Natural Products from Chilean and Antarctic Marine Fungi and Their Biomedical Relevance

Article Biotechnology & Applied Microbiology

Isolation and agricultural potential of penicillic acid against citrus canker

Gabrielle Vieira et al.

Summary: Penicillic acid isolated from Penicillium sp. CRM 1540, a fungus from Antarctica marine sediment, shows potential as an alternative for controlling citrus canker, with a significant decrease in lesion number.

JOURNAL OF APPLIED MICROBIOLOGY (2022)

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Article Plant Sciences

Cytotoxic Nitrobenzoyl Sesquiterpenoids from an Antarctica Sponge-Derived Aspergillus insulicola

Chunxiao Sun et al.

Summary: Four new compounds were isolated from a fungus derived from an Antarctica sponge, and compound 4 showed selective inhibition against PDAC cells, suppressing cell proliferation and inducing apoptosis. It also blocked cell migration and invasion and improved the therapeutic effect of the chemotherapy drug gemcitabine. Mechanism studies revealed that compound 4 can inhibit the expression of EGFR and XIAP in PDAC cells.

JOURNAL OF NATURAL PRODUCTS (2022)

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Article Chemistry, Medicinal

Citromycin Isolated from the Antarctic Marine-Derived Fungi, Sporothrix sp., Inhibits Ovarian Cancer Cell Invasion via Suppression of ERK Signaling

He Yun Choi et al.

Summary: Citromycin inhibits the migration and invasion of human ovarian cancer cells by downregulating the expression levels of EMT markers and MMP-2/9 via inhibition of the ERK1/2 pathway.

MARINE DRUGS (2022)

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Article Chemistry, Organic

Talaverrucin A, Heterodimeric Oxaphenalenone from Antarctica Sponge-Derived Fungus Talaromyces sp. HDN151403, Inhibits Wnt/ β-Catenin Signaling Pathway

Chunxiao Sun et al.

Summary: A novel Wnt/β-catenin inhibitor talaverrucin A was discovered, which showed inhibitory activity on the Wnt/β-catenin pathway in both in vivo and in vitro experiments. This provides a potential lead for developing new drugs targeting this pathway.

ORGANIC LETTERS (2022)

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Article Chemistry, Organic

Xanalterate A, altertoxin VIII and IX, perylenequinone derivatives from antarctica-sponge-derived fungus Alternaria sp. HDN19-690

Zhaoxia Hou et al.

Summary: In this study, three new perylenequinone derivatives and one known analogue were isolated from the extract of an Antarctic sponge-derived fungus. The structures and antimicrobial activity of these compounds were confirmed.

TETRAHEDRON LETTERS (2022)

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Review Chemistry, Medicinal

Deep-Sea Natural Products from Extreme Environments: Cold Seeps and Hydrothermal Vents

Mengjing Cong et al.

Summary: The deep sea is a treasure trove of structurally unique and biologically active natural products. Cold seeps and hydrothermal vents, as representative extreme environments in the deep sea, have attracted increasing attention. This review provides a summary of natural products from deep-sea cold seeps and hydrothermal vents derived from marine animals, marine fungi, and marine bacteria, as well as their biological activities. In total, 182 compounds have been reported, citing 132 references, covering literature from 1984 to March 2022. Compounds from genera such as Aspergillus sp., Penicillium sp., and Streptomyces sp. are the main sources. Notably, 90 of the 182 compounds are newly discovered, and almost 60% of the reported structures exhibit diverse bioactivities, making them attractive targets for further organic synthetic and biosynthetic studies.

MARINE DRUGS (2022)

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Review Chemistry, Medicinal

Recent Discoveries on Marine Organism Immunomodulatory Activities

Eleonora Montuori et al.

Summary: Marine organisms are a valuable source of biologically active compounds for the prevention and treatment of various diseases. The study of these organisms is advantageous due to the wide biodiversity and chemical diversity of marine natural products. Many studies focus on marine compounds with potential pharmaceutical applications, particularly as immunomodulators for cancer and immune-mediated diseases.

MARINE DRUGS (2022)

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Review Biochemistry & Molecular Biology

Marine natural products

Anthony R. Carroll et al.

