Aluminium trichloride-promoted tandem hydroarylation-ionic hydrogenation of 3-arylpropynoic acid derivatives and 4-phenylbut-3-yn-2-one

Reactions of 3-arylpropynoic acid derivatives and conjugated acetylene ketones with arenes and cyclohexane under the action of AlCl3 at room temperature for 15 h afford the corresponding products of one-pot tandem hydroarylation- ionic hydrogenation of the acetylene bond of the starting compounds in 42-98% yields. This reaction is accompanied by aryl group exchange process under acidic conditions.

Automated summary

Reaction of 3-arylpropynoic acid derivatives and conjugated acetylene ketones with arenes and cyclohexane in the presence of AlCl3 at room temperature for 15 h results in one-pot tandem hydroarylation-ionic hydrogenation of the acetylene bond with yields ranging from 42% to 98%. This reaction is accompanied by aryl group exchange under acidic conditions.