期刊
MEDICAL PHYSICS
卷 50, 期 4, 页码 2590-2606出版社
WILEY
DOI: 10.1002/mp.16059
关键词
genomics; heterogeneity; machine learning; multiparametric; multiscale
This article proposes a new method for mapping cellular and molecular features in vivo to improve cancer treatment strategies in the brain. The method leverages the advantages of in vivo imaging, functional magnetic resonance signals, next-generation sequencing, and deep learning techniques. It also outlines design protocols to integrate bioinformation technologies, increased computational capability, and statistical classification techniques for rational treatment selection.
Resistance of high grade tumors to treatment involves cancer stem cell features, deregulated cell division, acceleration of genomic errors, and emergence of cellular variants that rely upon diverse signaling pathways. This heterogeneous tumor landscape limits the utility of the focal sampling provided by invasive biopsy when designing strategies for targeted therapies. In this roadmap review paper, we propose and develop methods for enabling mapping of cellular and molecular features in vivo to inform and optimize cancer treatment strategies in the brain. This approach leverages (1) the spatial and temporal advantages of in vivo imaging compared with surgical biopsy, (2) the rapid expansion of meaningful anatomical and functional magnetic resonance signals, (3) widespread access to cellular and molecular information enabled by next-generation sequencing, and (4) the enhanced accuracy and computational efficiency of deep learning techniques. As multiple cellular variants may be present within volumes below the resolution of imaging, we describe a mapping process to decode micro- and even nano-scale properties from the macro-scale data by simultaneously utilizing complimentary multiparametric image signals acquired in routine clinical practice. We outline design protocols for future research efforts that marry revolutionary bioinformation technologies, growing access to increased computational capability, and powerful statistical classification techniques to guide rational treatment selection.
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