4.3 Article

Postnatal developmental expression and localization of apelin and apelin receptor protein in the ovary and uterus of mice

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Apelin and Apelin Receptor in Follicular Granulosa Cells of Buffalo Ovaries: Expression and Regulation of Steroidogenesis

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Summary: This study investigated the expression levels of APLN/APJ in buffalo ovarian granulose cells (GCs) and the effects of IGF1 and FSH on APLN/APJ expression. The results showed that APLN expression was highest in large-sized GCs, while APJ expression increased with follicle enlargement. IGF1 and FSH increased the expression of APLN and FSH, and IGF1 also increased the expression of APJ. Both isoforms of APLN increased the secretion of E2 and P4, potentially through upregulation of CYP19A1 and StAR expression. In conclusion, APLN may play a crucial role in steroidogenesis and follicular development in buffalo ovarian GCs.

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