期刊
CELL
卷 163, 期 2, 页码 456-492出版社
CELL PRESS
DOI: 10.1016/j.cell.2015.09.029
关键词
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资金
- EPFL
- ETH Domain for the Blue Brain Project (BBP)
- European Union [604102]
- Gatsby Charitable Foundation
- Cajal Blue Brain Project, Ministerio de Economia y Competitividad Spanish Ministry of Education and Science
- EPFL-Hebrew University Collaborative Grant
- Canton of Geneva
- Canton of Vaud
- Hans Wilsdorf Foundation
- Louis-Jeantet Foundation
- University of Geneva
- University of Lausanne
- Ecole Polytechnique Federale de Lausanne
- ETH Board Funding
We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse experimental data. An objective anatomical method defines a neocortical volume of 0.29 +/- 0.01 mm(3) containing similar to 31,000 neurons, and patch-clamp studies identify 55 layer-specific morphological and 207 morphoelectrical neuron subtypes. When digitally reconstructed neurons are positioned in the volume and synapse formation is restricted to biological bouton densities and numbers of synapses per connection, their overlapping arbors form similar to 8 million connections with similar to 37 million synapses. Simulations reproduce an array of in vitro and in vivo experiments without parameter tuning. Additionally, we find a spectrum of network states with a sharp transition from synchronous to asynchronous activity, modulated by physiological mechanisms. The spectrum of network states, dynamically reconfigured around this transition, supports diverse information processing strategies.
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