4.3 Review

Marine-derived Natural Products as Anticancer Agents

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Medicinal

Extremophilic Fungi from Marine Environments: Underexplored Sources of Antitumor, Anti-Infective and Other Biologically Active Agents

Lesley-Ann Giddings et al.

Summary: Marine environments hold vast potential for the discovery of bioactive metabolites, with marine fungi being an untapped source. This review discusses the cytotoxic and anti-infective fungal metabolites isolated from extreme marine environments and explores cultivation strategies to increase their production.

MARINE DRUGS (2022)

Review Pharmacology & Pharmacy

Repurposing small-molecule drugs for modulating toxic protein aggregates in neurodegenerative diseases

Wei Liu et al.

Summary: Neurodegenerative diseases are common age-related disorders without effective therapies. Recent studies have found a link between some neurodegenerative diseases and toxic protein aggregates, suggesting that mimicking these aggregates may be a promising therapeutic strategy. Repurposing existing drugs for other indications has also gained attention as a potential treatment approach. This review focuses on summarizing repurposed small-molecule drugs for neurodegenerative diseases and discussing their molecular mechanisms.

DRUG DISCOVERY TODAY (2022)

Article Integrative & Complementary Medicine

Isolation and Characterization of Antibacterial Compounds from Aspergillus fumigatus: An Endophytic Fungus from a Mangrove Plant of the Sundarbans

S. M. Neamul Kabir Zihad et al.

Summary: This study isolated fourteen endophytic fungi from the Sundarbans, five identified as Aspergillus sp. and one as Penicillium sp. The research revealed varying degrees of antibacterial activity against different bacteria species, which could be attributed to the compounds produced by these endophytes.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

Review Biotechnology & Applied Microbiology

Anti-cancer peptides: their current trends in the development of peptide-based therapy and anti-tumor drugs

Amit Lath et al.

Summary: The article discusses the importance and advantages of anti-cancer peptides as a treatment option in cancer therapy. These peptides have high selectivity, penetration efficiency, and low toxicity to normal cells, providing a new approach to expanding cancer treatment. Understanding the structure and function of anti-cancer peptides is crucial for improving cancer prevention and treatment methods.

BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS (2022)

Review Microbiology

Squalamine and Its Aminosterol Derivatives: Overview of Biological Effects and Mechanisms of Action of Compounds with Multiple Therapeutic Applications

Nour Mammari et al.

Summary: Squalamine and its derivatives have shown potent antibacterial, antifungal, antiprotozoa, and antiviral activities. They also exhibit potential positive effects in cancer treatment and other diseases. This review provides an overview of the various effects of squalamine and its derivatives, as well as the mechanisms of their actions on the human organism and different pathogens.

MICROORGANISMS (2022)

Review Biotechnology & Applied Microbiology

Promising bioactive compounds from the marine environment and their potential effects on various diseases

Akash Karthikeyan et al.

Summary: Marine organisms are promising biocatalysts with resistance to harsh conditions, playing a crucial role in new industrial processes; Biologically active compounds derived from marine resources, such as antibiotics, antivirals, and anticancer agents, have significant pharmaceutical potential; The bioactive compounds from marine sources have shown therapeutic effects in various diseases, indicating their potential contribution to human health.

JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY (2022)

Review Pharmacology & Pharmacy

Flavonoids from Marine-Derived Actinobacteria as Anticancer Drugs

Wael N. Hozzein et al.

Summary: Flavonoids, a diverse group of natural products, are traditionally used as medicine against various infectious diseases and have numerous biological activities. Actinobacteria, known for producing bioactive compounds, are highlighted for their potential to produce flavonoids with anticancer properties, particularly from marine sources.

CURRENT PHARMACEUTICAL DESIGN (2021)

Article Medicine, Research & Experimental

Marine-derived drugs: Recent advances in cancer therapy and immune signaling

Abdullah F. U. H. Saeed et al.

Summary: The marine environment is a significant source for marine-derived natural products and anticancer drug research, with potential for innovative developments. Challenges and limitations exist in the development of FDA-approved marine-derived anticancer drugs. The use of chitosan in marine-derived drugs shows promise as a prolific anticancer drug delivery system, while immune signaling pathways and JAK/STAT pathways play crucial roles in anticancer therapy and require further study.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Biochemistry & Molecular Biology

Application of marine natural products in drug research

Wen-Yu Lu et al.

