4.6 Article

Molecular Hydrogen: an Emerging Therapeutic Medical Gas for Brain Disorders

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Neurosciences

Microglia contribute to the propagation of Aβ into unaffected brain tissue

Paolo d'Errico et al.

Summary: This study demonstrates that Aβ can enter and deposit within wild-type grafts via microglia, identifying microglia as carriers of Aβ deposition into previously unaffected brain tissue, thus supporting a previously unexplored mechanism of Aβ propagation.

NATURE NEUROSCIENCE (2022)

Article Cell Biology

Hydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer's disease through reducing neuroinflammation and modulating intestinal microbiota

Yi-Tong Lin et al.

Summary: This study found that hydrogen-rich water can effectively treat 3xTg Alzheimer's disease mice by preventing synaptic loss and neuronal death, inhibiting senile plaques and neurofibrillary tangles, improving brain energy metabolism disorders and intestinal flora imbalances, and reducing inflammatory reactions.

NEURAL REGENERATION RESEARCH (2022)

Article Medicine, Research & Experimental

Hydrogen-rich saline alleviates early brain injury through inhibition of necroptosis and neuroinflammation via the ROS/HO-1 signaling pathway after traumatic brain injury

Yun Hu et al.

Summary: Hydrogen-rich saline treatment showed neuroprotective effects by inhibiting neuronal necroptosis and neuroinflammation, improving neurological outcomes in traumatic brain injury (TBI).

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2022)

Article Nutrition & Dietetics

The Potential Role of Gut Microbiota in Alzheimer's Disease: From Diagnosis to Treatment

Angelica Varesi et al.

Summary: The dysregulation of gut microbiota is implicated in various diseases, including Alzheimer's Disease (AD). This article reviews the role of gut microbiota in brain health and disease and presents evidence for its dysregulation in AD patients. It discusses the potential of using dysbiosis as a diagnostic tool and explores the therapeutic interventions using prebiotics, probiotics, fecal microbiota transplantation, and diets in AD.

NUTRIENTS (2022)

Article Medicine, Research & Experimental

Non-invasive photobiomodulation treatment in an Alzheimer Disease-like transgenic rat model

Luodan Yang et al.

Summary: Alzheimer's disease is a common form of dementia in elderly people with no effective treatment available. This study evaluated the therapeutic effect of long-term low-level laser treatment on Alzheimer's disease and its underlying mechanism. The results showed that low-level laser treatment significantly improved cognitive dysfunction and typical pathologies of Alzheimer's disease, and it worked through multiple mechanisms including regulation of glial cells, preservation of mitochondrial dynamics, and suppression of oxidative damage.

THERANOSTICS (2022)

Editorial Material Neurosciences

Microglia-Mediated Aβ Propagation in Alzheimer's Disease

Luoman Yang et al.

NEUROSCIENCE BULLETIN (2022)

Review Pediatrics

Hydrogen and therapeutic gases for neonatal hypoxic-ischemic encephalopathy: potential neuroprotective adjuncts in translational research

Yinmon Htun et al.

Summary: This article summarizes the current research on the use of hydrogen as a neuroprotective agent in the treatment of neurological disorders, especially in the context of hypoxic-ischemic encephalopathy in newborns. Studies have shown that hydrogen has neuroprotective effects in adult diseases, but research in pediatric and neonatal medicine is still limited.

PEDIATRIC RESEARCH (2021)

Review Pharmacology & Pharmacy

Molecular Hydrogen Application in Stroke: Bench to Bedside

Lei Huang et al.

Summary: Stroke is a major global health concern with limited effective treatments. Molecular hydrogen, as a novel medical gas, shows therapeutic potential for neurological diseases, including stroke. Studies have demonstrated neuroprotective effects of molecular hydrogen therapy in stroke patients and models, providing new insights for stroke treatment.

CURRENT PHARMACEUTICAL DESIGN (2021)

Review Clinical Neurology

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

Fangda Leng et al.

