期刊
MICRON
卷 164, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micron.2022.103384
关键词
Hertz model; Heterogeneous samples; Fitting; Mechanical characterization; Depth dependent behavior; Biological samples
类别
This paper provides conclusive answers to the mathematical question regarding the fitting approach in testing soft biological samples and introduces a new tool, depth-dependent mechanical properties maps, for nanomechanical characterization of biological samples.
When testing soft biological samples using the Atomic Force Microscopy (AFM) nanoindentation method, the force-indentation data is usually fitted to the equations provided by Hertzian mechanics. Nevertheless, a significant question remains up to date; is this a correct approach from a mathematical perspective? Biological materials are heterogeneous, so 'what do we calculate' when using a classic fitting approach? In this paper, conclusive answers to the abovementioned questions are provided. In addition, a new tool for the nanomechanical characterization of biological samples, the depth-dependent mechanical properties maps, is introduced.
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