期刊
MOLECULAR REPRODUCTION AND DEVELOPMENT
卷 90, 期 1, 页码 42-52出版社
WILEY
DOI: 10.1002/mrd.23657
关键词
apelin; apelin receptor; mice; ovary; postnatal; uterus
Postnatal expression and localization of apelin and APJ were investigated in the ovary and uterus of mice. Uterine APJ levels were elevated at postnatal day (PND) 14 and PND 65, while ovarian APJ levels were elevated at PND 7, PND 14, and PND 65. Apelin expression in both ovary and uterus showed intense staining at PND 65 and PND 14. The results indicated that apelin and APJ are developmentally regulated in the ovary and uterus and have specific physiological roles in different compartments.
Postnatal ovarian and uterine development is crucial to accomplished female fertility. Thus, the investigations of factors that present in pre-pubertal stages are important as it might be responsible for the regulation of ovarian and uterine function. Apelin, an adipokine and its receptor (APJ) are present in female reproductive organs. However, no study has reported its postnatal expression in uterus and ovary. Thus, we investigated the postnatal developmental changes in expression and localization of apelin and APJ in the ovary and uterus of mice. Postnatal ovary and uterus were collected from postnatal day (PND) 1, 7, 14, 21, 42, 65 and performed western blot analysis and immunohistochemistry. Uterine APJ is elevated in PND14 and PND65, whereas, ovarian APJ elevated in PND7, PND14, and PND65. Apelin expression in both ovary and uterus showed intense staining at PND65 and PND14. Our results showed that apelin and APJ abundance was lower at PND21 in uterus and ovary. In conclusion, apelin and APJ are developmentally regulated in the ovary and uterus, and its localization in the different compartments of ovary and uterus suggest its distribution specific physiological role in the uterus and ovary.
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