Summary: Microglial activation and neuroinflammation play important roles in Alzheimer's disease, affecting disease progression and pathologies. Current research focuses on the interplay between neuroinflammation and amyloid and tau pathologies, with a specific interest in modulating microglia as a therapeutic strategy for AD.

NATURE REVIEWS NEUROLOGY (2021)

Article Multidisciplinary Sciences

Molecular subtyping of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets

Ryan A. Neff et al.

Summary: This study identified three major molecular subtypes of Alzheimer's disease (AD) and specific driver genes through analyzing transcriptomes from multiple brain regions. The research also demonstrated that existing AD mouse models reflect some degree of subtype heterogeneity, possibly explaining the lack of alignment between successful drugs in specific mouse models and generalized human trials across all AD subtypes. Subtyping patients with AD is considered a critical step towards precision medicine for this devastating disease.

SCIENCE ADVANCES (2021)

Review Neurosciences

Activation and Role of Astrocytes in Ischemic Stroke

Xin-Ya Shen et al.

Summary: Ischemic stroke leads to local brain tissue blood supply disorder, with astrocytes playing a crucial role in the response to the injury. Reactive astrocytes, activated after stroke, exhibit protective functions but also potentially harmful effects. Their spatial and temporal expression determines the diverse functions of astrocytes in the context of ischemic stroke's complex cascade reactions.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

Review Physiology

Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis

Yan Tian et al.

Summary: Molecular hydrogen (H-2) has a wide range of biological effects and can be used to treat various acute and chronic inflammatory diseases, including novel coronavirus pneumonia. Its mechanism of action has not been fully revealed. Due to its safety and potential efficacy, H-2 has great potential in clinical applications.

FRONTIERS IN PHYSIOLOGY (2021)

Article Pharmacology & Pharmacy

Xiaoyao Pills Ameliorate Depression-like Behaviors and Oxidative Stress Induced by Olfactory Bulbectomy in Rats via the Activation of the PIK3CA-AKT1-NFE2L2/BDNF Signaling Pathway

Yafei Ji et al.

Summary: Xiaoyao Pills show antidepressant-like effects in the olfactory bulbectomized rat model by alleviating oxidative stress and enhancing neuroprotective effects through the activation of PIK3CA-AKT1-NFE2L2/BDNF signaling pathways.

FRONTIERS IN PHARMACOLOGY (2021)

Review Biochemistry & Molecular Biology

Heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions

Valeria Consoli et al.

Summary: Heme-oxygenase (HO-1) plays a crucial role in maintaining cellular oxidative damage and has implications in cancer research and antioxidant activity.

BIOMOLECULES (2021)

Article Clinical Neurology

High Neutrophil-Lymphocyte Ratio Predicts Post-stroke Cognitive Impairment in Acute Ischemic Stroke Patients

Minwoo Lee et al.

Summary: This study found that systemic inflammation represented by NLR in the acute stage of ischemic stroke is associated with post-stroke cognitive impairment (PSCI) at 3 months after stroke, with high NLR specifically linked to cognitive dysfunction in the memory and visuospatial domains.

FRONTIERS IN NEUROLOGY (2021)

Review Clinical Neurology

The Pathogenesis of Parkinson's Disease: A Complex Interplay Between Astrocytes, Microglia, and T Lymphocytes?

Adina N. MacMahon Copas et al.

Summary: Parkinson's disease is a neurodegenerative disorder characterized by both motor and non-motor symptoms, including neuroinflammation and degeneration of dopaminergic neurons. In addition to the role of glial cells in maintaining CNS homeostasis, recent evidence suggests that peripheral immune cells, particularly T lymphocytes, play a significant role in the pathogenesis of the disease.

FRONTIERS IN NEUROLOGY (2021)

Review Clinical Neurology

Novel Approaches to Prevent Epileptogenesis After Traumatic Brain Injury

Chris G. Dulla et al.

