Modulation of the gut microbiota engages antigen cross-presentation to enhance antitumor effects of CAR T cell immunotherapy

Article Immunology

Suppression of local type I interferon by gut microbiota-derived butyrate impairs antitumor effects of ionizing radiation

Kaiting Yang et al.

Summary: The gut microbiota influences tumor control following ionizing radiation by altering the abundance of butyrate-producing bacteria, which can enhance tumor sensitivity to radiation.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Review Oncology

Radiotherapy and the gut microbiome: facts and fiction

Jing Liu et al.

Summary: The gut microbiome has a bidirectional relationship with radiotherapy, potentially influencing treatment efficacy by modulating the tumor microenvironment. Personalized approaches such as probiotics, prebiotics, or fecal microbial transplantation may optimize the gut microbiome response to treatment. Further research is needed to explore the mechanisms of radiation on the microbiome and the application of multi-omic methods in investigating functional changes.

RADIATION ONCOLOGY (2021)

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Article Multidisciplinary Sciences

Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients

Erez N. Baruch et al.

Summary: This study conducted a phase 1 clinical trial and found that FMT treatment in patients with anti-PD-1-refractory metastatic melanoma, along with reinduction of anti-PD-1 immunotherapy, resulted in clinical responses in some patients. This suggests that modulating the gut microbiota could be a promising approach in cancer treatment.

SCIENCE (2021)

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Review Cell & Tissue Engineering

CAR T cells in solid tumors: challenges and opportunities

Faroogh Marofi et al.

Summary: CAR T cells have shown significant advancements in treating blood disorders, but face challenges in solid tumor therapy due to issues with recognition, trafficking, and survival within the tumor. Efforts to overcome these challenges, including addressing the immunosuppressive tumor microenvironment, show promise in reducing T cell exhaustion and improving therapeutic outcomes in non-hematologic malignancies.

STEM CELL RESEARCH & THERAPY (2021)

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Letter Medicine, General & Internal

Five-Year Outcomes for Refractory B-Cell Lymphomas with CAR T-Cell Therapy

Elise A. Chong et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Multidisciplinary Sciences

Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients

Diwakar Davar et al.

Summary: The study demonstrated that fecal microbiota transplantation combined with anti-PD-1 therapy can overcome resistance to anti-PD-1 in a subset of PD-1 refractory melanoma patients, leading to clinical benefits. This approach induced changes in the gut microbiome and reprogrammed the tumor microenvironment, ultimately enhancing the efficacy of anti-PD-1 treatment.

SCIENCE (2021)

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Article Oncology

Combination of vasculature targeting, hypofractionated radiotherapy, and immune checkpoint inhibitor elicits potent antitumor immune response and blocks tumor progression

Stefano Pierini et al.

Summary: The combination of RT with heterologous TEM1 vaccination reduces the progression of irradiated and distant tumors. RT increases MHCI expression on endothelial cells, enhancing immune recognition and causing severe vascular damage. Heterologous TEM1 vaccine and RT boost TAA cross-priming and augment PD-1/PD-L1 signaling within tumors.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Review Immunology

Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids

Chang H. Kim

Summary: Dietary fiber metabolites, particularly short-chain fatty acids, play crucial roles in maintaining immune system balance, regulating host metabolism, intestinal functions, and immunity system.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Review Cell Biology

The Functional and Mechanistic Roles of Immunoproteasome Subunits in Cancer

Satyendra Chandra Tripathi et al.

Summary: Cell-mediated immunity is driven by antigenic peptide presentation on major histocompatibility complex (MHC) molecules. Immunoproteasomes, with inducible activity by inflammatory stimuli, play central roles in cancer, autoimmunity, and inflammation by altering the catalytic activity of the proteasome.Understanding the roles of immunoproteasome in different cancers offers insights into developing targeted therapies.

CELLS (2021)

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Review Oncology

CAR-T cell therapy: current limitations and potential strategies

Robert C. Sterner et al.

Summary: CAR-T cell therapy has shown remarkable clinical responses in certain subsets of leukemia or lymphoma, but faces challenges in solid tumors and hematological malignancies. Innovative strategies and approaches are necessary to overcome these challenges and improve the efficacy of CAR-T cells.

BLOOD CANCER JOURNAL (2021)

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Article Biochemistry & Molecular Biology

Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade

Miles C. Andrews et al.

Summary: The study showed that tumor-associated immune and genomic biomarkers of response to combined immune checkpoint blockade (CICB) in melanoma patients were similar to those of monotherapy, while toxicity from CICB was associated with a more diverse peripheral T-cell repertoire. Additionally, analysis of gut microbiota revealed a higher abundance of Bacteroides intestinalis in patients experiencing toxicity, along with an upregulation of the inflammatory factor IL-1 beta in colitis samples.

NATURE MEDICINE (2021)

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Article Multidisciplinary Sciences

Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer

Maik Luu et al.

Summary: Short-chain fatty acids pentanoate and butyrate can enhance the anti-tumor activity of immune cells through metabolic and epigenetic reprogramming, making them potential therapeutic agents in cancer immunotherapy.

NATURE COMMUNICATIONS (2021)

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Article Medicine, Research & Experimental

Gut microbiota modulate dendritic cell antigen presentation and radiotherapy-induced antitumor immune response

Mireia Uribe-Herranz et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Oncology

Optimizing Chimeric Antigen Receptor T-Cell Therapy for Adults With Acute Lymphoblastic Leukemia

Noelle Frey et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

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Article Medicine, General & Internal

KTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma

Michael Wang et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Cell Biology

Intestinal microbiota: a new force in cancer immunotherapy

Zhujiang Dai et al.

