期刊
MARINE DRUGS
卷 20, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/md20120743
关键词
ocean acidification (OA); Ulva prolifera; metabolomics; lipidomics; LC-MS; NMR; macroalgae
资金
- Acid.it (Progetto Premiale) grant by Italian Ministry of University and Research (MUR)
- Deutsche Forschungsgemeinschaft (DFG) [EL 179/13-1]
- OGS
This study investigated the metabolic profiles of the macroalga Ulva prolifera under acidified and normal conditions using a multi-omics approach. The results showed that U. prolifera grows faster in acidified environments, with metabolic pathways being modulated and lipid biosynthesis being remodeled. These findings have implications for both the marine ecosystem and potential nutraceutical applications.
Ocean acidification (OA) is a dramatic perturbation of seawater environments due to increasing anthropogenic emissions of CO2. Several studies indicated that OA frequently induces marine biota stress and a reduction of biodiversity. Here, we adopted the macroalga Ulva prolifera as a model and applied a complementary multi-omics approach to investigate the metabolic profiles under normal and acidified conditions. Our results show that U. prolifera grows at higher rates in acidified environments. Consistently, we observed lower sucrose and phosphocreatine concentrations in response to a higher demand of energy for growth and a higher availability of essential amino acids, likely related to increased protein biosynthesis. In addition, pathways leading to signaling and deterrent compounds appeared perturbed. Finally, a remarkable shift was observed here for the first time in the fatty acid composition of triglycerides, with a decrease in the relative abundance of PUFAs towards an appreciable increase of palmitic acid, thus suggesting a remodeling in lipid biosynthesis. Overall, our studies revealed modulation of several biosynthetic pathways under OA conditions in which, besides the possible effects on the marine ecosystem, the metabolic changes of the alga should be taken into account considering its potential nutraceutical applications.
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