Summary: Traumatic brain injury (TBI) can lead to post-traumatic epilepsy (PTE) which often resists standard anti-seizure drugs. Novel treatment strategies are needed to prevent PTE after TBI, as there are no successful approaches currently available. TBI presents a unique opportunity for intervention to prevent epileptogenesis, with potential for exciting new advances in the field.

NEUROTHERAPEUTICS (2021)

Review Medicine, Research & Experimental

Role of hydrogen in traumatic brain injury: a narrative review

Hong-Wei Hu et al.

Summary: Traumatic brain injury (TBI) is a serious global public health problem, with survivors often facing long-term disabilities that burden society and families. Hydrogen, as a reducing gas, has shown neuroprotective effects in various cerebral diseases, but its efficacy in TBI remains controversial.

MEDICAL GAS RESEARCH (2021)

Article Medicine, Research & Experimental

Effects of prenatal photobiomodulation treatment on neonatal hypoxic ischemia in rat offspring

Luodan Yang et al.

Summary: Prenatal PBM treatment significantly improves neonatal rat survival rate, reduces infarct size, and alleviates cortex and hippocampus-related behavioral deficits caused by HI injury. Additionally, PBM treatment protects mitochondrial function and integrity, and reduces neuroinflammation and oxidative stress induced by HI insult.

THERANOSTICS (2021)

Article Biochemical Research Methods

Photobiomodulation therapy for repeated closed head injury in rats

Baocheng Yang et al.

JOURNAL OF BIOPHOTONICS (2020)

Article Endocrinology & Metabolism

Neurovascular coupling preserved in a chronic mouse model of Alzheimer's disease: Methodology is critical

Paul S. Sharp et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2020)

Review Neurosciences

The Ambiguous Role of Microglia in Aβ Toxicity: Chances for Therapeutic Intervention

Sara Merlo et al.

CURRENT NEUROPHARMACOLOGY (2020)

Article Multidisciplinary Sciences

The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

Anne-Laure Mahul-Mellier et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Systematic impacts of chronic unpredictable mild stress on metabolomics in rats

Chunmei Geng et al.

SCIENTIFIC REPORTS (2020)

Article Biochemistry & Molecular Biology

Hypoxic-Ischemic Encephalopathy and Mitochondrial Dysfunction: Facts, Unknowns, and Challenges

Marianela Rodriguez et al.

ANTIOXIDANTS & REDOX SIGNALING (2020)

Review Neurosciences

Targeting Oxidative Stress and Inflammation to Prevent Ischemia-Reperfusion Injury

Liquan Wu et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2020)

Article Multidisciplinary Sciences

Renoprotective and neuroprotective effects of enteric hydrogen generation from Si-based agent

Yuki Kobayashi et al.

SCIENTIFIC REPORTS (2020)

Review Neurosciences

Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation

Luodan Yang et al.

TRANSLATIONAL NEURODEGENERATION (2020)

Review Biochemistry & Molecular Biology

Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives

Diji Kuriakose et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Neurosciences

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

Hyuk Sung Kwon et al.

TRANSLATIONAL NEURODEGENERATION (2020)

Review Neurosciences

Alzheimer's Disease, Inflammation, and the Role of Antioxidants

Benjamin Sinyor et al.

JOURNAL OF ALZHEIMERS DISEASE REPORTS (2020)

Article Biochemistry & Molecular Biology

Interleukin-1 in cerebrospinal fluid for evaluating the neurological outcome in traumatic brain injury

Yingming Yue et al.

BIOSCIENCE REPORTS (2019)

Article Medicine, Research & Experimental

Chrysin attenuates global cerebral ischemic reperfusion injury via suppression of oxidative stress, inflammation and apoptosis

Iman H. El Khashab et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Review Pharmacology & Pharmacy

Therapeutic Efficacy of Molecular Hydrogen: A New Mechanistic Insight

Toru Ishibashi

CURRENT PHARMACEUTICAL DESIGN (2019)

Review Biochemistry & Molecular Biology

Oxidative Stress: A Key Modulator in Neurodegenerative Diseases

Anju Singh et al.

