Is losartan a promising agent for the treatment of type 1 diabetes-induced testicular germ cell apoptosis in rats?

Article Chemistry, Multidisciplinary

Fluvastatin alleviates doxorubicin-induced cardiac and renal toxicity in rats via regulation of oxidative stress, inflammation, and apoptosis associated genes expressions

Gokce Ceren Kuscu et al.

Summary: Fluvastatin may be a candidate agent for the prevention of renal and cardiac toxicities in cancer patients receiving doxorubicin chemotherapy.

DRUG AND CHEMICAL TOXICOLOGY (2023)

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Review Andrology

Effects of diabetes mellitus on sperm quality and fertility outcomes: Clinical evidence

Francesco Lotti et al.

Summary: Diabetes mellitus has a negative effect on sperm quality and male/couple fertility, but studies on this topic have been limited and have shown inconsistent results.

ANDROLOGY (2023)

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Article Biochemistry & Molecular Biology

The Effects of Separate and Combined Treatment of Male Rats with Type 2 Diabetes with Metformin and Orthosteric and Allosteric Agonists of Luteinizing Hormone Receptor on Steroidogenesis and Spermatogenesis

Andrey A. Bakhtyukov et al.

Summary: In males with type 2 diabetes mellitus, metformin and LH/hCG-R agonists can restore steroidogenesis and spermatogenesis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Nobiletin protects against diabetes-induced testicular injury via hypophysis-gonadal axis upregulation and amelioration of oxidative stress

Marwa Salah et al.

Summary: This study demonstrated that nobiletin has protective effects against diabetes-induced testicular injury by reducing oxidative stress, hyperglycemia, inflammation, and caspase-3, and by regulating hormone levels and androgen receptors. The high dose of nobiletin was more effective in restoring the functions of testicular tissues in diabetic rats.

MOLECULAR BIOLOGY REPORTS (2022)

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Review Andrology

The impact of diabetes mellitus type 1 on male fertility: Systematic review and meta-analysis

Paolo Facondo et al.

Summary: Studies have shown that men with DM1 have a lower paternity rate, especially those with longer disease duration. The data on gonadal hormonal profile in DM1 men are heterogeneous, making it difficult to draw definitive conclusions. Meta-analysis indicates that men with DM1 have poorer sperm morphology, progressive motility, and a trend towards lower seminal volume compared to controls.

ANDROLOGY (2022)

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Article Chemistry, Multidisciplinary

Effects of ellagic acid in the testes of streptozotocin induced diabetic rats

Saadet Ozen Akarca Dizakar et al.

Summary: This study investigated the effects of ellagic acid (EA) treatment on diabetes-induced testicular damage, and found that EA may have a protective effect on reducing the damage caused by diabetes in the testis.

DRUG AND CHEMICAL TOXICOLOGY (2022)

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Article Biochemistry & Molecular Biology

Losartan Alleviates the Side Effects and Maintains the Anticancer Activity of Axitinib

Ying Fu et al.

Summary: The study found that losartan can alleviate the side effects caused by axitinib without affecting its antitumor activity. This study provides important information for overcoming side effects related to VEGF receptor inhibitors.

MOLECULES (2022)

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Review Pathology

Histomorphometric and oxidative evaluation of the offspring's testis from type 2 diabetic female rats treated with metformin and pentoxifylline

Jessica Santana de Oliveira et al.

Summary: This study investigated the effects of intrauterine exposure to type 2 diabetes mellitus (T2D) on testicular histomorphometry and redox homeostasis in adult rats, and evaluated the effects of maternal treatment with metformin and pentoxifylline. The results showed that metformin protected the tubular compartment of the testicles, while pentoxifylline attenuated the effects of diabetes on Leydig cells.

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (2022)

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Article Biochemistry & Molecular Biology

Protective Effect of Portulaca oleracea on Streptozotocin-Induced Type I Diabetes-Associated Reproductive System Dysfunction and Inflammation

Hassan Rakhshandeh et al.

Summary: The study found that Portulaca oleracea extract has a protective effect on streptozotocin-induced type-I-diabetes-associated reproductive system dysfunction and inflammation in rats. It ameliorated various parameters and histopathological indexes' damage, indicating its potential use in managing diabetic-associated clinical complications.

MOLECULES (2022)

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Review Endocrinology & Metabolism

A systematic review on the role of melatonin and its mechanisms on diabetes-related reproductive impairment in non-clinical studies

Maryam Armandeh et al.

Summary: This review explores the mechanisms of melatonin's effect on reproductive system damage caused by diabetes. Studies suggest that melatonin can improve the impact of diabetes on reproductive tissues and has antioxidant, anti-apoptotic, and anti-inflammatory effects.

FRONTIERS IN ENDOCRINOLOGY (2022)

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Review Public, Environmental & Occupational Health

Oxidative Stress and Male Infertility: Evidence From a Research Perspective

Bashir Ayad et al.

Summary: This review provides a novel insight into the impact of oxidative stress (OS) on sperm and male reproductive function. It summarizes the findings from various studies conducted by Stellenbosch University Reproductive Research Group (SURRG) and other investigators, and highlights the advances in assessing OS. The review also discusses the association between OS and ejaculatory abstinence period, as well as the role of OS in the pathophysiology of systemic diseases and its potential implications in clinical practice.

FRONTIERS IN REPRODUCTIVE HEALTH (2022)

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Article Medicine, General & Internal