N-3 PUFA Deficiency Aggravates Streptozotocin-Induced Pancreatic Injury in Mice but Dietary Supplementation with DHA/EPA Protects the Pancreas via Suppressing Inflammation, Oxidative Stress and Apoptosis

Article Biochemistry & Molecular Biology

Grape seed proanthocyanidin extract suppresses oxidative stress in the rat pancreas of type-1 diabetes

Sanna Rajasekhar et al.

Summary: This study suggests that the combination of GSPE and INS can effectively reduce oxidative stress and pancreatic degeneration in T1DM rats, and improve the number of beta cells.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2023)

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Article Biochemistry & Molecular Biology

Mitigation of streptozotocin-induced alterations by natural agents via upregulation of PDX1 and Ins1 genes in male rats

Nagwa Ibrahim Shehata et al.

Summary: Diabetes is a globally prevalent endocrine disorder, and herbal medicine for diabetes mitigation has gained increasing interest. This study evaluated the effects of avocado and cinnamon extracts on gene expression in diabetic rats and found that these extracts improved blood glucose, insulin, lipid profile, and antioxidant capacity, and upregulated pancreatic gene expression. However, the effects of metformin, a standard drug, were more pronounced.

JOURNAL OF FOOD BIOCHEMISTRY (2022)

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Article Cell Biology

Punicalagin protects against the development of pancreatic injury and insulitis in rats with induced T1DM by reducing inflammation and oxidative stress

Haitham L. Abdulhadi et al.

Summary: Punicalagin has protective effects against pancreatic inflammation and oxidative damage in T1DM, reducing inflammatory and adhesion molecule levels, enhancing antioxidant capacity, and improving pancreatic histopathology and immune response in diabetic rats.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2022)

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Article Medicine, Research & Experimental

Syzygium jambos extract mitigates pancreatic oxidative stress, inflammation and apoptosis and modulates hepatic IRS-2/AKT/GLUT4 signaling pathway in streptozotocin-induced diabetic rats

Mona F. Mahmoud et al.

Summary: The study tested the protective effect of Syzygium jambos (SJ) bark extract against streptozotocin-induced diabetes in rats and found that the extract can reduce hyperglycemia by activating endogenous antioxidants, increasing insulin production, and suppressing inflammation and apoptosis. This therapeutic effect may be attributed to the presence of 10 secondary metabolites identified by LC-MS.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Medicine, Research & Experimental

Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid

Mariana Rodrigues Davanso et al.

Summary: The study found that macrophages in Type 1 diabetes patients are in an inflammatory state, and docosahexaenoic acid (DHA) can alleviate this inflammation.

CLINICAL SCIENCE (2021)

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Article Agriculture, Multidisciplinary

ι-Carrageenan Tetrasaccharide from ι-Carrageenan Inhibits Islet β Cell Apoptosis Via the Upregulation of GLP-1 to Inhibit the Mitochondrial Apoptosis Pathway

Yanqi Li et al.

Summary: Research suggests that iota CTs can alleviate insulin resistance caused by a high-fat and high-sucrose diet through multiple pathways, including reducing blood glucose levels, enhancing glucose tolerance, decreasing beta cell apoptosis, and promoting insulin secretion. Additionally, iota CTs increase GLP-1 levels by regulating bile acid levels, which contributes to the inhibition of beta cell apoptosis.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

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Article Endocrinology & Metabolism

Type 1 diabetes in 2017: global estimates of incident and prevalent cases in children and adults

Anders Green et al.

Summary: Global estimates for incident and prevalent cases of type 1 diabetes in 2017 were found to be 234,710 and 9,004,610 respectively, with high-income countries accounting for a significant portion. Asia had the largest number of cases, reflecting its population size. Sensitivity analyses showed estimates could deviate by up to 15%.