MOLECULES (2019)

Review Neurosciences

Mechanism and Treatment Related to Oxidative Stress in Neonatal Hypoxic-Ischemic Encephalopathy

Xingping Qin et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)

Article Chemistry, Multidisciplinary

Hydrogen Gas from Inflammation Treatment to Cancer Therapy

Ying Wu et al.

ACS NANO (2019)

Review Clinical Neurology

Hydrogen as a complementary therapy against ischemic stroke: A review of it the evidence

He Li et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2019)

Article Psychology, Developmental

Corticosterone administration targeting a hypo-reactive HPA axis rescues a socially-avoidant phenotype in scarcity-adversity reared rats

Rosemarie E. Perry et al.

DEVELOPMENTAL COGNITIVE NEUROSCIENCE (2019)

Review Medicine, Research & Experimental

Damage to dopaminergic neurons by oxidative stress in Parkinson's disease (Review)

Ji-Dong Guo et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2018)

Editorial Material Endocrinology & Metabolism

Inadequate Production of H2 by Gut Microbiota and Parkinson Disease

Sergej M. Ostojic

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2018)

Review Neurosciences

Effect of Chronic Oxidative Stress on Neuroinflammatory Response Mediated by CD4+T Cells in Neurodegenerative Diseases

Helena Solleiro-Villavicencio et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

Letter Clinical Neurology

Randomized, Double-Blind, Multicenter Trial of Hydrogen Water for Parkinson's Disease

Asako Yoritaka et al.

MOVEMENT DISORDERS (2018)

Review Medicine, Research & Experimental

The role of hydrogen in Alzheimer's disease

Xin Tan et al.

MEDICAL GAS RESEARCH (2018)

Article Multidisciplinary Sciences

Astrocyte-derived interleukin-15 exacerbates ischemic brain injury via propagation of cellular immunity

Minshu Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Biochemistry & Molecular Biology

Role of Antioxidants in Neonatal Hypoxic-Ischemic Brain Injury: New Therapeutic Approaches

Olatz Arteaga et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Neurosciences

Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges

Lancelot J. Millar et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2017)

Article Multidisciplinary Sciences

Molecular hydrogen increases resilience to stress in mice

Qiang Gao et al.

SCIENTIFIC REPORTS (2017)

Review Neurosciences

Oxidative stress in multiple sclerosis: Central and peripheral mode of action

Kim Ohl et al.

EXPERIMENTAL NEUROLOGY (2016)

Review Pharmacology & Pharmacy

c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer's Disease

Ramon Yarza et al.

FRONTIERS IN PHARMACOLOGY (2016)

Article Neurosciences

Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies

Steve Duleh et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2016)

Article Multidisciplinary Sciences

Effects of hydrogen-rich water on depressive-like behavior in mice

Yi Zhang et al.

SCIENTIFIC REPORTS (2016)

Review Medicine, Research & Experimental

Molecular hydrogen: a therapeutic antioxidant and beyond

Lei Huang

MEDICAL GAS RESEARCH (2016)

Review Anatomy & Morphology

Oxidative stress and Parkinson's disease

Javier Blesa et al.

FRONTIERS IN NEUROANATOMY (2015)

Article Clinical Neurology

Gut Microbiota Are Related to Parkinson's Disease and Clinical Phenotype

Filip Scheperjans et al.

MOVEMENT DISORDERS (2015)

Review Biochemistry & Molecular Biology

Protective and toxic roles of dopamine in Parkinson's disease

Juan Segura-Aguilar et al.

JOURNAL OF NEUROCHEMISTRY (2014)

Article Critical Care Medicine

Methylene Blue Is Neuroprotective against Mild Traumatic Brain Injury

Lora Talley Watts et al.

JOURNAL OF NEUROTRAUMA (2014)

Review Neurosciences

Neuromelanin of the Human Substantia Nigra: An Update

Fabio A. Zucca et al.