CELL COMMUNICATION AND SIGNALING (2020)

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Article Medicine, General & Internal

Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study

Jeremy S. Abramson et al.

LANCET (2020)

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Article Multidisciplinary Sciences

Health and disease markers correlate with gut microbiome composition across thousands of people

Ohad Manor et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

Deciphering functional redundancy in the human microbiome

Liang Tian et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

CD103+ cDC1 and endogenous CD8+ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function

Nicholas F. Kuhn et al.

NATURE COMMUNICATIONS (2020)

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Review Immunology

A guide to cancer immunotherapy: from T cell basic science to clinical practice

Alex D. Waldman et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Review Immunology

Host-microbiota interactions in inflammatory bowel disease

Roberta Caruso et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Article Multidisciplinary Sciences

The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes

Maik Luu et al.

NATURE COMMUNICATIONS (2019)

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Article Oncology

Gut microbiome and cancer immunotherapy

Weina Li et al.

CANCER LETTERS (2019)

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Review Oncology

Dendritic Cells and Cancer: From Biology to Therapeutic Intervention

Ben Wylie et al.

CANCERS (2019)

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Article Genetics & Heredity

pathfindR: An R Package for Comprehensive Identification of Enriched Pathways in Omics Data Through Active Subnetworks

Ege Ulgen et al.

FRONTIERS IN GENETICS (2019)

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Article Medicine, General & Internal

Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Stephen J. Schuster et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Review Immunology

The Intriguing History of Cancer Immunotherapy

Paula Dobosz et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Multidisciplinary Sciences

Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients

V. Gopalakrishnan et al.

SCIENCE (2018)

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Article Multidisciplinary Sciences

Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors

Bertrand Routy et al.

SCIENCE (2018)

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Article Medicine, General & Internal

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

S. L. Maude et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Review Immunology

Current Concepts of Antigen Cross-Presentation

Maria Embgenbroich et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Meeting Abstract Hematology

Radiation Therapy As a Bridging Strategy for Refractory Diffuse Large B Cell Lymphoma Patients Awaiting CAR T Manufacturing of Axicabtagene Ciloleucel

Michael D. Jain et al.

BLOOD (2018)

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Article Medicine, Research & Experimental

Gut microbiota modulates adoptive cell therapy via CD8α dendritic cells and IL-12

Mireia Uribe-Herranz et al.

JCI INSIGHT (2018)

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Article Medicine, General & Internal

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

S. S. Neelapu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Article Multidisciplinary Sciences

Butyrate and propionate inhibit antigen-specific CD8+ T cell activation by suppressing IL-12 production by antigen-presenting cells

Claudia Nastasi et al.

SCIENTIFIC REPORTS (2017)

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Article Cell Biology

Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18

Biliang Hu et al.

CELL REPORTS (2017)

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Article Medicine, Research & Experimental

A simple, clinically relevant therapeutic vaccine shows long-term protection in an aggressive, delayed-treatment B lymphoma model

Pallab Pradhan et al.

JCI INSIGHT (2017)

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Review Immunology

Dysbiosis and the immune system

Maayan Levy et al.

NATURE REVIEWS IMMUNOLOGY (2017)

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Review Immunology

Transcriptional Control of Dendritic Cell Development

Theresa L. Murphy et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 34 (2016)

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Article Oncology

How Do Cytotoxic Lymphocytes Kill Cancer Cells?

Luis Martinez-Lostao et al.

CLINICAL CANCER RESEARCH (2015)

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Article Immunology

Batf3 maintains autoactivation of Irf8 for commitment of a CD8α+ conventional DC clonogenic progenitor

Gary E. Grajales-Reyes et al.

NATURE IMMUNOLOGY (2015)

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Article Hematology

Selective and efficient generation of functional Batf3-dependent CD103+ dendritic cells from mouse bone marrow

Christian Thomas Mayer et al.

BLOOD (2014)

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Review Immunology

Antigen-specific T-cell activation independently of the MHC: chimeric antigen receptor-redirected T cells

Markus Chmielewski et al.

FRONTIERS IN IMMUNOLOGY (2013)

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Article Infectious Diseases

Systemic absorption of oral vancomycin in patients with Clostridium difficile infection

Sriharsha Rao et al.

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES (2011)

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Article Cell Biology

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

Michael Kalos et al.

SCIENCE TRANSLATIONAL MEDICINE (2011)

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Review Immunology

MHC class I antigen presentation: learning from viral evasion strategies

Ted H. Hansen et al.

NATURE REVIEWS IMMUNOLOGY (2009)

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Article Microbiology

Biochemical differentiation and comparison of Desulfovibrio species and other phenotypically similar genera

YA Warren et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2005)

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Article Cell Biology

Role of TAP-1 and/or TAP-2 antigen presentation defects in tumorigenicity of mouse melanoma

S Agrawal et al.

CELLULAR IMMUNOLOGY (2004)

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Article Immunology

Critical components of a DNA fusion vaccine able to induce protective cytotoxic T cells against a single epitope of a tumor antigen

J Rice et al.

JOURNAL OF IMMUNOLOGY (2002)

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Modulation of the gut microbiota engages antigen cross-presentation to enhance antitumor effects of CAR T cell immunotherapy

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