DIABETOLOGIA (2021)

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Article Biochemistry & Molecular Biology

Resolvin D1 Decreases Severity of Streptozotocin-Induced Type 1 Diabetes Mellitus by Enhancing BDNF Levels, Reducing Oxidative Stress, and Suppressing Inflammation

Siresha Bathina et al.

Summary: RVD1 can prevent STZ-induced type 1 diabetes by its anti-apoptotic, anti-inflammatory, and antioxidant actions and by activating the Pdx gene that is needed for pancreatic beta cell proliferation. The study results suggest that RVD1 can alleviate the severity of type 1 diabetes through multiple pathways.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Agriculture, Multidisciplinary

Dietary Supplementation with Exogenous Sea-Cucumber-Derived Ceramides and Glucosylceramides Alleviates Insulin Resistance in High-Fructose-Diet-Fed Rats by Upregulating the IRS/PI3K/Akt Signaling Pathway

Jin-Yue Yang et al.

Summary: The study found that sea-cucumber-derived glucosylceramides and ceramides have a certain improvement effect on insulin resistance, as they can improve glucose tolerance, reduce blood sugar levels, and alleviate accompanying hypertension. Glucosylceramides alleviate hepatic insulin resistance mainly by inhibiting gluconeogenesis and promoting glycogen synthesis, while ceramides alleviate insulin resistance mainly by promoting glycogen synthesis in skeletal muscle.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

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Article Nutrition & Dietetics

Dietary n-3 PUFA Deficiency Increases Vulnerability to Scopolamine-Induced Cognitive Impairment in Male C57BL/6 Mice

Dan-Dan Wang et al.

Summary: This study demonstrates that dietary n-3 PUFA deficiency decreases brain DHA concentrations and increases vulnerability to scopolamine-induced cognitive impairment in C57BL/6 male mice. Rats deficient in n-3 PUFA show poorer spatial learning and memory, more obvious cholinergic dysfunction, oxidative stress, apoptosis, neuroinflammation, and neurodevelopmental delay compared to their saline-treated controls.

JOURNAL OF NUTRITION (2021)

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Article Food Science & Technology

Dietary EPA-Enriched Phospholipids Alleviate Chronic Stress and LPS-Induced Depression- and Anxiety-Like Behavior by Regulating Immunity and Neuroinflammation

Cheng-Cheng Wang et al.

Summary: Comparative investigation showed that dietary EPA-PL had superior effects in alleviating depression- and anxiety-like behavior compared to EPA-EE. Further studies revealed that EPA-PL regulated immunity, monoamine systems, and the HPA axis through multi-target interactions, including inhibition of neuroinflammation and apoptosis.

MOLECULAR NUTRITION & FOOD RESEARCH (2021)

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Article Microbiology

Eicosapentaenoic and docosahexaenoic acids attenuate hyperglycemia through the microbiome-gut-organs axis in db/db mice

Pan Zhuang et al.

Summary: The study found that DHA and EPA can significantly alleviate hyperglycemia and insulin resistance by altering the gut microbiome and metabolites, thereby improving symptoms of diabetes, with EPA showing a more pronounced effect.

MICROBIOME (2021)

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Article Multidisciplinary Sciences

VEGF-B ablation in pancreatic β-cells upregulates insulin expression without affecting glucose homeostasis or islet lipid uptake

Frank Chenfei Ning et al.

SCIENTIFIC REPORTS (2020)

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Article Biochemistry & Molecular Biology

A high linoleic acid diet exacerbates metabolic responses and gut microbiota dysbiosis in obese rats with diabetes mellitus

Hsiu-Chuan Lee et al.