NEUROTOXICITY RESEARCH (2014)

Article Medicine, General & Internal

Oxidative Stress and Major Depression

Ashutosh Bajpai et al.

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH (2014)

Article Neurosciences

Oxidative Stress and Pathophysiology of Ischemic Stroke: Novel Therapeutic Opportunities

Ramon Rodrigo et al.

CNS & Neurological Disorders-Drug Targets (2013)

Review Biotechnology & Applied Microbiology

Role of Redox Signaling in Neuroinflammation and Neurodegenerative Diseases

Hsi-Lung Hsieh et al.

BIOMED RESEARCH INTERNATIONAL (2013)

Review Neurosciences

The Role of Oxidative Stress in Parkinson's Disease

Vera Dias et al.

JOURNAL OF PARKINSONS DISEASE (2013)

Review Neurosciences

Will the real multiple sclerosis please stand up?

Peter K. Stys et al.

NATURE REVIEWS NEUROSCIENCE (2012)

Review Materials Science, Multidisciplinary

Nanomaterials for renewable hydrogen production, storage and utilization

Samuel S. Mao et al.

PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL (2012)

Article Cardiac & Cardiovascular Systems

H2 Gas Improves Functional Outcome After Cardiac Arrest to an Extent Comparable to Therapeutic Hypothermia in a Rat Model

Kei Hayashida et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2012)

Review Pharmacology & Pharmacy

Altered calcium signaling following traumatic brain injury

John T. Weber

FRONTIERS IN PHARMACOLOGY (2012)

Review Clinical Neurology

Current and emerging therapies in multiple sclerosis: a systematic review

Wanda Castro-Borrero et al.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2012)

Article Clinical Neurology

Oxidative damage in multiple sclerosis lesions

Lukas Haider et al.

Article Clinical Neurology

Impaired neurovascular coupling in ischaemic stroke patients with large or small vessel disease

W. H. Lin et al.

EUROPEAN JOURNAL OF NEUROLOGY (2011)

Article Nursing

Hypoxic Ischemic Encephalopathy: Pathophysiology and Experimental Treatments

Kimberly A. Allen et al.

NEWBORN AND INFANT NURSING REVIEWS (2011)

Article Behavioral Sciences

Moderate treadmill exercise prevents oxidative stress-induced anxiety-like behavior in rats

Samina Salim et al.

BEHAVIOURAL BRAIN RESEARCH (2010)

Review Clinical Neurology

Antioxidant Therapies for Traumatic Brain Injury

Edward D. Hall et al.

NEUROTHERAPEUTICS (2010)

Article Endocrinology & Metabolism

Persistent increase in oxygen consumption and impaired neurovascular coupling after spreading depression in rat neocortex

Henning Piilgaard et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2009)

Article Clinical Neurology

Astrocytes and Ischemic Injury

Takahiro Takano et al.

STROKE (2009)

Article Neurosciences

Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model

Jianmei Cai et al.

NEUROSCIENCE LETTERS (2008)

Article Biochemistry & Molecular Biology

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

Ikuroh Ohsawa et al.

NATURE MEDICINE (2007)

Review Cell Biology

Stressing the role of FoxO proteins in lifespan and disease

Armando van der Horst et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Electrolyzed hydrogen-saturated water for drinking use elicits an antioxidative effect: A feeding test with rats

T Yanagihara et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2005)

Article Neurosciences

Redox regulation of glial inflammatory response to lipopolysaccharide and interferonγ

S Pawate et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2004)

Article Clinical Neurology

Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations

M Müftüoglu et al.

MOVEMENT DISORDERS (2004)

Review Endocrinology & Metabolism

Reactive oxygen radicals in signaling and damage in the ischemic brain

PH Chan

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2001)

Article Immunology

Heme oxygenase-1 in lesions of rat experimental autoimmune encephalomyelitis and neuritis

HJ Schluesener et al.

JOURNAL OF NEUROIMMUNOLOGY (2000)