Summary: With the changing environment, new diseases are emerging. The development of bioactive substances from the marine environment is providing new resources for the production of new drugs to combat major diseases such as cancer or inflammation. Currently, many marine-derived drugs are in preclinical or early stage of clinical development, and some have already been put on the market.

BIOORGANIC & MEDICINAL CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Antitumor Effects of Ursolic Acid through Mediating the Inhibition of STAT3/PD-L1 Signaling in Non-Small Cell Lung Cancer Cells

Dong Young Kang et al.

Summary: Targeted therapy using natural compounds, such as ursolic acid (UA), shows promising effects against non-small cell lung cancer by inhibiting proliferation, inducing cell cycle arrest and apoptosis, and suppressing tumor angiogenesis through EGFR/JAK2/STAT3 signaling pathway.

BIOMEDICINES (2021)

Review Chemistry, Medicinal

Marine Power on Cancer: Drugs, Lead Compounds, and Mechanisms

Lichuan Wu et al.

Summary: Around 19.3 million new cancer cases and almost 10.0 million cancer deaths occur worldwide each year. Attention has recently been focused on the ocean as a potential source of novel drugs to fight against malignant neoplasms. Marine compounds have shown promising anticancer activity, but few drugs have been approved for specific cancer treatments by the U.S. Food and Drug Administration.

MARINE DRUGS (2021)

Article Pharmacology & Pharmacy

HPTLC analysis of Fumaria parviflora (Lam.) methanolic extract of whole plant

Anjali Bhargava et al.

Summary: The study found that the methanolic extract of the whole plant of F. parviflora contains a diverse range of phytochemicals, which may contribute to its therapeutic value, supporting its traditional use in India.

FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

Article Chemistry, Medicinal

Cladodionen Is a Potential Quorum Sensing Inhibitor Against Pseudomonas aeruginosa

Mengjia Wang et al.

MARINE DRUGS (2020)

Letter Chemistry, Multidisciplinary

A new asymmetric diketopiperazine dimer from the sponge-associated fungus Aspergillus versicolor 16F-11

Bin-Bin Gu et al.

MAGNETIC RESONANCE IN CHEMISTRY (2019)

Review Chemistry, Medicinal

The Phylum Bryozoa as a Promising Source of Anticancer Drugs

Blanca Figuerola et al.

MARINE DRUGS (2019)

Article Chemistry, Medicinal

Marine Natural Products: A Source of Novel Anticancer Drugs

Shaden A. M. Khalifa et al.

MARINE DRUGS (2019)

Article Biochemistry & Molecular Biology

Discovery of antitumor ursolic acid long-chain diamine derivatives as potent inhibitors of NF-κB

Wei Jiang et al.

BIOORGANIC CHEMISTRY (2018)

Review Biochemistry & Molecular Biology

Therapeutic Properties and Biological Benefits of Marine-Derived Anticancer Peptides

Hee Kyoung Kang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Biotechnology & Applied Microbiology

JBIR-150, a novel 20-membered polyene macrolactam from marine-derived Streptomyces sp. OPMA00071

Teppei Kawahara et al.

JOURNAL OF ANTIBIOTICS (2018)

Review Chemistry, Medicinal

Molecular Targets of Active Anticancer Compounds Derived from Marine Sources

Xiaoping Song et al.

MARINE DRUGS (2018)

Article Chemistry, Multidisciplinary

New Anti-inflammatory Cyclopeptides From a Sponge-Derived Fungus Aspergillus violaceofuscus

Jingtang Liu et al.

FRONTIERS IN CHEMISTRY (2018)

Article Oncology

The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion

Chunwan Lu et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

Article Biochemistry & Molecular Biology

Mitochondria-targeted betulinic and ursolic acid derivatives: synthesis and anticancer activity

Darya A. Nedopekina et al.

MEDCHEMCOMM (2017)

Article Oncology

The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion

Chunwan Lu et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

Article Biochemistry & Molecular Biology

Design, synthesis, and evaluation of novel ursolic acid derivatives as HIF-1α inhibitors with anticancer potential

Ke-Qiang Chi et al.

