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In Reply: ACEI and ARB - Each Unique RAAS Inhibitors: The Importance of Impact on Inflammation

MAYO CLINIC PROCEEDINGS (2023)

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Review Peripheral Vascular Disease

Renin Angiotensin Blockers and Cardiac Protection: From Basis to Clinical Trials

Bernard Levy et al.

Summary: Despite similar effects on blood pressure, ARBs have been found to have higher cardiovascular mortality and lower protection against myocardial infarction compared to ACEIs. The different effects may be due to the specific actions of ACEIs on bradykinin and nitric oxide, while chronic blockade of AT1 receptors by ARBs may result in overstimulation of angiotensin II and activation of potentially harmful receptors.

AMERICAN JOURNAL OF HYPERTENSION (2022)

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Review Medicine, General & Internal

Effect of the Renin-Angiotensin System Inhibitors on Inflammatory Markers: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Kamal Awad et al.

Summary: This meta-analysis found that ACEIs significantly reduced plasma levels of CRP, IL-6, and TNF-a, while ARBs were effective in reducing IL-6 only.

MAYO CLINIC PROCEEDINGS (2022)

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Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers in Patients Without Heart Failure? Insights From 254,301 Patients From Randomized Trials

Sripal Bangalore et al.

MAYO CLINIC PROCEEDINGS (2016)

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Article Cardiac & Cardiovascular Systems

A Meta-Analysis Reporting Effects of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Patients Without Heart Failure

Gianluigi Savarese et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2013)

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Article Cardiac & Cardiovascular Systems

Angiotensin-converting enzyme inhibitors reduce mortality in hypertension: a meta-analysis of randomized clinical trials of reninangiotensinaldosterone system inhibitors involving 158 998 patients

Laura C. van Vark et al.

EUROPEAN HEART JOURNAL (2012)

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Effects of olmesartan on renal and cardiovascular outcomes in type 2 diabetes with overt nephropathy: a multicentre, randomised, placebo-controlled study

E. Imai et al.

DIABETOLOGIA (2011)

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Irbesartan in Patients with Atrial Fibrillation

NEW ENGLAND JOURNAL OF MEDICINE (2011)

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Effect of Valsartan on the Incidence of Diabetes and Cardiovascular Events

John J. McMurray et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

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Valsartan for Prevention of Recurrent Atrial Fibrillation

Marcello Disertori et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

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Telmisartan, ramipril, or both in patients at high risk for vascular events

Salim Yusuf et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

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Telmisartan to prevent recurrent stroke and cardiovascular events

Salim Yusuf et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

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Use of ramipril in preventing stroke: double blind randomised trial

J Bosch et al.

BMJ-BRITISH MEDICAL JOURNAL (2002)

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Article Endocrinology & Metabolism

Low-dose ramipril reduces microalbuminuria in type 1 diabetic patients without hypertension results of a randomized controlled trial - Results of a randomized controlled trial

JP O'Hare et al.

DIABETES CARE (2000)

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