4.6 Article

UHRF1 plays an oncogenic role in small cell lung cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

USP21 regulates Hippo signaling to promote radioresistance by deubiquitinating FOXM1 in cervical cancer

Zhengliang Li et al.

Summary: USP21 contributes to radio-resistance in cervical cancer cells through the FOXM1/Hippo signaling pathway, suggesting its potential as a target for radiosensitizers in radiotherapy.

HUMAN CELL (2022)

Article Gastroenterology & Hepatology

Dual Targeting of G9a and DNA Methyltransferase-1 for the Treatment of Experimental Cholangiocarcinoma

Leticia Colyn et al.

Summary: The study suggests that dual targeting of G9a and DNMT1 with epigenetic small molecule inhibitors such as CM272 may be a potential strategy to treat cholangiocarcinoma, inhibiting the growth of CCA cells and synergizing with other drugs, showing significant antagonistic effects on CCA tumor progression.

HEPATOLOGY (2021)

Editorial Material Oncology

Epigenetic Modifier UHRF1 May Be a Potential Target in Malignant Pleural Mesothelioma

Anne-Marie Baird et al.

JOURNAL OF THORACIC ONCOLOGY (2021)

Article Medicine, General & Internal

Small-cell lung cancer

Charles M. Rudin et al.

Summary: Small-cell lung cancer is a type of lung cancer characterized by high proliferative rate, early metastasis, and poor prognosis, strongly associated with tobacco carcinogens. Most patients are diagnosed with metastatic disease, with only a small fraction having potentially curative earlier-stage disease. Genomic profiling reveals extensive chromosomal rearrangements and high mutation burden in SCLC, often involving inactivation of TP53 and RB1 tumor suppressor genes.

NATURE REVIEWS DISEASE PRIMERS (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Cell Biology

Whole-exome sequencing reveals germline-mutated small cell lung cancer subtype with favorable response to DNA repair-targeted therapies

Camille Tlemsani et al.

Summary: This study identified deleterious variants in cancer-predisposition genes in a significant portion of SCLC patients, impacting medical management and family member testing. Germline genotype was associated with family history of cancer, as well as recurrence-free survival after platinum-based chemotherapy. The findings suggest potential for targeted therapies based on inherited predisposition in SCLC patients.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Article Multidisciplinary Sciences

Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ

Giulia Della Chiara et al.

Summary: This study epigenetically characterized human colorectal cancer and identified a tumor-specific deregulated enhancerome that is intrinsic to cancer cells. The research also revealed the key role of the transcriptional coactivators YAP/TAZ in regulating the gained enhancers in CRC and demonstrated their potential therapeutic implications.

NATURE COMMUNICATIONS (2021)

Article Cell Biology

Serine Metabolism Regulates YAP Activity Through USP7 in Colon Cancer

Xiaoya Zhao et al.

Summary: Metabolic reprogramming, specifically serine metabolism through USP7-regulated YAP activity, plays a crucial role in colon cancer growth. The study suggests VP as a potential new treatment for colon cancer by targeting YAP activity and serine metabolism.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

The multi-functionality of UHRF1: epigenome maintenance and preservation of genome integrity

Monica Mancini et al.

Summary: During S phase, the cooperation between macromolecular complexes regulating DNA synthesis, epigenetic information maintenance, and DNA repair benefits cells by rapidly detecting and initiating DNA damage response. UHRF1, a fundamental epigenetic regulator, plays a crucial role in DNA damage repair, sensing interstrand crosslinks, and determining the switch towards homologous recombination in double-strand break repair. Its functions are finely regulated by specific post-translational modifications, with the SRA domain binding to damaged DNA and the RING domain facilitating repair.

NUCLEIC ACIDS RESEARCH (2021)

Article Multidisciplinary Sciences

YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma

Hirofumi Omori et al.

SCIENCE ADVANCES (2020)

Review Biotechnology & Applied Microbiology

Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine

Anwesha Dey et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Article Multidisciplinary Sciences

Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie

Xiaohan Sun et al.

NATURE COMMUNICATIONS (2019)

Review Medicine, General & Internal

Current Diagnosis and Management of Small-Cell Lung Cancer

Shuhang Wang et al.

MAYO CLINIC PROCEEDINGS (2019)

Article Biochemistry & Molecular Biology

Methylation of UHRF1 by SET7 is essential for DNA double-strand break repair

Ja Young Hahm et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Medicine, General & Internal

First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer

L. Horn et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Oncology

YAP/TAZ at the Roots of Cancer

Francesca Zanconato et al.

CANCER CELL (2016)

Article Multidisciplinary Sciences

Replication fork stability confers chemoresistance in BRCA-deficient cells

Arnab Ray Chaudhuri et al.

NATURE (2016)

Editorial Material Cell Biology

Small cell lung cancer: Time to revisit DNA-damaging chemotherapy

Anish Thomas et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

Article Multidisciplinary Sciences

A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice

Haoxing Zhang et al.

NATURE COMMUNICATIONS (2016)

Article Cell Biology

Ectopic Activation of Germline and Placental Genes Identifies Aggressive Metastasis-Prone Lung Cancers

Sophie Rousseaux et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

Article Oncology

Yes-Associated Protein 1 Is Activated and Functions as an Oncogene in Meningiomas

Gilson S. Baia et al.

MOLECULAR CANCER RESEARCH (2012)

Article Oncology

UHRF1 is a novel diagnostic marker of lung cancer

M. Unoki et al.

BRITISH JOURNAL OF CANCER (2010)