4.7 Article

Omicron variant: Current insights and future directions

期刊

MICROBIOLOGICAL RESEARCH
卷 265, 期 -, 页码 -

出版社

ELSEVIER GMBH
DOI: 10.1016/j.micres.2022.127204

关键词

Omicron; Spike proteins; Transmissibility; Vaccine; Diagnosis

资金

  1. Sir Ganga Ram Hospital, Delhi, India

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The identification of the SARS-CoV-2 Omicron variant has raised concerns globally, as it may have a higher rate of transmission and a significant number of mutations, potentially impacting the control and treatment of the pandemic. The World Health Organization has designated this variant as a variant of concern and named it Omicron. The transmission method and severity of Omicron have been well defined, but there are still many speculations regarding its origin and infectivity.
The global COVID-19 outbreak has returned with the identification of the SARS-CoV-2 Omicron variant (B.1.1.529) after appearing to be persistently spreading for the more than past two years. In comparison to prior SARS-CoV-2 variants, this new variant revealed a significant amount of mutation. This novel variety may have a greater rate of transmissibility which might impede the effectiveness of current diagnostic equipment as well as vaccination efficacy and also impede immunotherapies (Antibody / monoclonal antibody based). WHO designated B.1.1.529 as a variant of concern on November 26, 2021, identified as Omicron. The Omicron variant transmission method and severity, on the other hand, are well defined. The global spread of Omicron, which has now seized many nations, has resulted in numerous speculations regarding its origin and degree of infectivity. The following sections will go over its potential for transmission, omicron structure, and impact on COVID-19 vaccines, how it is different from delta variant and diagnostics.

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