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Vyacheslav Akimov et al.
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Dirk Mossmann et al.
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Robert A. Saxton et al.
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Manuele Rebsamen et al.
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Stanley Lipkowitz et al.
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Yasemin Sancak et al.
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ANNUAL REVIEW OF BIOCHEMISTRY (2009)
Molecular mechanisms of mTOR-mediated translational control
Xiaoju Max Ma et al.
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Eunjung Kim et al.
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Yasemin Sancak et al.
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S Yogosawa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Function and regulation of Cullin-RING ubiquitin ligases
MD Petroski et al.
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T Cardozo et al.
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K Inoki et al.
GENES & DEVELOPMENT (2003)
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DH Kim et al.
CELL (2002)