期刊
MICROBIAL PATHOGENESIS
卷 174, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micpath.2022.105905
关键词
Salmonella; Virulence genes; Ilex paraguariensis; Antibacterial activity; Antimicrobial resistance
This study investigated the antibacterial activity of Ilex paraguariensis extract against different strains of nontyphoidal Salmonella. The extract showed varying MIC values and a high MPC, resulting in a wide MSW range. Several pathogenicity genes were detected in the Salmonella isolates. The antibacterial activity of the extract was not affected by antimicrobial resistance or pathogenicity genes, suggesting the presence of other active compounds.
This study investigated the antibacterial activity of the aqueous extract of Ilex paraguariensis against 32 different strains of nontyphoidal Salmonella (NTS) through the determination of the minimum inhibitory concentration (MIC), mutant prevention concentration (MPC), and mutant selection window (MSW) and the detection of virulence genes by multiplex PCR assays. The MIC values of Ilex paraguariensis against Salmonella spp. strains varied between 0.78 mg/ml and 6.25 mg/ml with a MIC90 of 3.12 mg/ml. The highest MPC in this study was 48 mg/ml yielding a mutant selection window of 41.75 mg/ml. The MSW values of the remaining strains varied between 1.56 and 8.87 mg/ml. Genes of pathogenicity detected in Salmonella spp. isolates were most commonly the stn, sdiA, invA, sopB, invH, and sopE genes. The antibacterial activity of yerba mate extract was not affected by the antimicrobial resistance patterns or pathogenicity genes expressed. More work is needed to identify the active antibacterial compound(s) responsible for the antibacterial activity.
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