Summary: This review summarizes the literature on marine natural products (MNPs) published in 2020, covering a wide range of compounds isolated from various marine organisms. The focus is on new compounds discovered in 2020, including their biological activities, source organisms, and country of origin. The review also includes a meta analysis of bioactivity data for new MNPs reported in the past five years.

NATURAL PRODUCT REPORTS (2022)

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Article Biotechnology & Applied Microbiology

In Vitro Evaluation of the Photoprotective Potential of Quinolinic Alkaloids Isolated from the Antarctic Marine Fungus Penicillium echinulatum for Topical Use

Thaiz Rodrigues Teixeira et al.

Summary: This study evaluated the photoprotective potential of the marine-derived fungus Penicillium echinulatum, and found that certain compounds showed inhibitory effects on UVA-induced ROS generation while exhibiting phototoxic potential in 3T3 cells but not in the RHS model, indicating low acute photoirritation and high photosafety potential. Viridicatin was considered weakly photoreactive and viridicatol showed no photoreactivity, both compounds inhibited UVA-induced ROS generation in HaCaT cells. The results suggest that metabolites produced by P. echinulatum have photoprotective and antioxidant potential with predicted photosafety and non-cytotoxicity for topical use.

MARINE BIOTECHNOLOGY (2021)

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Review Chemistry, Medicinal

Marine-Derived Compounds with Anti-Alzheimer's Disease Activities

Salar Hafez Ghoran et al.

Summary: Alzheimer's disease is an irreversible and progressive brain disorder that affects memory and thinking skills, posing a big concern for society due to the increasing aging population. Neuroprotective compounds from marine organisms are being studied for their potential anti-Alzheimer's disease activities, with a focus on inhibiting key enzymes and pathways involved in the pathogenesis of the disease.

MARINE DRUGS (2021)

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Article Chemistry, Medicinal

Metabolites from Marine-Derived Fungi as Potential Antimicrobial Adjuvants

Fernando Duraes et al.

Summary: The study reveals that marine-derived fungal metabolites have the potential to reverse antimicrobial resistance and inspire the synthesis of new antimicrobial drugs.

MARINE DRUGS (2021)

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Review Biochemistry & Molecular Biology

Marine natural products

Anthony R. Carroll et al.

Summary: This review summarizes the literature on marine natural products (MNPs) published in 2019, covering a wide range of organisms and compounds, with a focus on new compounds and their biological activities and country of origin. Methods for studying marine fungi and their chemical diversity are also discussed.

NATURAL PRODUCT REPORTS (2021)

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Review Plant Sciences

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

David J. Newman et al.

JOURNAL OF NATURAL PRODUCTS (2020)

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Review Chemistry, Medicinal

Chemical Diversity and Biological Activities of Meroterpenoids from Marine Derived-Fungi: A Comprehensive Update

Amr El-Demerdash et al.

MARINE DRUGS (2020)

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Review Chemistry, Medicinal

A Review of Terpenes from Marine-Derived Fungi: 2015-2019

Minghua Jiang et al.

MARINE DRUGS (2020)

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Review Chemistry, Medicinal

Marine Terpenoids from Polar Latitudes and Their Potential Applications in Biotechnology

Laura Nunez-Pons et al.

MARINE DRUGS (2020)

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Article Biotechnology & Applied Microbiology

An aurora of natural products-based drug discovery is coming

Yaojun Tong et al.

SYNTHETIC AND SYSTEMS BIOTECHNOLOGY (2020)

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Article Chemistry, Multidisciplinary

Identification and bioactivity evaluation of secondary metabolites from Antarctic-derived Penicillium chrysogenum CCTCC M 2020019

Imran Khan et al.

RSC ADVANCES (2020)

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Article Ecology

Fungi from Admiralty Bay (King George Island, Antarctica) Soils and Marine Sediments

Lia Costa Pinto Wentzel et al.

MICROBIAL ECOLOGY (2019)

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Article Plant Sciences

Secondary Metabolites Produced by Combined Culture of Penicillium crustosum and a Xylaria sp.

Guihong Yu et al.