BIOORGANIC CHEMISTRY (2017)

Article Chemistry, Medicinal

Targeting cancer cells with oleanolic and ursolic acid derived hydroxamates

Jana Wiemann et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)

Article Chemistry, Medicinal

Synthesis and evaluation as potential antitumor agents of novel ursolic acid derivatives

Ming-Chuan Liu et al.

MEDICINAL CHEMISTRY RESEARCH (2016)

Article Chemistry, Medicinal

Design, synthesis and in vitro evaluation of novel ursolic acid derivatives as potential anticancer agents

Shi-Xian Hua et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)

Article Chemistry, Multidisciplinary

New diketopiperazine dimer from a filamentous fungal isolate of Aspergillus sydowii

Amninder Kaur et al.

MAGNETIC RESONANCE IN CHEMISTRY (2015)

Review Chemistry, Medicinal

Can Some Marine-Derived Fungal Metabolites Become Actual Anticancer Agents?

Nelson G. M. Gomes et al.

MARINE DRUGS (2015)

Article Plant Sciences

Total Synthesis and Structural Revision of (+)-Cristatumin C

Paula Lorenzo et al.

JOURNAL OF NATURAL PRODUCTS (2014)

Article Plant Sciences

Heronamides D-F, Polyketide Macrolactams from the Deep-Sea-Derived Streptomyces sp SCSIO 03032

Wenjun Zhang et al.

JOURNAL OF NATURAL PRODUCTS (2014)

Letter Biochemistry & Molecular Biology

Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases Reply

Dorothea Greiner et al.

NATURE CHEMICAL BIOLOGY (2013)

Article Chemistry, Medicinal

Cristatumins A-D, new indole alkaloids from the marine-derived endophytic fungus Eurotium cristatum EN-220

Feng-Yu Du et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)

Article Pharmacology & Pharmacy

Glycogen Synthase Kinase 3 as an Anticancer Drug Target: Novel Experimental Findings and Trends in the Design of Inhibitors

Dmitry I. Osolodkin et al.

CURRENT PHARMACEUTICAL DESIGN (2012)

Article Biotechnology & Applied Microbiology

Cytotoxic epipolythiodioxopiperazine alkaloids from filamentous fungi of the Bionectriaceae

Mario Figueroa et al.

JOURNAL OF ANTIBIOTICS (2012)

Article Oncology

Reports of Clinical Benefit of Plitidepsin (Aplidine), a New Marine-Derived Anticancer Agent, in Patients With Advanced Medullary Thyroid Carcinoma

Christophe Le Tourneau et al.

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS (2010)

Article Biochemistry & Molecular Biology

Synthesis of the Marine Bromotyrosine Psammaplin F and Crystal Structure of a Psammaplin A Analogue

Qianjiao Yang et al.

MOLECULES (2010)

Review Oncology

Anticancer Drugs from Marine Flora: An Overview

N. Sithranga Boopathy et al.

JOURNAL OF ONCOLOGY (2010)

Article Plant Sciences

Bionectins A-C, epidithiodioxopiperazines with anti-MRSA activity, from Bionectra byssicola F120

Chang-Ji Zheng et al.

JOURNAL OF NATURAL PRODUCTS (2006)

Article Biotechnology & Applied Microbiology

Streptokordin, a new cytotoxic compound of the methylpyridine class from a marine-derived Streptomyces sp KORDI-3238

Seong-Yun Jeong et al.

JOURNAL OF ANTIBIOTICS (2006)

Article Plant Sciences

Nematicidal epipolysulfanyldioxopiperazines from Gliocladium roseum

JY Dong et al.

JOURNAL OF NATURAL PRODUCTS (2005)

Article Biochemistry & Molecular Biology

Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9

D Greiner et al.

NATURE CHEMICAL BIOLOGY (2005)

Article Plant Sciences

A diketopiperazine dimer from a marine-derived isolate of Aspergillus niger

SPB Ovenden et al.

JOURNAL OF NATURAL PRODUCTS (2004)

Review Pharmacology & Pharmacy

Marine-derived anticancer agents in clinical trials

G Schwartsmann et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2003)

Article Chemistry, Multidisciplinary

Enantioselective total syntheses of ditryptophenaline and ent-WIN 64821

LE Overman et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)

Review Oncology

Marine organisms as a source of new anticancer agents

Gilberto Schwartsmann et al.

LANCET ONCOLOGY (2001)