期刊
MARINE DRUGS
卷 21, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/md21010041
关键词
porphyrin; Isabela; hemin; X-ray diffraction; NOESY NMR; cytotoxic
Two new free porphyrins, isabellins A and B, along with known compounds corallistin D and deuteroporphyrin IX, were isolated from a marine sponge Isabela sp. The structures were determined using high-resolution mass spectrometry, UV-Vis spectroscopy, and extensive NOESY NMR spectroscopic experiments. Isabellin A exhibited potent cytotoxicity against the NS-1 murine myeloma cell line.
Two novel free porphyrins, isabellins A and B, as well as the known compounds corallistin D and deuteroporphyrin IX were isolated from a marine sponge Isabela sp. LC-MS analysis of the crude extract revealed that the natural products were present both as free porphyrins and iron(III) coordinated hemins, designated isabellihemin A, isabellihemin B, corallistihemin D and deuterohemin IX, respectively. Structures were determined via high-resolution mass spectrometry, UV-Vis spectroscopy and extensive NOESY NMR spectroscopic experiments. The type-I alkyl substitution pattern of isabellin A and isabellihemin A was assigned unambiguously by single crystal X-ray diffraction. Biological evaluation of the metabolites revealed potent cytotoxicity for isabellin A against the NS-1 murine myeloma cell line.
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