FOOD & FUNCTION (2019)

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Article Endocrinology & Metabolism

IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045

N. H. Cho et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2018)

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Article Agriculture, Multidisciplinary

Protective Effects of DHA-PC against Vancomycin-Induced Nephrotoxicity through the Inhibition of Oxidative Stress and Apoptosis in BALB/c Mice

Haohao Shi et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)

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Article Food Science & Technology

The Protective Activities of Dietary Sea Cucumber Cerebrosides against Atherosclerosis through Regulating Inflammation and Cholesterol Metabolism in Male Mice

Lingyu Zhang et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2018)

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Article Medicine, Research & Experimental

Protective effect of wax apple (Syzygium samarangense (Blume) Merr. & LM Perry) against streptozotocin-induced pancreatic ss-cell damage in diabetic rats

Aree Khamchan et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Biochemistry & Molecular Biology

Mechanism of Generation of Oxidative Stress and Pathophysiology of Type 2 Diabetes Mellitus: How Are They Interlinked?

Kanwal Rehman et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2017)

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Article Medicine, Research & Experimental

ω-3 polyunsaturated fatty acids ameliorate type 1 diabetes and autoimmunity

Xinyun Bi et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

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Article Immunology

Omega-3 polyunsaturated fatty acid supplementation attenuates microglial-induced inflammation by inhibiting the HMGB1/TLR4/NF-κB pathway following experimental traumatic brain injury

Xiangrong Chen et al.

JOURNAL OF NEUROINFLAMMATION (2017)

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Article Endocrinology & Metabolism

The global economic burden of diabetes in adults aged 20-79 years: a cost-of-illness study

Christian Bommer et al.

LANCET DIABETES & ENDOCRINOLOGY (2017)

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Article Pharmacology & Pharmacy

Nano-curcumin safely prevents streptozotocin-induced inflammation and apoptosis in pancreatic beta cells for effective management of Type 1 diabetes mellitus

Raghu Ganugula et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

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Article Medicine, Research & Experimental

Protective effect of aqueous seed extract of Vitis Vinifera against oxidative stress, inflammation and apoptosis in the pancreas of adult male rats with diabetes mellitus

Siti Hajar Adam et al.

BIOMEDICINE & PHARMACOTHERAPY (2016)

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Review Endocrinology & Metabolism

MST1: a promising therapeutic target to restore functional beta cell mass in diabetes

Amin Ardestani et al.

DIABETOLOGIA (2016)

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Review Endocrinology & Metabolism

Lipids and immunoinflammatory pathways of beta cell destruction

Yumi Imai et al.

DIABETOLOGIA (2016)

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Article Biochemistry & Molecular Biology

Healthy effect of different proportions of marine ω-3 PUFAs EPA and DHA supplementation in Wistar rats: Lipidomic biomarkers of oxidative stress and inflammation

Gabriel Dasilva et al.

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Article Food Science & Technology

n-3 Polyunsaturated fatty acids protect against pancreatic β-cell damage due to ER stress and prevent diabetes development

Jie Wang et al.

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Article Biochemistry & Molecular Biology

Fish oil ameliorates trimethylamine N-oxide-exacerbated glucose intolerance in high-fat diet-fed mice

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n-3 polyunsaturated fatty acids modulate metabolism of insulin-sensitive tissues: implication for the prevention of type 2 diabetes

Alexandre Pinel et al.

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Linoleic and alpha linolenic acids ameliorate streptozotocin-induced diabetes in mice

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Cytotoxic Mechanisms Employed by Mouse T Cells to Destroy Pancreatic β-Cells

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Berberine, an isoquinoline alkaloid, inhibits streptozotocin-induced apoptosis in mouse pancreatic islets through down-regulating Bax/Bcl-2 gene expression ratio

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High Pancreatic n-3 Fatty Acids Prevent STZ-Induced Diabetes in Fat-1 Mice: Inflammatory Pathway Inhibition

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Cellular Production of n-3 PUFAs and Reduction of n-6-to-n-3 Ratios in the Pancreatic β-Cells and Islets Enhance Insulin Secretion and Confer Protection Against Cytokine-Induced Cell Death

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N-3 PUFA Deficiency Aggravates Streptozotocin-Induced Pancreatic Injury in Mice but Dietary Supplementation with DHA/EPA Protects the Pancreas via Suppressing Inflammation, Oxidative Stress and Apoptosis

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