JOURNAL OF NATURAL PRODUCTS (2019)

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Review Infectious Diseases

Antitumor Potential of Seaweed Derived-Endophytic Fungi

Thaiz Rodrigues Teixeira et al.

ANTIBIOTICS-BASEL (2019)

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Article Plant Sciences

Furanone derivative and sesquiterpene from Antarctic marine-derived fungus Penicillium sp. S-1-18

Yue Zhou et al.

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2018)

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Review Ecology

Natural products from polar organisms: Structural diversity, bioactivities and potential pharmaceutical applications

Vikash Chandra Tripathi et al.

POLAR SCIENCE (2018)

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Article Biochemistry & Molecular Biology

Cadopherone and colomitide polyketides from Cadophora wood-rot fungi associated with historic expedition huts in Antarctica

Yudi Rusman et al.

PHYTOCHEMISTRY (2018)

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Review Chemistry, Medicinal

Secondary Metabolites from Polar Organisms

Yuan Tian et al.

MARINE DRUGS (2017)

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Article Multidisciplinary Sciences

A genome Tree of Life for the Fungi kingdom

JaeJin Choi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Article Microbiology

Global analysis of biosynthetic gene clusters reveals vast potential of secondary metabolite production in Penicillium species

Jens Christian Nielsen et al.

NATURE MICROBIOLOGY (2017)

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Review Plant Sciences

Natural Products as Sources of New Drugs from 1981 to 2014

David J. Newman et al.

JOURNAL OF NATURAL PRODUCTS (2016)

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Article Plant Sciences

3-Nitroasterric Acid Derivatives from an Antarctic Sponge-Derived Pseudogymnoascus sp Fungus

Luis Figueroa et al.

JOURNAL OF NATURAL PRODUCTS (2015)

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Article Biodiversity Conservation

Antibacterial, antifungal and antiprotozoal activities of fungal communities present in different substrates from Antarctica

Vivian N. Goncalves et al.

POLAR BIOLOGY (2015)

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Article Biotechnology & Applied Microbiology

Diversity of cultivable fungi associated with Antarctic marine sponges and screening for their antimicrobial, antitumoral and antioxidant potential

Marlene Henriquez et al.

WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY (2014)

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Article Chemistry, Organic

Biomimetic Total Synthesis of ent-Penilactone A and Penilactone B

Justin T. J. Spence et al.

ORGANIC LETTERS (2013)

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Article Plant Sciences

Cytotoxic Metabolites from the Antarctic Psychrophilic Fungus Oidiodendron truncatum

Liyuan Li et al.

JOURNAL OF NATURAL PRODUCTS (2012)

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Article Chemistry, Organic

Penilactones A and B, two novel polyketides from Antarctic deep-sea derived fungus Penicillium crustosum PRB-2

Guangwei Wu et al.

TETRAHEDRON (2012)

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Review Biochemistry & Molecular Biology

Secondary metabolites of fungi from marine habitats

Mostafa E. Rateb et al.

NATURAL PRODUCT REPORTS (2011)

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Article Chemistry, Multidisciplinary

NEW BUTYROLACTONE FROM A MARINE-DERIVED FUNGUS ASPERGILLUS SP

Aurelio San-Martin et al.

JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2011)

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Article Plant Sciences

Asperelines A-F, Peptaibols from the Marine-Derived Fungus Trichoderma asperellum

Jinwei Ren et al.

JOURNAL OF NATURAL PRODUCTS (2009)

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Review Biochemistry & Molecular Biology

Molecules derived from the extremes of life

Zoe E. Wilson et al.

NATURAL PRODUCT REPORTS (2009)

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Article Plant Sciences

Bioactive asterric acid derivatives from the Antarctic ascomycete fungus Geomyces sp.

Yan Li et al.

JOURNAL OF NATURAL PRODUCTS (2008)

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Article Multidisciplinary Sciences

Lessons from natural molecules

J Clardy et al.

NATURE (2004)

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Review Microbiology

Relationship between secondary metabolism and fungal development

AM Calvo et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2002)

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Natural Products from Chilean and Antarctic Marine Fungi and Their Biomedical Relevance

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