KIN17 promotes cell migration and invasion through stimulating the TGF-β/Smad2 pathway in hepatocellular carcinoma

Review Oncology

The Emerging Role of c-Met in Carcinogenesis and Clinical Implications as a Possible Therapeutic Target

Antonio Faiella et al.

Summary: The translation provides an overview of the importance and therapeutic applications of c-MET in tumors. c-MET has potential roles in tumor treatment and may become a new strategy for targeted therapy.

JOURNAL OF ONCOLOGY (2022)

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Review Biochemistry & Molecular Biology

Transforming growth factor-beta (TGF-β) in prostate cancer: A dual function mediator?

Sepideh Mirzaei et al.

Summary: This review discusses the role of TGF-beta signaling in the proliferation, metastasis, and therapy response of prostate cancer cells. It also explores the regulation of TGF-beta signaling and its clinical application.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Cell Biology

Kin17 facilitates thyroid cancer cell proliferation, migration, and invasion by activating p38 MAPK signaling pathway

Qun-Guang Jiang et al.

Summary: Kin17 is significantly upregulated in thyroid cancer, where it functions as an oncogene by activating the p38 MAPK signaling pathway to promote cell proliferation, migration, and invasion, while also affecting the sensitivity of cancer cells to Doxorubicin.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2021)

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Review Biotechnology & Applied Microbiology

TGFB1/INHBA Homodimer/Nodal-SMAD2/3 Signaling Network: A Pivotal Molecular Target in PDAC Treatment

Mai Abdel Mouti et al.

Summary: Pancreatic cancer is a challenging disease, with chemotherapy as the standard treatment that may paradoxically lead to chemoresistance. The crosstalk between pancreatic tumor cells and the surrounding stromal microenvironment plays a crucial role in the development of chemoresistance. The involvement of the TGFB1/INHBA signaling network in regulating key mechanisms related to chemoresistance highlights potential targets for therapeutic strategies.

MOLECULAR THERAPY (2021)

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Review Biochemistry & Molecular Biology

The Epithelial-to-Mesenchymal Transition (EMT) in the Development and Metastasis of Malignant Pleural Mesothelioma

Valeria Ramundo et al.

Summary: This review aims to describe how EMT is involved in driving the development and invasiveness of MPM, in an attempt to open new scenarios useful in the identification of predictive markers and improve the pharmacological approach against this aggressive cancer.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Cell Biology

Identification of prognostic biomarkers associated with the occurrence of portal vein tumor thrombus in hepatocellular carcinoma

Tong Lin et al.

Summary: This study identified 12 commonly down-expressed DEGs in PVTT tissues, with up-regulation associated with favorable outcomes in HCC patients. Genetic alterations and DNA methylation of DEGs were frequent and correlated with patient prognosis. DEGs and co-expressive genes participated in ECM organization and focal adhesion biological processes.

AGING-US (2021)

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Review Oncology

Bone Morphogenic Protein Signaling and Melanoma

Piotr Kraj

Summary: Malignant melanoma is a deadly form of skin cancer with low survival rates for metastatic patients. The phenotypic plasticity of melanoma cells allows for rapid development of invasive properties and metastatic tumors, primarily caused by the transition from mature melanocytes to less differentiated progenitor cells due to accumulated mutations targeting signaling pathways. Understanding the role of signaling pathways like TGF-beta and BMPs is crucial for controlling EMT processes and achieving clinical benefits for melanoma patients.

CURRENT TREATMENT OPTIONS IN ONCOLOGY (2021)

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Review Oncology

Wnt/β-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasis on Molecular Pathways

Mahshid Deldar Abad Paskeh et al.

Summary: This review discusses the role of Wnt signaling in hepatocellular carcinoma (HCC), including its promotion of HCC progression, impact on therapy response, and regulation of drug resistance and immune resistance mechanisms. Research shows that beta-catenin signaling in HCC cells can enhance cancer stem cell features, promote growth, and inhibit apoptosis, thus accelerating cancer development.

JOURNAL OF HEPATOCELLULAR CARCINOMA (2021)

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Article Oncology

KIN17 promotes tumor metastasis by activating EMT signaling in luminal-A breast cancer

Qiyuan Huang et al.

Summary: The study found that KIN17 expression was associated with poor overall survival in breast cancer patients, especially in Luminal-A type. Knockdown of KIN17 inhibited migration and invasion of breast cancer cells, while overexpression of KIN17 promoted cell migration and invasion.

THORACIC CANCER (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Gadoxetate-enhanced MRI Features of Proliferative Hepatocellular Carcinoma Are Prognostic after Surgery

Hyo-Jin Kang et al.

Summary: This study evaluated the gadoxetate-enhanced MRI findings and prognostic significance of the proliferative class of hepatocellular carcinoma (HCC) after surgery. The proliferative class was associated with poor overall survival, increased rates of intrahepatic and extrahepatic metastasis, and specific predictive factors such as rim arterial phase hyperenhancement on MRI and high serum alpha-fetoprotein levels.

RADIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Interactome Analysis of KIN (Kin17) Shows New Functions of This Protein

Vanessa Pinatto Gaspar et al.

Summary: KIN protein is overexpressed in cancerous cell lines and is considered a possible cancer biomarker. It is associated with RNA processing and may be a moonlight protein.

CURRENT ISSUES IN MOLECULAR BIOLOGY (2021)

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Article Oncology