期刊
MICROBIAL DRUG RESISTANCE
卷 28, 期 12, 页码 1087-1098出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/mdr.2022.0094
关键词
multidrug resistance; extensive drug resistance; pan drug resistance; efflux pump; H58 subtyping
资金
- Higher Education Commission of Pakistan under the research grant NRPU
- [3456]
This study investigated the current scenario of antimicrobial resistance in Salmonella Typhi isolates and found a significant rise in resistance against multiple antibiotics. The presence of carbapenemase genes in Salmonella Typhi, which is rare in Enterobacteriaceae, was also identified. Furthermore, the regional differences in the genetic variation and resistance patterns of Salmonella Typhi require further epidemiological studies.
Rapid emergence of resistance in Salmonella enterica serovar Typhi (Salmonella Typhi) against most of the available therapeutic options for typhoid has rendered its treatment more difficult. This study sought to determine the current scenario of antimicrobial resistance in local isolates of Faisalabad following several treatment failure reports. Out of 300 clinical specimens collected in 2018, 45 isolates were identified as Salmonella Typhi. To assess changes, we compared their antibiogram profile with 31 Salmonella Typhi strains isolated in 2005. The isolates collected during 2018 showed a significant rise in antimicrobial drug resistance as compared with isolates revived from the cultures of 2005, including 15 multidrug-resistant (MDR), 20 extensively drug-resistant, and 14 pan drug-resistant isolates compared with only 8 MDRs from 2005. Notably, in 2018 isolates, resistance to azithromycin was seen in 75% of the isolates. Extended-spectrum beta-lactamase production was detected in 47% of Salmonella Typhi isolates and 18% isolates showed resistance against carbapenems. The sequences of two carbapenemase genes, VIM and GES, found in Salmonella Typhi were submitted in NCBI. The carbapenem resistance is rare in Enterobacteriaceae and probably first time reported in Salmonella Typhi. H58 haplotype was identified in the 2018 Salmonella Typhi isolates and PCR-restriction fragment length polymorphism method identified 16.7% of H58 strains that belonged to lineage I, 19.4% of H58 strains that belonged to lineage II, and the remaining 63.9% that belonged to the node. The regional difference in the antimicrobial resistance trend needs effective epidemiological studies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据