sheet proteins use negative design to avoid edge-to-edge aggregation

JS Richardson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)