Ageotypes revisited: The brain and central nervous system dysfunction as a major nutritional and lifestyle target for healthy aging

Undeniably, biological age can significantly differ between individuals of similar chronological age. Longitudinal, deep multi-omic profiling has recently enabled the identification of individuals with distinct aging phenotypes, termed 'ageotypes'. This effort has provided a plethora of data and new insights into the diverse molecular mechanisms presumed to drive aging. Translational opportunities stemming from this knowledge continue to evolve, providing an opportunity for the provision of nutritional interventions aiming to decelerate the aging process. In this framework, the contemporary ageotypes classification was revisited via in silico analyses, with the brain and nervous system being identified as the primary targets of age-related biomolecules, acting through inflammatory and metabolic pathways. Nutritional and lifestyle factors affecting these pathways in the brain and central nervous system that could help guide personalized recommendations for the attainment of healthy aging are discussed.

Automated summary

Undeniably, there is a significant variation in biological age among individuals with similar chronological age. Through deep multi-omic profiling, researchers have identified distinct aging phenotypes known as 'ageotypes'. This research has provided valuable insights into the molecular mechanisms underlying aging and has led to potential opportunities for nutritional interventions to slow down the aging process.