Letter to the Editor: clinical utility of urine DNA for noninvasive detection and minimal residual disease monitoring in urothelial carcinoma

Review Urology & Nephrology

European Association of Urology Guidelines on Non-muscle-invasive Bladder Cancer (Ta, T1, and Carcinoma in Situ)

Marko Babjuk et al.

Summary: The updated EAU guidelines provide new information on the diagnosis and treatment of NMIBC for clinical practice. Individual risk assessment is crucial in determining the appropriate treatment for patients with different risk levels. Surgical intervention, including radical cystectomy, may be necessary for cases unresponsive to BCG treatment or with high risk of progression.

EUROPEAN UROLOGY (2022)

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Review Urology & Nephrology

European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2020 Update

Morgan Roupret et al.

Summary: The updated EAU guidelines on UTUC aim to assist clinicians in evidence-based management, providing recommendations on diagnosis, risk stratification, radical and conservative treatment, and prognostic factors. Due to the rarity of UTUC, there is insufficient data to provide strong recommendations. Recommendations are based on the 2017 TNM classification and emphasize individualized treatment based on proposed risk stratification.

EUROPEAN UROLOGY (2021)

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Review Oncology

Urinary biomarkers in bladder cancer: A review of the current landscape and future directions

Kenrick Ng et al.

Summary: This narrative review discusses established and emerging urinary biomarkers for non-muscle invasive bladder cancer, highlighting the limitations of classical FDA-approved protein biomarkers. Advancements in epigenetic and genetic markers as well as extracellular vesicles have shown promise in enhancing sensitivity and specificity in bladder cancer diagnosis. The future focus will be on utilizing these markers in combination to create predictive signatures for everyday clinical practice.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2021)

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Article Medicine, General & Internal

Urine tumor DNA detection of minimal residual disease in muscle-invasive bladder cancer treated with curative-intent radical cystectomy: A cohort study

Pradeep S. Chauhan et al.

Summary: The study aimed to develop a noninvasive liquid biopsy method for urine DNA analysis to assist in selecting patients suitable for bladder-sparing treatment.

PLOS MEDICINE (2021)

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Article Medical Laboratory Technology